Leukocyte-Endothelial Cell Interactions in the Inflammatory Response

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Chemokines

2000 • 3,773 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Leukocyte-endothelial adhesion molecules

1994 • 1,884 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

1990 • 948 citations

Mechanisms That Regulate the Function of the Selectins and Their Ligands

1999 • 931 citations

Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo

1999 • 904 citations

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ

1993 • 896 citations

Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking

1998 • 832 citations

THE ROLE OF ENDOTHELIAL CELLS IN INFLAMMATION

1990 • 808 citations

Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

1997 • 731 citations

Chemokines in pathology and medicine

2001 • 653 citations

The biology of cell locomotion within three-dimensional extracellular matrix

2000 • 647 citations

Chemokines in tissue-specific and microenvironment-specific lymphocyte homing

2000 • 643 citations

JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes

2002 • 636 citations

Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.

1988 • 626 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

Human junction adhesion molecule regulates tight junction resealing in epithelia

2000 • 521 citations

RhoA is required for monocyte tail retraction during transendothelial migration

2001 • 498 citations

CD99 plays a major role in the migration of monocytes through endothelial junctions

2002 • 497 citations

Endothelial cell‐to‐cell junctions

1995 • 481 citations

Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo

1993 • 468 citations

A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding

1995 • 435 citations

Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions

1999 • 430 citations

Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

1998 • 415 citations

Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines

2001 • 398 citations

Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion.

1990 • 391 citations

ELECTRON MICROGRAPHIC OBSERVATIONS ON THE EMIGRATION OF LEUCOCYTES

1960 • 388 citations

PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus

1995 • 383 citations

A central role for microvillous receptor presentation in leukocyte adhesion under flow

1995 • 380 citations

A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions.

1989 • 365 citations

Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability

2001 • 340 citations

Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells.

1993 • 340 citations

Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.

1996 • 334 citations

VE-cadherin antibody accelerates neutrophil recruitment in vivo

1997 • 314 citations

Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.

1994 • 296 citations

Leukocyte Recruitment in the Cerebrospinal Fluid of Mice with Experimental Meningitis Is Inhibited by an Antibody to Junctional Adhesion Molecule (Jam)

1999 • 288 citations

Real-Time Imaging of Vascular Endothelial-Cadherin During Leukocyte Transmigration Across Endothelium

2001 • 287 citations

Neutrophil transendothelial migration is independent of tight junctions and occurs preferentially at tricellular corners.

1997 • 280 citations

Interleukin 4 or oncostatin M induces a prolonged increase in P-selectin mRNA and protein in human endothelial cells.

1996 • 248 citations

Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.

1995 • 240 citations

Histamine induces leukocyte rolling in post-capillary venules. A P-selectin-mediated event.

1994 • 239 citations

Endothelial Cell E- and P-Selectin and Vascular Cell Adhesion Molecule-1 Function as Signaling Receptors

1998 • 230 citations

L-selectin (CD62L) cross-linking signals neutrophil adhesive functions via the Mac-1 (CD11b/CD18) beta 2-integrin.

1995 • 228 citations

Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1.

1995 • 210 citations

Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism

1994 • 204 citations

An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane.

1996 • 198 citations

Monocytes Induce Reversible Focal Changes in Vascular Endothelial Cadherin Complex during Transendothelial Migration under Flow

2000 • 195 citations

Analysis of tight junctions during neutrophil transendothelial migration

2000 • 191 citations

THE SITE OF LEUCOCYTE EMIGRATION DURING INFLAMMATION

1961 • 190 citations

Soluble Domain 1 of Platelet–Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo

1997 • 184 citations

Endothelial-dependent Mechanisms Regulate Leukocyte Transmigration: A Process Involving the Proteasome and Disruption of the Vascular Endothelial–Cadherin Complex at Endothelial Cell-to-Cell Junctions

1997 • 182 citations

The Use of Lymphocyte Function–Associated Antigen (Lfa)-1–Deficient Mice to Determine the Role of Lfa-1, Mac-1, and α4 Integrin in the Inflammatory Response of Neutrophils

2001 • 180 citations

The native structure of intercellular adhesion molecule-1 (ICAM-1) is a dimer. Correlation with binding to LFA-1.

1995 • 177 citations

Of Man and Mouse: Leukocyte and Endothelial Adhesion Molecule Deficiencies

1999 • 159 citations

Cytokine-Activated Endothelial Cells Delay Neutrophil Apoptosis in Vitro and in Vivo

1999 • 157 citations

Thrombin induces endothelial type II activation in vitro: IL-1 and TNF-alpha-independent IL-8 secretion and E-selectin expression.

1997 • 152 citations

CD99 (MIC2) regulates the LFA-1/ICAM-1-mediated adhesion of lymphocytes, and its gene encodes both positive and negative regulators of cellular adhesion.

1997 • 151 citations

Apoptosis of immature thymocytes mediated by E2/CD99.

1997 • 149 citations

β1 Integrins Are Critically Involved in Neutrophil Locomotion in Extravascular Tissue In Vivo

1998 • 147 citations

Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation.

1996 • 141 citations

Effects of human neutrophil chemotaxis across human endothelial cell monolayers on the permeability of these monolayers to ions and macromolecules

1988 • 135 citations

Monocyte-selective transendothelial migration: dissection of the binding and transmigration phases by an in vitro assay.

1992 • 133 citations

Endothelial Myosin Light Chain Kinase Regulates Neutrophil Migration Across Human Umbilical Vein Endothelial Cell Monolayer

1998 • 131 citations

Dynamic imaging of neutrophil migration in three dimensions: mechanical interactions between cells and matrix

1997 • 124 citations

Blockade of platelet endothelial cell adhesion molecule-1 protects against myocardial ischemia and reperfusion injury in cats.

1996 • 110 citations

Integrin αMβ2-Mediated Cell Migration to Fibrinogen and Its Recognition Peptides

2001 • 108 citations

Neutrophil platelet endothelial cell adhesion molecule-1 participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation.

1997 • 103 citations

In Vitro Degradation of Endothelial Catenins by a Neutrophil Protease

1998 • 102 citations

Shear-dependent Eosinophil Transmigration on Interleukin 4–stimulated Endothelial Cells

2001 • 98 citations

The E2 molecule (CD99) specifically triggers homotypic aggregation of CD4+ CD8+ thymocytes.

1995 • 97 citations

Signaling via β2 Integrins Triggers Neutrophil-Dependent Alteration in Endothelial Barrier Function

2000 • 95 citations

Antibody to Platelet/Endothelial Cell Adhesion Molecule-1 Reduces Myocardial Infarct Size in a Rat Model of Ischemia-Reperfusion Injury

1996 • 90 citations

Antibodies to the Junctional Adhesion Molecule Cause Disruption of Endothelial Cells and Do Not Prevent Leukocyte Influx into the Meninges after Viral or Bacterial Infection

2000 • 90 citations

Migration of Leukocytes across Endothelial Junctions: Some Concepts and Controversies

2001 • 86 citations

CD99 Engagement on Human Peripheral Blood T Cells Results in TCR/CD3-Dependent Cellular Activation and Allows for Th1-Restricted Cytokine Production

1998 • 74 citations

Tumor Necrosis Factor-α- or Lipopolysaccharide-induced Expression of the Murine P-selectin Gene in Endothelial Cells Involves Novel κB Sites and a Variant Activating Transcription Factor/cAMP Response Element

1998 • 73 citations

Shear Stress Affects Migration Behavior of Polymorphonuclear Cells Arrested on Endothelium

2000 • 71 citations

Engagement of CD99 Induces Up-Regulation of TCR and MHC Class I and II Molecules on the Surface of Human Thymocytes

1998 • 71 citations

CD99 (E2) up-regulates α 4β 1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions

2000 • 69 citations

Preferential sites for stationary adhesion of neutrophils to cytokine-stimulated HUVEC under flow conditions

2000 • 67 citations

A Role for CD99 in T Cell Activation

1999 • 60 citations

Endothelial [Ca2+]i signaling during transmigration of polymorphonuclear leukocytes

2000 • 57 citations

Transgenic Mice Expressing Different Levels of Soluble Platelet/Endothelial Cell Adhesion Molecule-IgG Display Distinct Inflammatory Phenotypes

1999 • 43 citations

Cell Surface Glycosaminoglycans Do Not Serve as Ligands for PECAM-1

1998 • 31 citations

Vascular function in hemostasis

2006 • 16 citations

Leukocyte-endothelial cell adhesion molecules in transendothelial migration.

1999 • 15 citations

Relationship between Tight Junctions and Leukocyte Transmigration

2001 • 13 citations

CD57 Workshop Panel Report

1997 • 13 citations

Transendothelial migration and interstitial migration of monocytes are mediated by separate domains of monocyte CD31

1997 • 7 citations

Vascular Function in Hemostasis

2019 • 5 citations