CD59 cross-linking induces secretion of APO2 ligand in overactivated human T cells

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

1988 • 3,038 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

LAT Palmitoylation

1998 • 837 citations

Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

1996 • 653 citations

CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.

1989 • 640 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

Natural Killer (NK) Cell–mediated Cytotoxicity: Differential Use of TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells

1998 • 517 citations

Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

1999 • 477 citations

Monocyte-mediated Tumoricidal Activity via the Tumor Necrosis Factor–related Cytokine, TRAIL

1999 • 470 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Apoptosis in Fas Ligand-Resistant Melanoma Cells and Mediates CD4 T Cell Killing of Target Cells

1998 • 316 citations

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

1985 • 299 citations

TRAIL/Apo-2-ligand-induced apoptosis in human T cells

1998 • 273 citations

Polyunsaturated Fatty Acids Inhibit T Cell Signal Transduction by Modification of Detergent-insoluble Membrane Domains

1998 • 254 citations

Activation-induced death of mature T cells in the regulation of immune responses

1995 • 248 citations

Involvement of APO2 ligand/TRAIL in activation-induced death of Jurkat and human peripheral blood T cells

1998 • 188 citations

Identification of a ligand for the death-domain-containing receptor Apo3

1998 • 186 citations

Overlapping but Nonidentical Binding Sites on CD2 for CD58 and a Second Ligand CD59

1992 • 165 citations

Fas‐based lymphocyte‐mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway?

1994 • 157 citations

CD59 functions as a signal-transducing molecule for human T cell activation.

1991 • 153 citations

Cross‐linking of the CAMPATH‐1 antigen (CD52) mediates growth inhibition in human B‐ and T‐lymphoma cell lines, and subsequent emergence of CD52‐deficient cells

1998 • 141 citations

Thymocytes in Thy-1−/− mice show augmented TCR signaling and impaired differentiation

1997 • 123 citations

A conformational epitope expressed upon association of CD3-epsilon with either CD3-delta or CD3-gamma is the main target for recognition by anti-CD3 monoclonal antibodies.

1991 • 97 citations

Release of preformed Fas ligand in soluble form is the major factor for activation‐induced death of Jurkat T cells

1996 • 94 citations

CPP32 inhibition prevents Fas‐induced ceramide generation and apoptosis in human cells

1996 • 82 citations

Thy-1 triggers mouse thymocyte apoptosis through a bcl-2-resistant mechanism.

1994 • 72 citations

The glycosylphosphatidylinositol‐anchored CD59 protein stimulates both T cell receptor ζ/ZAP‐70‐dependent and ‐independent signaling pathways in T cells

1995 • 72 citations

Antibody Cross-linking of the Glycosylphosphatidylinositol-linked Protein CD59 on Hematopoietic Cells Induces Signaling Pathways Resembling Activation by Complement

1998 • 60 citations

CD2-induced apoptosis in activated human peripheral T cells: a Fas-independent pathway that requires early protein tyrosine phosphorylation.

1996 • 58 citations

Resistance to apoptosis correlates with a highly proliferative phenotype and loss of Fas and CPP32 (caspase-3) expression in human leukemia cells

1998 • 53 citations

Requirement of P56lck in T-Cell Receptor CD3-Mediated Apoptosis and Fas-Ligand Induction Jurkat Cells

1995 • 49 citations

CD48 is a low affinity ligand for human CD2.

1993 • 42 citations

Increased intracellular cyclic AMP inhibits inositol phospholipid hydrolysis induced by perturbation of the T cell receptor/CD3 complex but not by G-protein stimulation. Association with protein kinase A-mediated phosphorylation of phospholipase C-γ 1

1992 • 42 citations

Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1.

1995 • 36 citations

Activation-induced NK cell death triggered by CD2 stimulation

1998 • 33 citations