Maturation of the humoral immune response as an optimization problem

Discounted Dynamic Programming

1965 • 963 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1984 • 534 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

Evolutionary and Somatic Selection of the Antibody Repertoire in the Mouse

1987 • 388 citations

Molecular events during maturation of the immune response to oxazolone

1985 • 380 citations

The Dynamic Nature of the Antibody Repertoire

1988 • 321 citations

The Role of Somatic Hypermutation in the Generation of Antibody Diversity

1989 • 305 citations

Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development

1987 • 218 citations

A Model for the Adjustment of the Mitotic Clock by Cyclin and MPF Levels

1991 • 105 citations

The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?

1990 • 54 citations

Growth and Selection of B Cells In Vivo

1989 • 10 citations