Accessory Cells and T Cell Activation. The Relationship Between Two Components of Macrophage Accessory Cell Function: I-A and IL1

IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE

1967 • 2,062 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

The functional relationship of the interleukins.

1980 • 660 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

Separation of mouse spleen cells by passage through columns of sephadex G-10

1974 • 650 citations

FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES

1973 • 611 citations

Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

1982 • 576 citations

Regulation of murine macrophage Ia antigen expression by a lymphokine with immune interferon activity.

1982 • 481 citations

Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing.

1983 • 447 citations

Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility ( H-2 ) Type

1969 • 425 citations

Two distinct factors are required for induction of T-cell growth

1980 • 416 citations

Lymphocyte specificity to protein antigens. I. Characterization of the antigen-induced in vitro T cell-dependent proliferative response with lymph node cells from primed mice.

1977 • 361 citations

H-2 Dependence of Co-Operation Between T and B Cells in Vivo

1972 • 285 citations

STUDIES ON ARTIFICIAL ANTIGENS

1963 • 219 citations

T-Cell lymphoma model for the analysis of interleukin 1-mediated T-cell activation.

1981 • 205 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

Orientation of cell-surface antigens in the lipid bilayer of lymphocyte plasma membrane

1977 • 175 citations

Lymphocyte Specificity to Protein Antigens

1977 • 175 citations

Relationship between production and release of lymphocyte-activating factor (interleukin 1) by murine macrophages

1981 • 174 citations

Self recognition in allogeneic radiation bone marrow chimeras. A radiation- resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells

1981 • 164 citations

Fever and immunoregulation. III. Hyperthermia augments the primary in vitro humoral immune response.

1983 • 151 citations

Effect of IFN-γ on the immune response in vivo and on gene expression in vitro

1984 • 149 citations

Potentiation of Cultured Mouse Thymocyte Responses by Factors Released by Peripheral Leucocytes

1971 • 124 citations

The pyrogenic and mitogenic actions of interleukin-1 are related

1983 • 116 citations

Interferons as macrophage‐activating factors. II. Enhanced secretion of interleukin 1 by lipopolysaccharide‐stimulated human monocytes

1983 • 112 citations

Cellular origins of co-stimulator (IL2) and its activity in cytotoxic T lymphocyte responses.

1980 • 106 citations

The Ia molecule of the antigen-presenting cell plays a critical role in immune response gene regulation of T cell activation.

1983 • 105 citations

Monoclonal antibodies against HLA-DR antigens replace T helper cells in activation of B lymphocytes.

1983 • 82 citations

A Cellular Basis for Genetically Controlled Immunologic Unresponsiveness in Mice: Tolerance Induction in T-Cells

1973 • 82 citations

Secretion of mediators following T lymphocyte-macrophage interaction is regulated by the major histocompatibility complex.

1977 • 79 citations

Effects of anti-Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS, by specific anti-Ia sera.

1975 • 75 citations

Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells.

1983 • 74 citations

Both chains of HLA-DR bind to the membrane with a penultimate hydrophobic region and the heavy chain is phosphorylated at its hydrophilic carboxyl terminus.

1979 • 69 citations

Monoclonal antibodies to guinea pig Ia antigens. II. Effect on alloantigen-, antigen-, and mitogen-induced T lymphocyte proliferation in vitro.

1980 • 61 citations

Antigen presentation in the murine T lymphocyte proliferative response. II. Ir‐GAT‐controlled T lymphocyte responses require antigen‐presenting cells from a high responder donor

1978 • 55 citations

MHC‐Restricted T Cell Activation: Analysis with T Cell Hybridomas

1983 • 53 citations

Absence of Ir gene control of T cells recognizing foreign antigen in the context of allogeneic MHC molecules

1982 • 51 citations

Production of human immune interferon (Hu IFN‐γ) studied at the single cell level. Origin, evidence for spontaneous secretion and effect of cyclosporin A

1983 • 49 citations

Effects of Anti-Ia Serum on Mitogenic Responses

1975 • 43 citations

Inhibition of interleukin synthesis and T cell proliferation by a monoclonal anti-Ia antibody.

1983 • 42 citations

Interleukin 1 can replace the requirement for I-A-positive cells in the proliferation of antigen-primed T cells.

1982 • 40 citations

Chemical characteristics of Ia antigens

1978 • 33 citations

H-2-linked Ir gene control of T cell proliferative responses to the synthetic terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). I. Requirements for T cell activation in responder and nonresponder mice.

1980 • 27 citations

Neonatal suppression with anti-Ia antibody. I. Suppression of murine B lymphocyte development.

1982 • 23 citations

Glycosyltransferases and T-cell recognition

1981 • 17 citations

Binding of Bacterial Lipopolysaccharide to Histocompatibility-2-CompIex Proteins of Mouse Lymphocytes

1979 • 15 citations

Role of Ia-positive cells in the production of T cell-replacing factors: blocking of factor production with anti-Ia serum.

1980 • 14 citations

Effect of Anti‐Ia Serum In Vitro on Lipopolysaccharide‐Induced Proliferative Responses of Murine Bone Marrow and Spleen Cells

1982 • 3 citations

H-2-linked ir gene control of t cell proliferative responses to the synthetic terpolymer l-glutamic acid60-l-alanine30-l- -tyrosine10 (gat).

1980 • 2 citations