Tachykinin NK2 receptor antagonists for the treatment of irritable bowel syndrome

AGA technical review on irritable bowel syndrome

2002 • 1,391 citations

Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome

2000 • 1,139 citations

Types of neurons in the enteric nervous system

2000 • 803 citations

Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat

1988 • 655 citations

The mammalian tachykinin receptors

1995 • 496 citations

Neurochemical classification of myenteric neurons in the guinea-pig ileum

1996 • 484 citations

Neuromedin K: A novel mammalian tachykinin identified in porcine spinal cord

1983 • 432 citations

Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome

2003 • 414 citations

5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine

1998 • 353 citations

Irritable bowel syndrome: a little understood organic bowel disease?

2002 • 308 citations

Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome

2001 • 289 citations

A role for inflammation in irritable bowel syndrome?

2002 • 267 citations

[Irritable bowel syndrome].

1955 • 239 citations

IV. Modulation of intestinal inflammation by stress: basic mechanisms and clinical relevance

2001 • 222 citations

Irritable Bowel Syndrome

2003 • 208 citations

Characterization of Antisera Specific to NK1, NK2, and NK3 Neurokinin Receptors and their Utilization to Localize Receptors in the Rat Gastrointestinal Tract

1996 • 203 citations

Alterations of brain activity associated with resolution of emotional distress and pain in a case of severe irritable bowel syndrome

2003 • 174 citations

I. Receptors on visceral afferents

2001 • 172 citations

The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection

2001 • 162 citations

Substance P (Neurokinin-1) and Neurokinin A (Neurokinin-2) Receptor Gene and Protein Expression in the Healthy and Inflamed Human Intestine

2000 • 154 citations

Tachykinin receptors in the gut: physiological and pathological implications

2001 • 139 citations

Antibody-mediated gastrointestinal dysmotility in scleroderma

2002 • 133 citations

Pharmacology of transmission to gastrointestinal muscle

2002 • 102 citations

Role of tachykinins in castor oil diarrhoea in rats

1997 • 98 citations

Abnormal Motility in Patients With Ulcerative Colitis

2002 • 96 citations

Otilonium bromide in irritable bowel syndrome: a double‐blind, placebo‐controlled, 15‐week study

1998 • 95 citations

MEN 11420 (Nepadutant), a novel glycosylated bicyclic peptide tachykinin NK₂ receptor antagonist

1998 • 94 citations

The activation of bladder wall afferent nerves

1999 • 94 citations

Expression of substance P/neurokinin A-encoding preprotachykinin messenger ribonucleic acids in the rat enteric nervous system

1989 • 91 citations

Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats

1994 • 89 citations

Newly discovered tachykinins raise new questions about their peripheral roles and the tachykinin nomenclature

2003 • 88 citations

Serotonergic modulation of visceral sensation: upper gastrointestinal tract

2002 • 83 citations

Principles of tachykininergic co-transmission in the peripheral and enteric nervous system

2000 • 79 citations

Distribution of neurokinin-2 receptors in the guinea-pig gastrointestinal tract

1996 • 78 citations

A novel tachykinin NK2 receptor antagonist prevents motility‐stimulating effects of neurokinin A in small intestine

2001 • 75 citations

Tachykinin NK1 and NK2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro

1998 • 75 citations

Peripheral actions of tachykinins

2000 • 72 citations

Effects of nematode infection on sensitivity to intestinal distension: Role of tachykinin NK2 receptors

1997 • 68 citations

Neural mechanisms underlying migrating motor complex formation in mouse isolated colon

2001 • 67 citations

Role of tachykinin NK2 receptors in normal and altered rectal sensitivity in rats

2000 • 64 citations

Combinations of neurokinin receptor antagonists reduce visceral hyperalgesia.

2001 • 62 citations

Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon

2004 • 60 citations

Comparative effects of nonpeptide tachykinin receptor antagonists on experimental gut inflammation in rats and guinea-pigs

1998 • 57 citations

Interleukins 1 beta and 6 induce functional alteration of rat colonic motility: an in vitro study

2003 • 55 citations

Synergistic role of muscarinic acetylcholine and tachykinin NK-2 receptors in intestinal peristalsis

1994 • 54 citations

Tachykinin-dependent and -independent components of peristalsis in the guinea pig isolated distal colon

2001 • 53 citations

NK1, NK2 and NK3 tachykinin receptor localization and tachykinin distribution in the ileum of the mouse

2000 • 52 citations

Tachykininergic mediation of viscerosensitive responses to acute inflammation in rats: role of CGRP

1997 • 52 citations

Protein Kinase C Is Involved in Neurokinin Receptor Modulation of N- and L-Type Ca²⁺ Channels in DRG Neurons of the Adult Rat

2003 • 51 citations

Gq-linked NK2 receptors mediate neurally induced contraction of human sigmoid circular smooth muscle

2000 • 51 citations

Substance P Expression Correlates with Severity of Diarrhea in Cryptosporidiosis

2003 • 50 citations

Immunohistochemical demonstration of the NK1 tachykinin receptor on muscle and epithelia in guinea pig intestine

2001 • 49 citations

Stimulation and inhibition of gastrointestinal propulsion induced by substance P and substance K in the rat

1985 • 48 citations

Tachykinins and reflexly evoked atropine-resistant motility in the guinea pig colon in vivo.

1993 • 48 citations

In vitro characterization of tachykinin NK₂‐receptors modulating motor responses of human colonic muscle strips

1998 • 48 citations

Roles of Substance P Receptors in Human Colon Circular Muscle: Alterations in Diverticular Disease

2002 • 47 citations

Responses of rat spinal neurons to distension of inflamed colon: role of tachykinin NK2 receptors

2001 • 47 citations

Different tachykinin receptors mediate chloride secretion in the distal colon through activation of submucosal neurones

1999 • 47 citations

Contractile Responses to Natural Tachykinins and Selective Tachykinin Analogs in Normal and Inflamed Ileal and Colonic Muscle

2001 • 47 citations

Specialization of tachykinin NK1 and NK2 receptors in producing fast and slow atropine-resistant neurotransmission to the circular muscle of the guinea-pig colon

1994 • 45 citations

Occurrence, release, and effects of multiple tachykinins in cat colonic tissues and nerves

1991 • 45 citations

Antigen Inhalation Unmasks NK-2 Tachykinin Receptor–mediated Responses in Vagal Afferents

2000 • 44 citations

Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum

2000 • 44 citations

Alterations of neurokinin receptors and interstitial cells of Cajal during and after jejunal inflammation induced by Nippostrongylus brasiliensis in the rat

2002 • 44 citations

Effect of nepadutant at tachykinin NK2 receptors in human intestine and urinary bladder

2000 • 40 citations

Involvement of Tachykinins in Intestinal Inflammation

2001 • 39 citations

Role of nitric oxide-dependent and -independent mechanisms in peristalsis and accommodation in the rabbit distal colon.

1994 • 38 citations

Effects of tachykinin receptor antagonists on the rat jejunal distension pain response

1998 • 38 citations

Direct and indirect mechanosensory pathways from the colon to the inferior mesenteric ganglion

1993 • 38 citations

Implication of NK1 and NK2 receptors in rat colonic hypersecretion induced by interleukin 1β: Role of nitric oxide

1995 • 38 citations

Substance P‐induced vasodilatation is mediated by the neurokinin type 1 receptor but does not contribute to basal vascular tone in man

1999 • 38 citations

Role of tachykinin NK1, NK2 and NK3 receptors in the modulation of visceral hypersensitivity in the rat

2003 • 38 citations

Idiopathic chronic constipation: tachykinins as cotransmitters in colonic contraction

2001 • 37 citations

Differential alterations in tachykinin NK2 receptors in isolated colonic circular smooth muscle in inflammatory bowel disease and idiopathic chronic constipation

2001 • 36 citations

Cholinergic transmission to colonic circular muscle of children with slow‐transit constipation is unimpaired, but transmission via NK₂ receptors is lacking

2003 • 35 citations

PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors

2003 • 34 citations

SR 48968 selectively prevents faecal excretion following activation of tachykinin NK2 receptors in rats

1994 • 33 citations

Fourth Isoform of Preprotachykinin Messenger RNA Encoding for Substance P in the Rat Intestine

1994 • 31 citations

Involvement of stretch-sensitive calcium flux in mechanical transduction in visceral afferents

1999 • 30 citations

Antimuscarinic, calcium channel blocker and tachykinin NK2 receptor antagonist actions of otilonium bromide in the circular muscle of guinea-pig colon

1999 • 30 citations

Different Ca2+ influx pathways mediate tachykinin receptor-induced contraction in circular muscle of guinea-pig colon

1994 • 30 citations

Contribution of NK₂ tachykinin receptors to propulsion in the rabbit distal colon

2000 • 29 citations

Intrinsic nerve circuits of the gastrointestinal tract: identification of drug targets

2002 • 29 citations

Neural pathways and pharmacological modulation of defecation reflex in rats

1988 • 28 citations

MEN 11420, a potent and selective tachykinin NK2 receptor antagonist in the guinea-pig and human colon

1997 • 28 citations

Dual and selective antagonism of neurokinin NK1 and NK2 receptor-mediated responses in human colon mucosa

2003 • 27 citations

Neuronal tachykinin NK2 receptors mediate release of non-adrenergic non-cholinergic inhibitory transmitters in the circular muscle of guinea-pig colon

1995 • 27 citations

Interaction between neurokinin A, VIP, prostanoids, and enteric nerves in regulation of duodenal function

1998 • 27 citations

Cultured rat sensory neurones express functional tachykinin receptor subtypes 1, 2 and 3

1998 • 27 citations

Pharmacological characterisation of neurokinin receptors mediating anion secretion in rat descending colon mucosa

1993 • 26 citations

Tachykinins increase vascular permeability in the gastrointestinal tract of the rat

1996 • 26 citations

Involvement of tachykinin NK₂ receptors in the modulation of spontaneous motility in rat proximal colon

2000 • 25 citations

Sequential activation of the triple excitatory transmission to the circular muscle of guinea-pig colon

1997 • 25 citations

Neurokinins induce a relaxation of the rat duodenum "in vivo" by activating postganglionic sympathetic elements in prevertebral ganglia: involvement of an NK-2 type of neurokinin receptor.

1988 • 24 citations

Intrarectal injection of glycerol induces hypersensitivity to rectal distension in healthy subjects without modifying rectal compliance

2001 • 23 citations

5-HT₃receptors mediate inflammation-induced unmasking of functional tachykinin responses in vitro

2002 • 23 citations

Rectal distention-induced colonic net water secretion in rats involves tachykinins, capsaicin sensory, and vagus nerves

1997 • 22 citations

Tachykinin NK₂ receptors and enhancement of cholinergic transmission in the inflamed rat colon: an in vivo motility study

2001 • 22 citations

Effect of Nepadutant, a Neurokinin 2 Tachykinin Receptor Antagonist, on Immediate-Early Gene Expression after Trinitrobenzenesulfonic Acid-Induced Colitis in the Rat

2003 • 22 citations

Substance P modulates localized calcium transients and membrane current responses in murine colonic myocytes

2003 • 22 citations

Calcitonin gene‐related peptide facilitates serotonin release from guinea‐pig colonic mucosa via myenteric neurons and tachykinin NK₂/NK₃ receptors

2004 • 21 citations

Tachykinin receptors mediate atropine-resistant rat duodenal reflex contractions in vivo

1996 • 21 citations

Spasmolytic Effect of the NK2-Receptor-Selective Antagonist MEN 10,627 in Rat Small Intestine.

1994 • 21 citations

Control by tachykinin NK2 receptors of CRF1 receptor-mediated activation of hippocampal acetylcholine release in the rat and guinea-pig

2003 • 20 citations

The role of tachykinin NK₁ and NK₂ receptors in atropine‐resistant colonic propulsion in anaesthetized guinea‐pigs

1998 • 20 citations

Calcium waves in colonic myocytes produced by mechanical and receptor-mediated stimulation

1999 • 19 citations

Intestinal motor stimulation by the 5‐HT₄ receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon

2001 • 19 citations

Role of NK2 receptors in gastric barosensitivity and in experimental ileus in rats

2001 • 18 citations

Neurokinin A increases duodenal mucosal permeability, bicarbonate secretion, and fluid output in the rat

1997 • 18 citations

Nepadutant pharmacokinetics and dose-effect relationships as tachykinin NK2 receptor antagonist are altered by intestinal inflammation in rodent models.

2001 • 17 citations

Co-distribution of NK2 tachykinin receptors and Substance P in nerve endings of guinea-pig ileum

2000 • 17 citations

Protective effect of the tachykinin NK2receptor antagonist nepadutant in acute rectocolitis induced by diluted acetic acid in guinea-pigs

2000 • 16 citations

Excitatory motor innervation in the canine rectoanal region: Role of changing receptor populations

2002 • 16 citations

Rat gastrointestinal motor responses mediated via activation of neurokinin receptors

1999 • 15 citations

Tachykinin NK2 receptors facilitate acetylcholine release from guinea-pig isolated trachea

2000 • 15 citations

Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation

2001 • 15 citations

Tachykinin receptor antagonists in irritable bowel syndrome.

2002 • 15 citations

Chemical signaling from colonic smooth muscle cells to DRG neurons in culture

1999 • 14 citations

Evidence that tachykinin NK₂ receptors modulate resting tone in the rat isolated small intestine

1996 • 14 citations

Increased intestinal non‐substance P tachykinin concentrations in malignant midgut carcinoid disease

1999 • 14 citations

Multiple Neurokinin Receptor Subtypes Are Present in the Colon of the Cat and Rat

1991 • 13 citations

Characterization of tachykinin NK2 receptor on dog proximal colon. Antagonism by MEN 10,627 and SR 48,968

1996 • 13 citations

Inhibition of cholinergic neurotransmission in isolated guinea-pig main bronchi by SR 48968

1993 • 12 citations

Tachykinin NK2 receptor mediates contraction and ion transport in rat colon by different mechanisms

2001 • 12 citations

Effects of neurokinins on human colonic motility

1994 • 12 citations

Differential distribution of substance P binding sites in guinea-pig sympathetic ganglia

1998 • 11 citations

Modulation by opioid peptides of mechanosensory pathways supplying the guinea‐pig inferior mesenteric ganglion.

1996 • 10 citations

Pathophysiology in irritable bowel syndrome

2001 • 10 citations

Role of Peripheral Tachykinin Receptors in Neurogenic Inflammation of the Respiratory, Genitourinary and Gastrointestinal Systems

2003 • 8 citations

NK1 receptors mediated release of 6-keto-PGF1 alpha from the ex vivo perfused canine ileum.

1994 • 7 citations

A selective NK‐2 antagonist blocks the increase of canine colonic tone and ileal contractions induced by the NK‐2 selective receptor agonist, [βAla⁸] neurokinin A‐(4–10)

1994 • 7 citations

Tachykinin-stimulated small bowel myoelectric pattern: sensitization by NO inhibition, reversal by neurokinin receptor blockade

2002 • 5 citations

Effect of tachykinins on the acetylcholine output stimulated by nicotine from guinea-pig bladder

1993 • 3 citations