Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon

Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.

1991 • 1,760 citations

Proteinase-activated Receptors

2006 • 1,166 citations

A dual thrombin receptor system for platelet activation

1998 • 972 citations

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

2000 • 926 citations

Cloning and characterization of human protease-activated receptor 4

1998 • 807 citations

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

1999 • 802 citations

Proteinase-activated receptors: novel mechanisms of signaling by serine proteases

1998 • 785 citations

Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities

2002 • 549 citations

Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves

1995 • 463 citations

Cathepsin G Activates Protease-activated Receptor-4 in Human Platelets

2000 • 328 citations

Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.

1997 • 290 citations

Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides

1997 • 240 citations

Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides

2000 • 205 citations

Characterization of Antisera Specific to NK1, NK2, and NK3 Neurokinin Receptors and their Utilization to Localize Receptors in the Rat Gastrointestinal Tract

1996 • 203 citations

Rat proteinase‐activated receptor‐2 (PAR‐2): cDNA sequence and activity of receptor‐derived peptides in gastric and vascular tissue

1996 • 200 citations

Thrombin and mast cell tryptase regulate guinea‐pig myenteric neurons through proteinase‐activated receptors‐1 and −2

1999 • 188 citations

Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2

1999 • 182 citations

Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH₂, in rat vascular and gastric smooth muscle

1995 • 166 citations

Proteinase-activated receptor 2 (PAR ₂ )-activating peptides: Identification of a receptor distinct from PAR ₂ that regulates intestinal transport

1998 • 153 citations

Review article: proteinase‐activated receptors — novel signals for gastrointestinal pathophysiology

2000 • 134 citations

Presence and Bronchomotor Activity of Protease-Activated Receptor-2 in Guinea Pig Airways

2000 • 114 citations

Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle

1999 • 103 citations

Proteinase‐activated receptor‐2 (PAR‐2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice

2000 • 98 citations

Expression of Protease-Activated Receptor-1, -2, -3, and -4 in Control and Experimentally Inflamed Mouse Bladder

2003 • 93 citations

Protease-Activated Receptors and Platelet Function

1999 • 86 citations

In vivo evidence that protease‐activated receptors 1 and 2 modulate gastrointestinal transit in the mouse

2001 • 75 citations

Modulation by protease‐activated receptors of the rat duodenal motility in vitro: possible mechanisms underlying the evoked contraction and relaxation

1999 • 75 citations

Intestinal type 2 proteinase-activated receptors: expression in opioid-sensitive secretomotor neural circuits that mediate epithelial ion transport.

2000 • 66 citations

Modulation of airway smooth muscle tone by protease activated receptor‐1,‐2,‐3 and ‐4 in trachea isolated from influenza A virus‐infected mice

2000 • 63 citations

Evidence for functionally active protease‐activated receptor‐4 (PAR‐4) in human vascular smooth muscle cells

2001 • 58 citations

Proteinase-activated receptor 4 (PAR₄): action of PAR₄-activating peptides in vascular and gastric tissue and lack of cross-reactivity with PAR₁ and PAR₂

1999 • 58 citations

Dual effect mediated by protease‐activated receptors on the mechanical activity of rat colon

2002 • 51 citations

Effect of protease‐activated receptor (PAR)‐1, −2 and −4‐activating peptides, thrombin and trypsin in rat isolated airways

2000 • 50 citations

Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidyl inositol 3'-kinase.

1998 • 49 citations

Trypsin-induced, Neurokinin-mediated Contraction of Guinea Pig Bronchus

2000 • 42 citations

Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease‐activated receptors (PARs): a novel role for PAR‐4 as opposed to PAR‐1

2000 • 40 citations

Signal Transduction Pathways Involved in the Mechanical Responses to Protease-Activated Receptors in Rat Colon

2002 • 33 citations

Involvement of nitric oxide and tachykinins in the effects induced by protease‐activated receptors in rat colon longitudinal muscle

2003 • 31 citations

Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle

2000 • 30 citations

Involvement of tachykinin NK₂ receptors in the modulation of spontaneous motility in rat proximal colon

2000 • 25 citations

Evidence that PAR‐1 and PAR‐2 mediate prostanoid‐dependent contraction in isolated guinea‐pig gallbladder

2000 • 22 citations

Tachykinins mediate noncholinergic excitatory neural responses in the circular muscle of rat proximal colon

1998 • 14 citations

Tachykinins mediate noncholinergic excitatory neural responses in the circular muscle of rat proximal colon

1998 • 12 citations

Canadian Association of Gastroenterology

2010 • 1 citations