Altered Response of Intestinal Mucosal Fibroblasts to Profibrogenic Cytokines in Inflammatory Bowel Disease

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)

1995 • 1,103 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group

1997 • 493 citations

Myofibroblasts differentiate from fibroblasts when plated at low density.

1996 • 482 citations

Long-term follow-up of patients with Crohn's disease

1986 • 397 citations

AN ANALYSIS OF COLLAGEN SECRETION BY ESTABLISHED MOUSE FIBROBLAST LINES

1964 • 356 citations

Evidence of Fibroblast Heterogeneity and the Role of Fibroblast Subpopulations in Fibrosis

1994 • 343 citations

Macrophage-derived angiogenesis factors

1991 • 325 citations

Collagen content and types in the intestinal strictures of Crohn's disease

1988 • 321 citations

Incidence and Prevalence of Crohn's Disease in the County of Copenhagen, 1962-87: A Sixfold Increase in Incidence

1992 • 314 citations

Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma.

1995 • 311 citations

Induction of alpha-smooth muscle actin expression and myofibroblast transformation in cultured corneal keratocytes.

1996 • 299 citations

Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation.

1988 • 247 citations

Modulation of fibroblast functions by interleukin 1: increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and beta

1988 • 243 citations

Heterogeneous Proliferative Characteristics of Human Adult Lung Fibroblast Lines and Clonally Derived Fibroblasts from Control and Fibrotic Tissue

1988 • 228 citations

Induction of ??-Smooth Muscle Actin Expression and Myofibroblast Transformation in Cultured Corneal Keratocytes

1996 • 213 citations

Regulation of cell movement: the motogenic cytokines

1991 • 199 citations

Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn's disease

1992 • 190 citations

IL-1 stimulates intestinal myofibroblast COX gene expression and augments activation of Cl- secretion in T84 cells

1996 • 170 citations

Mechanisms of pathogenesis in scleroderma. I. Overproduction of interleukin 6 by fibroblasts cultured from affected skin sites of patients with scleroderma.

1992 • 148 citations

Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa—implications for pathogenesis

1995 • 145 citations

Collagenase Production Is Lower in Post-Burn Hypertrophic Scar Fibroblasts Than in Normal Fibroblasts and Is Reduced by Insulin-Like Growth Factor-1

1996 • 144 citations

Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2

1997 • 144 citations

Biochemical Characterization and Quantitation of the Collagenous Components of Urethral Stricture Tissue

1993 • 140 citations

Inflammation Location, But Not Type, Determines the Increase in TGF-β1 and IGF-1 Expression and Collagen Deposition in IBD Intestine

2001 • 126 citations

Human fibroblasts produce granulocyte-CSF, macrophage-CSF, and granulocyte-macrophage-CSF following stimulation by interleukin-1 and poly(rI).poly(rC)

1988 • 124 citations

Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts.

1995 • 117 citations

Differences between adult and foetal fibroblasts in the regulation of hyaluronate synthesis: correlation with migratory activity

1989 • 116 citations

Collagen synthesis by human intestinal smooth muscle cells in culture

1987 • 113 citations

IGF-I and procollagen α1(I) are coexpressed in a subset of mesenchymal cells in active Crohn's disease

2000 • 112 citations

Effects of the cytokines on the proliferation of and collagen synthesis by human cataract lens epithelial cells.

1996 • 102 citations

Cellular localization of procollagen gene transcripts in inflammatory bowel diseases

1992 • 99 citations

Functional switching of macrophage responses to tumor necrosis factor-alpha (TNF alpha) by interferons. Implications for the pleiotropic activities of TNF alpha.

1994 • 99 citations

Increased Expression of Platelet-Derived Growth Factor A and Insulin-Like Growth Factor-I in BAL Cells During the Development of Bleomycin-Induced Pulmonary Fibrosis in Mice

1996 • 97 citations

Human fibroblasts produce granulocyte-CSF, macrophage-CSF, and granulocyte-macrophage-CSF following stimulation by interleukin-1 and poly(rI).poly(rC)

1988 • 97 citations

The long-term outcome in Crohn's disease

1987 • 96 citations

Characteristics of human "fibroblasts" cultivated in vitro from different anatomical sites.

1962 • 94 citations

Effects of Activin A on Proliferation and Differentiation of Human Lung Fibroblasts

1996 • 89 citations

Growth Factor Effects on the Expression of Collagenase and TIMP‐1 in Periodontal Ligament Cells

1995 • 72 citations

The fibroblast-like nature of myofibroblast

1988 • 68 citations

The ultrastructure of smooth muscle tumors with a consideration of the possible relationship of glomangiomas, hemangiopericytomas, and cardiac myxomas.

1975 • 62 citations

Intracellular actin as a marker for myofibroblasts in vitro.

1992 • 57 citations

Risk of Recurrence and Reoperation after Resection for Ileocolic Crohn's Disease

1991 • 57 citations

Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts

1995 • 53 citations

Phenotypic heterogeneity in breast fibroblasts: Functional anomaly in fibroblasts from histologically normal tissue adjacent to carcinoma

1994 • 50 citations

Ulcerative proctitis in central Sweden 1965?1983

1991 • 48 citations

Role of water and electrolyte influxes in anoxic plasma membrane disruption

1997 • 44 citations

Instability of the myofibroblast phenotype in culture

1990 • 38 citations

Cell Structure: An Introduction to Biological Electron Microscopy

1968 • 24 citations

Mechanism of Regulation of fibroblastic cell replication. IV. An analysis of the serum dependence of cell replication based on michaelis-menten kinetics

1977 • 23 citations

A tumor of myofibroblasts

1983 • 18 citations