Potent vasoconstrictor actions of cyclopiazonic acid and thapsigargin on femoral arteries from spontaneously hypertensive rats

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Cyclopiazonic Acid is a Specific Inhibitor of the Ca2+-ATPase of Sarcoplasmic Reticulum

1989 • 750 citations

Cellular Mechanisms Regulating [Ca2+]i Smooth Muscle

1989 • 433 citations

Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator fura 2.

1988 • 298 citations

Superficial buffer barrier function of smooth muscle sarcoplasmic reticulum

1995 • 253 citations

Calcium requirement for activation of intact aortic smooth muscle

1977 • 202 citations

Electrogenesis of increased norepinephrine sensitivity of arterial vascular muscle in hypertension.

1976 • 197 citations

Simultaneous recordings of calcium signals and mechanical activity using fluorescent dye fura 2 in isolated strips of vascular smooth muscle.

1987 • 160 citations

Effects of cyclopiazonic acid, a novel Ca²⁺‐ATPase inhibitor, on contractile responses in skinned ileal smooth muscle

1992 • 140 citations

Ryanodine modulation of45Ca efflux and tension in rabbit aortic smooth muscle

1987 • 118 citations

Contribution of two types of calcium channels to membrane conductance of single myocytes from guinea‐pig coronary artery.

1990 • 112 citations

Dysfunction of calcium handling by smooth muscle in hypertension

1985 • 100 citations

The superficial buffer barrier in vascular smooth muscle

1992 • 99 citations

Altered calcium sequestration by subcellular fractions of vascular smooth muscle from spontaneously hypertensive rats

1976 • 95 citations

Vascular Smooth Muscle Membrane in Hypertension

1988 • 94 citations

NMR measurement of cytosolic free calcium, free magnesium, and intracellular sodium in the aorta of the normal and spontaneously hypertensive rat.

1990 • 86 citations

Calcium fluxes, calcium binding, and adenosine cyclic 3',5'-monophosphate-dependent protein kinase activity in the aorta of spontaneously hypertensive and Kyoto Wistar normotensive rats.

1978 • 83 citations

Inhibition of L-type calcium-channel activity by thapsigargin and 2,5-t-butylhydroquinone, but not by cyclopiazonic acid

1994 • 80 citations

Energy-dependent calcium uptake activity of microsomes from the aorta of normal and hypertensive rats

1975 • 79 citations

Cytosolic free calcium of aorta in hypertensive rats. Chronic inhibition of angiotensin converting enzyme.

1990 • 79 citations

Charybdotoxin‐sensitive K⁺ channels regulate the myogenic tone in the resting state of arteries from spontaneously hypertensive rats

1993 • 79 citations

Cyclopiazonic acid is a sarcoplasmic reticulum Ca(2+)-pump inhibitor of rat aortic muscle.

1991 • 76 citations

Ca2+ regulation of vascular smooth muscle.

1986 • 74 citations

Cyclopiazonic acid, an inhibitor of Ca²⁺‐ATPase in sarcoplasmic reticulum, increases excitability in ileal smooth muscle

1993 • 69 citations

Increased function of voltage-dependent Ca++ channels and Ca(++)-activated K+ channels in resting state of femoral arteries from spontaneously hypertensive rats at prehypertensive stage.

1995 • 66 citations

Sarcoplasmic reticulum calcium transport and Ca(2+)-ATPase gene expression in thoracic and abdominal aortas of normotensive and spontaneously hypertensive rats.

1993 • 63 citations

Thapsigargin inhibits voltage-activated calcium channels in adrenal glomerulosa cells

1993 • 59 citations

Thapsigargin inhibits repletion of phenylephrine-sensitive intracellular Ca++ pool in vascular smooth muscles.

1991 • 53 citations

Evidence for reduced β‐adrenoceptor coupling to adenylate cyclase in femoral arteries from spontaneously hypertensive rats

1988 • 52 citations

Membrane potential of vascular smooth muscle and hypertension in spontaneously hypertensive rats

1984 • 50 citations

Evidence for a direct interaction of thapsigargin with voltage-dependent Ca2+ channel

1995 • 49 citations

Functional role of charybdotoxin-sensitive K+ channels in the resting state of cerebral, coronary and mesenteric arteries of the dog.

1993 • 48 citations

Small vessel membrane potential, sympathetic input, and electrogenic pump rate in SHR

1986 • 47 citations

Effects of cyclopiazonic acid and thapsigargin on electromechanical activities and intracellular Ca²⁺ in smooth muscle of carotid artery of hypertensive rats

1996 • 45 citations

Contractile effects of Bay k 8644, a dihydropyridine calcium agonist, on isolated femoral arteries from spontaneously hypertensive rats.

1986 • 41 citations

Effect of the Ca²⁺‐ATPase inhibitor, cyclopiazonic acid, on electromechanical coupling in the guinea‐pig ureter

1995 • 41 citations

Recycling and buffering of intracellular calcium in vascular smooth muscle from genetically hypertensive rats

1994 • 40 citations

The relationship between noradrenaline‐induced contraction and ⁴⁵Ca efflux stimulation in rabbit mesenteric artery

1986 • 39 citations

Calcium Flux and Binding in the Aortic Smooth Muscle from the Spontaneously Hypertensive Rat

1975 • 32 citations

Effects of Thapsigargin in Isolated Rat Thoracic Aorta

1988 • 29 citations

Possible mechanism of the potent vasoconstrictor actions of ryanodine on femoral arteries from spontaneously hypertensive rats

1996 • 28 citations

Increased resting Ca2+ maintains the myogenic tone and activates K+ channels in arteries from young spontaneously hypertensive rats

1993 • 25 citations

Comparison of effects of cromakalim and pinacidil on mechanical activity and 86Rb efflux in dog coronary arteries.

1990 • 21 citations

Functional Alterations in the Aorta of the Spontaneously Hypertensive Rat: Pharmacological Assessment with Cyclopiazonic Acid

1993 • 15 citations

Modification by cyclopiazonic acid and ryanodine of depolarization-induced constriction in rat mesenteric artery

1994 • 12 citations

Age-dependent increase in arterial smooth muscle calcium in spontaneously hypertensive rats

1988 • 10 citations

The relationship between noradrenaline-induced tension development and stimulated ^ Ca efflux in rabbit mesenteric small artery

1986 • 10 citations

Deleted Work

1955 • 0 citations