Inhibition of L-type calcium-channel activity by thapsigargin and 2,5-t-butylhydroquinone, but not by cyclopiazonic acid

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

1991 • 1,282 citations

Two Ca2+ ATPase genes: Homologies and mechanistic implications of deduced amino acid sequences

1986 • 812 citations

Establishment of Clonal Strains of Rat Pituitary Tumor Cells That Secrete Growth Hormone^1,2

1968 • 683 citations

Fluorescence and bioluminescence measurement of cytoplasmic free calcium

1987 • 522 citations

The Inositol Phosphate-Calcium Signaling System in Nonexcitable Cells

1993 • 505 citations

Oscillations of cytosolic Ca2+ in pituitary cells due to action potentials

1987 • 331 citations

Spatial and temporal aspects of cell signalling

1988 • 278 citations

Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells.

1992 • 271 citations

Coupling between intracellular Ca2+ stores and the Ca2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di-(tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes.

1991 • 243 citations

Inositol 1,4,5-Trisphosphate-Activated Calcium Channels

1992 • 236 citations

2,5‐Di(tert‐butyl)‐1,4‐benzohydroquinone — a novel inhibitor of liver microsomal Ca²⁺ sequestration

1987 • 204 citations

Calcium Oscillations in Anterior Pituitary Cells

1992 • 159 citations

Regulation of extracellular calcium entry in endothelial cells: role of intracellular calcium pool

1992 • 135 citations

Bidirectional control of cytosolic free calcium by thyrotropin-releasing hormone in pituitary cells

1985 • 135 citations

A conformational mechanism for formation of a dead-end complex by the sarcoplasmic reticulum ATPase with thapsigargin.

1992 • 127 citations

Nucleotide sequences of avian cardiac and brain SR/ER Ca(2+)-ATPases and functional comparisons with fast twitch Ca(2+)-ATPase. Calcium affinities and inhibitor effects

1991 • 101 citations

Ca2+ extrusion across plasma membrane and Ca2+ uptake by intracellular stores

1991 • 99 citations

The inhibitors thapsigargin and 2,5‐di(tert‐butyl)‐1,4‐benzohydroquinone favour the E2 form of the Ca²⁺, Mg²⁺‐ATPase

1992 • 96 citations

Inositol 1,4,5-trisphosphate-mediated quantal Ca2+ release measured by high resolution imaging of Ca2+ within organelles.

1993 • 86 citations

Ca2+ influx induced by the Ca2+-ATPase inhibitors 2,5-di-(t-butyl)-1,4-benzohydroquinone and thapsigargin in bovine adrenal chromaffin cells

1992 • 69 citations

The Ca2+-transport ATPases from the plasma membrane

1992 • 64 citations

The Capacitative Model for Receptor-Activated Calcium Entry

1991 • 64 citations

Functional identification and quantitation of three intracellular calcium pools in GH4C1 cells: Evidence that the caffeine-responsive pool is coupled to a thapsigargin-resistant, ATP-dependent process

1993 • 59 citations

Voltage‐gated and agonist‐mediated rises in intracellular Ca2+ in rat clonal pituitary cells (GH3) held under voltage clamp.

1989 • 50 citations

Mechanism of spontaneous intracellular calcium fluctuations in single GH4C1 rat pituitary cells

1993 • 50 citations

Long‐Range Intramolecular Linked Functions in Activation and Inhibition of SERCA ATPases^a

1992 • 32 citations

Pituitary Ca2+ channels: blockade by conventional and novel Ca2+ antagonists

1987 • 24 citations

Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels.

1992 • 19 citations

Regulation of L-type voltage-gated calcium channels by epidermal growth factor.

1993 • 19 citations

Role of inositol lipid second messengers in regulation of secretion: studies of thyrotropin-releasing hormone action in pituitary cells.

1989 • 15 citations