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1996 • 2,032 citations

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Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

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Persistent inhibition of cell respiration by nitric oxide: Crucial role ofS-nitrosylation of mitochondrial complex I and protective action of glutathione

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Molecular mechanisms and therapeutic strategies related to nitric oxide

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CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

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Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages.

1993 • 540 citations

Macrophage-Derived Nitric Oxide Regulates T Cell Activation via Reversible Disruption of the Jak3/STAT5 Signaling Pathway

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Type 1 Interferon (IFNα/β) and Type 2 Nitric Oxide Synthase Regulate the Innate Immune Response to a Protozoan Parasite

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Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

1994 • 367 citations

FAS Engagement Induces the Maturation of Dendritic Cells (Dcs), the Release of Interleukin (Il)-1β, and the Production of Interferon γ in the Absence of IL-12 during Dc–T Cell Cognate Interaction

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Regulation of interleukin-12 production in antigen-presenting cells

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Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages

1998 • 211 citations

Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis.

1996 • 210 citations

Requirement for Type 2 NO Synthase for IL-12 Signaling in Innate Immunity

1999 • 198 citations

Rapidly Fatal Leishmaniasis in Resistant C57BL/6 Mice Lacking TNF

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Effects of nitric oxide on the induction and differentiation of Th1 cells

1999 • 155 citations

Dendritic cells with immature phenotype and defective function in the peripheral blood from patients with hepatocellular carcinoma

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Successful Therapy of Lethal Murine Visceral Leishmaniasis with Cystatin Involves Up-Regulation of Nitric Oxide and a Favorable T Cell Response

2001 • 116 citations

Nitric oxide inhibits tumor necrosis factor-α-induced apoptosis by reducing the generation of ceramide

2000 • 108 citations

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2001 • 89 citations

Thymic Dendritic Cells Express Inducible Nitric Oxide Synthase and Generate Nitric Oxide in Response to Self- and Alloantigens

2000 • 72 citations

Activation of p38 Mitogen-activated Protein Kinase by Lipopolysaccharide in Human Neutrophils Requires Nitric Oxide-dependent cGMP Accumulation

1999 • 66 citations

Increased nitric oxide (NO) production by antigen-presenting dendritic cells is responsible for low allogeneic mixed leucocyte reaction (MLR) in primary biliary cirrhosis (PBC)

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Interleukin‐lβ, tumor necrosis factor‐α, and LPS enhance calcium channel current in isolated vascidar smooth muscle cells of rat tail artery

1996 • 54 citations

Nitric Oxide Inhibits the Tumor Necrosis Factor α-regulated Endocytosis of Human Dendritic Cells in a Cyclic GMP-dependent Way

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Anti-IL-4 antibody therapy causes regression of chronic lesions caused by medium-doseLeishmania major infection in BALB/c mice

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Mechanisms of recovery from experimental allergic encephalomyelitis induced with myelin basic protein peptide 68–86 in Lewis rats: a role for dendritic cells in inducing apoptosis of CD4+ T cells

1999 • 38 citations

Cycling of human dendritic cell effector phenotypes in response to TNF‐α: modification of the current ‘maturation’ paradigm and implications forin vivoimmunoregulation

1999 • 38 citations

Generation of nitric oxide by the inducible nitric oxide synthase protects gamma delta T cells from Mycobacterium tuberculosis-induced apoptosis.

1999 • 38 citations

Continuous exposure to high concentrations of nitric oxide leads to persistent inhibition of oxygen consumption by J774 cells as well as extraction of oxygen by the extracellular medium

2000 • 38 citations

Cyclic GMP and guanylate cyclase mediate lipopolysaccharide-induced Kupffer cell tumor necrosis factor-α synthesis

1995 • 29 citations

Generation of Nitric Oxide by the Inducible Nitric Oxide Synthase Protects γδ T Cells fromMycobacterium tuberculosis-Induced Apoptosis

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Monoreactive and Polyreactive Rheumatoid Factors Produced by in Vitro Epstein‐Barr Virus‐Transformed Peripheral Blood and Synovial B Lymphocytes from Rheumatoid Arthritis Patients

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In vitro indomethacin administration upregulates interleukin‐12 production and polarizes the immune response towards a Th1 type in susceptible BALB/c mice infected with Leishmania mexicana

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Early Events Controlling T-Helper Cell Differentiation: The Role of the IL-12 Receptor

1997 • 16 citations

NADPH diaphorase‐positive dendritic profiles in rat thymus are discrete from autofluorescent cells, immunoreactive for inducible nitric oxide synthase, and show strain‐specific abundance differences

1998 • 6 citations