A Reproducible Model of Middle Cerebral Artery Occlusion in Mice: Hemodynamic, Biochemical, and Magnetic Resonance Imaging

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

A Semiautomated Method for Measuring Brain Infarct Volume

1990 • 1,610 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Perfusion imaging

1992 • 1,497 citations

Magnetic resonance imaging of perfusion using spin inversion of arterial water.

1992 • 1,497 citations

Viability thresholds and the penumbra of focal ischemia

1994 • 1,358 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

1986 • 1,257 citations

Role of Oxidants in Ischemic Brain Damage

1996 • 1,037 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Experimental studies of ischemic brain edema

1986 • 932 citations

Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

1996 • 713 citations

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

1994 • 571 citations

Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke.

1996 • 521 citations

Theoretical Model for Water Diffusion in Tissues

1995 • 518 citations

Reduced Brain Edema and Infarction Volume in Mice Lacking the Neuronal Isoform of Nitric Oxide Synthase after Transient MCA Occlusion

1996 • 422 citations

Ischemic Thresholds of Cerebral Protein Synthesis and Energy State following Middle Cerebral Artery Occlusion in Rat

1991 • 337 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

Evolution of Regional Changes in Apparent Diffusion Coefficient during Focal Ischemia of Rat Brain: The Relationship of Quantitative Diffusion NMR Imaging to Reduction in Cerebral Blood Flow and Metabolic Disturbances

1995 • 301 citations

Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area

1986 • 294 citations

Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat

1996 • 247 citations

Expression of c‐fos and c‐jun family genes after focal cerebral ischemia

1993 • 222 citations

Procedural and Strain-related Variables Significantly Affect Outcome in a Murine Model of Focal Cerebral Ischemia

1996 • 220 citations

Diffusion-Weighted Magnetic Resonance Imaging of Acute Focal Cerebral Ischemia: Comparison of Signal Intensity with Changes in Brain Water and Na⁺,K⁺-ATPase Activity

1994 • 212 citations

A pictorial representation of endogenous brain ATP by a bioluminescent method

1978 • 154 citations

Expression of transforming growth factor-?1 and interleukin-1? mRNA in rat brain following transient forebrain ischemia

1993 • 150 citations

Induction of c-Fos, junB, c-Jun, and hsp70 mRNA in Cortex, Thalamus, Basal Ganglia, and Hippocampus following Middle Cerebral Artery Occlusion

1994 • 150 citations

The stress gene response in brain.

1996 • 143 citations

The concepts of thresholds of ischaemia in relation to brain structure and function.

1977 • 142 citations

Differential Expression of the Immediate Early Genes c-Fos, c-Jun, JunB, andNGFI-B in the Rat Brain following Transient Forebrain Ischemia

1994 • 128 citations

Diffusion and perfusion MR imaging of cerebral ischemia.

1995 • 128 citations

Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the ‘penumbra’ following focal cerebral ischemia in the rat

1993 • 126 citations

Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia

1993 • 126 citations

The Heat Shock/Stress Response in Focal Cerebral Ischemia

1994 • 114 citations

Clinical Aspects of DWI

1995 • 90 citations

Stimulus‐Transcription Coupling in Focal Cerebral Ischemia

1994 • 86 citations

Ultrafast Perfusion-Weighted MRI of Functional Brain Activation in Rats During Forepaw Stimulation: Comparison withT*2-Weighted MRI

1996 • 82 citations

The Effect of Hypothermia on Transient Focal Ischemia in Rat Brain Evaluated by Diffusion- and Perfusion-Weighted NMR Imaging

1994 • 75 citations

Regional changes in tissue pH and glucose content during cortical spreading depression in rat brain

1985 • 72 citations

Threshold relationship between cerebral blood flow, glucose utilization, and energy metabolites during development of stroke in gerbils

1992 • 70 citations

Expression of c-fos mRNA after a mild focal cerebral ischemia in SOD-1 transgenic mice

1994 • 40 citations

Threshold of calcium disturbances after focal cerebral ischemia in rats. Implications of the window of therapeutic opportunity.

1993 • 39 citations

Transgenic and knockout mice in the study of neurodegenerative diseases

1996 • 32 citations

Gene knockout mice as investigative tools in pathophysiology

1996 • 15 citations

A new gerbil model of hindbrain ischemia by extracranial occlusion of the bilateral vertebral arteries

1994 • 11 citations