The Role of Iron in Parkinson Disease and 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Toxicity

The ferritins: molecular properties, iron storage function and cellular regulation

1996 • 2,572 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1997 • 1,304 citations

Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease

1989 • 1,117 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases?

1994 • 701 citations

Understanding cell death in parkinson's disease

1998 • 678 citations

Iron and Aluminum Increase in the Substantia Nigra of Patients with Parkinson's Disease: An X‐Ray Microanalysis

1991 • 518 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1992 • 457 citations

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

1992 • 450 citations

Oxidative damage in neurodegenerative disease

1994 • 428 citations

Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

1992 • 423 citations

An introduction to the free radical hypothesis in Parkinson's disease

1992 • 385 citations

Conjugates of Catecholamines with Cysteine and GSH in Parkinson's Disease: Possible Mechanisms of Formation Involving Reactive Oxygen Species

1998 • 366 citations

A Quantitative Analysis of Isoferritins in Select Regions of Aged, Parkinsonian, and Alzheimer's Diseased Brains

1995 • 320 citations

Increased iron‐related MRI contrast in the substantia nigra in Parkinson's disease

1995 • 317 citations

Decreased Ferritin Levels in Brain in Parkinson's Disease

1990 • 254 citations

Complex I, Iron, and ferritin in Parkinson's disease substantia nigra

1994 • 239 citations

Increased Basal Ganglia Iron Levels in Huntington Disease

1999 • 183 citations

In Vitro Studies of Ferritin Iron Release and Neurotoxicity

1998 • 152 citations

Understanding Parkinson's Disease

1997 • 146 citations

The history of iron in the brain

1995 • 136 citations

Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys

1994 • 133 citations

Regional Metal Concentrations in Parkinson's Disease, Other Chronic Neurological Diseases, and Control Brains

1989 • 131 citations

Depletion of glutathione in brainstem of mice caused by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is prevented by antioxidant pretreatment

1986 • 125 citations

Effect of ferritin-containing fractions with different iron loading on lipid peroxidation

1983 • 114 citations

Manganese: A transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of Parkinsonism

1998 • 106 citations

Excessive iron accumulation in the brain: A possible potential risk of neurodegeneration in Parkinson's disease

1997 • 100 citations

Original Papers: ON THE OCCURRENCE OF ABNORMAL DEPOSITS OF IRON IN THE BRAIN IN PARKINSONISM WITH SPECIAL REFERENCE TO ITS LOCALISATION.

1924 • 97 citations

The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals

1985 • 96 citations

Distribution of iron in different brain regions and subcellular compartments in Parkinson's disease

1992 • 87 citations

Basal ganglia iron content in Parkinson's disease measured with magnetic resonance

1996 • 86 citations

Activated microglia cause superoxide-mediated release of iron from ferritin

1995 • 85 citations

The Potential Role of Iron Chelators in the Treatment of Parkinson's Disease and Related Neurological Disorders

1997 • 77 citations

Brain iron: location and function.

1993 • 63 citations

Iron‐mediated bioactivation of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) in glial cultures

1995 • 43 citations

Structural and Functional Studies of Human Ferritin H and L Chains1

2015 • 39 citations

Abnormalities in Iron Metabolism in Multiple Sclerosis

1989 • 37 citations

Topographical localization of iron in brains of the aged fat-tailed dwarf lemur(Cheirogaleus medius) and gray lesser mouse lemur(Microcebus murinus)

1998 • 28 citations