Positional and additive effects of basic amino acids on processing of precursor proteins within the constitutive secretory pathway

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

The new enzymology of precursor processing endoproteases.

1992 • 608 citations

Post-Translational Proteolysis in Polypeptide Hormone Biosynthesis

1982 • 590 citations

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1991 • 590 citations

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

1991 • 589 citations

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes.

1991 • 317 citations

Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

1991 • 268 citations

Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes

1990 • 259 citations

Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.

1992 • 249 citations

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.

1990 • 219 citations

Identification and Functional Expression of a New Member of the Mammalian Kex2-Like Processing Endoprotease Family: Its Striking Structural Similarity to PACE41

1993 • 185 citations

Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells.

1992 • 156 citations

Consensus sequence for precursor processing at mono-arginyl sites. Evidence for the involvement of a Kex2-like endoprotease in precursor cleavages at both dibasic and mono-arginyl sites.

1992 • 116 citations

Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces, cerevisiae

1989 • 114 citations

Sequence requirements for precursor cleavage within the constitutive secretory pathway.

1992 • 113 citations

Molecular and Enzymatic Properties of Furin, a Kex2-Like Endoprotease Involved in Precursor Cleavage at Arg-X-Lys/Arg-Arg Sites1

1992 • 100 citations

Cloning and Functional Expression of a Novel Endoprotease Involved in Prohormone Processing at Dibasic Sites1

1991 • 96 citations

Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif.

1992 • 87 citations

Endoproteolytic processing of the dibasic cleavage site in the human protein C precursor in transfected mammalian cells: effects of sequence alterations on efficiency of cleavage

1990 • 60 citations

Tissue Distribution and Molecular Heterogeneity of Human Growth Hormone-Releasing Factor in the Transgenic Mouse

1990 • 24 citations

Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis.

1990 • 16 citations

Purification of Mouse Ren 2 Prorenin Produced in Chinese Hamster Ovary Cells1

1990 • 12 citations