Bone marrow-derived macrophage lines and immortalized cloned macrophage and dendritic cells support priming of Borrelia burgdorferi — specific T cell responses in vitro and/or in vivo

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Lyme Disease—a Tick-Borne Spirochetosis?

1982 • 2,831 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Lyme Disease

1989 • 1,169 citations

Antigen-Presenting Function of the Macrophage

1984 • 1,164 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Fundamental Immunology

1994 • 903 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine

1989 • 632 citations

Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens

1978 • 589 citations

Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA

1990 • 480 citations

Lyme Borreliosis in Selected Strains and Ages of Laboratory Mice

1990 • 446 citations

Seronegative Lyme Disease

1988 • 379 citations

Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.

1986 • 374 citations

The T-Cell Proliferative Assay in the Diagnosis of Lyme Disease

1991 • 287 citations

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements.

1992 • 239 citations

Isolated human follicular dendritic cells display a unique antigenic phenotype.

1989 • 225 citations

Low-passage-associated proteins of Borrelia burgdorferi B31: characterization and molecular cloning of OspD, a surface-exposed, plasmid-encoded lipoprotein

1992 • 223 citations

Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete.

1983 • 191 citations

Recombinant Outer Surface Protein A from Borrelia burgdorferi Induces Antibodies Protective against Spirochetal Infection in Mice

1991 • 185 citations

Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells during primary antibody responses in vitro.

1984 • 180 citations

Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease

1994 • 180 citations

In vitro evidence that Langerhans cells can adopt two functionally distinct forms capable of antigen presentation to T lymphocytes.

1989 • 177 citations

Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice

1992 • 173 citations

Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22kDa protein (pC) in Escherichia coli

1992 • 153 citations

The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis.

1989 • 142 citations

Novel low-molecular-weight synthetic vaccine against foot-and-mouth disease containing a potent B-cell and macrophage activator

1989 • 140 citations

Experimental Borrelia burgdorferi infection in inbred mouse strains: Antibody response and association of H‐2 genes with resistance and susceptibility to development of arthritis

1991 • 108 citations

Immortalized dendritic cell line fully competent in antigen presentation initiates primary T cell responses in vivo.

1993 • 108 citations

An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo

1993 • 94 citations

Immune responses to borrelia burgdorferi in patients with reactive arthritis

1989 • 85 citations

Characterization of Borrelia burgdorferi invasion of cultured endothelial cells

1991 • 76 citations

Biological Activity of Borrelia burgdorferi Antigens^a

1988 • 69 citations

Cellular immune reactivity to recombinant OspA and flagellin from Borrelia burgdorferi in patients with Lyme borreliosis. Complexity of humoral and cellular immune responses.

1992 • 69 citations

T cell proliferation induced by Borrelia burgdorferi in patients with lyme borreliosis. Autologous serum required for optimum stimulation

1991 • 68 citations

Killing of Borrelia burgdorferi by macrophages is dependent on oxygen radicals and nitric oxide and can be enhanced by antibodies to outer surface proteins of the spirochete

1994 • 67 citations

Demonstration of a B-lymphocyte mitogen produced by the Lyme disease pathogen, Borrelia burgdorferi

1992 • 67 citations

Passive immunization prevents induction of Lyme arthritis in LSH hamsters

1990 • 64 citations

Protection against Borrelia burgdorferi infection in SCID mice is conferred by presensitized spleen cells and partially by B but not T cells alone

1994 • 63 citations

Demonstration of antigen-specific T cells and histopathological alterations in mice experimentally inoculated with Borrelia burgdorferi

1989 • 60 citations

Retroviral immortalization of phagocytic and dendritic cell clones as a tool to investigate functional heterogeneity

1994 • 54 citations

Borrelia BurgdorferiUpregulates the Adhesion Molecules E-selectin, P-selectin, ICAM-1 and VCAM-1 on Mouse Endothelioma Cellsin vitro

1994 • 53 citations

Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse

1993 • 50 citations

Nonspecific Proliferative Responses of Murine Lymphocytes to Borrelia burgdorferi Antigens

1992 • 49 citations

T cell responses to polypeptide fractions of Borrelia burgdorferi in patients with lyme arthritis

1991 • 45 citations

Expression of Endothelial Cell Adhesion Molecules in Joints and Heart duringBorrelia burgdorferiInfection of Mice

1994 • 45 citations

Immunization of mice by recombinant OspA preparations and protection against Borrelia burgdorferi infection induced by Ixodes ricinus tick bites

1994 • 41 citations

A 14,000 MW lipoprotein and a glycolipid-like structure of Borrelia burgdorferi induce proliferation and immunoglobulin production in mouse B cells at high frequencies.

1994 • 38 citations

Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors

1994 • 31 citations

Comparison of Borrelia burgdorferi ultrasonicate and whole B. burgdorferi cells as a stimulus for T-Cell proliferation and GM-CSF secretion in vitro

1993 • 13 citations

New tools for investigating macrophage differentiation

1992 • 7 citations

Deleted Work

1955 • 0 citations