Alkylation and cleavage of DNA by carbon-centered radical metabolites

Superoxide Dismutase

1969 • 12,578 citations

DNA Damage and Oxygen Radical Toxicity

1988 • 1,964 citations

Hydrocarbon Bond Dissociation Energies

1982 • 1,961 citations

The Chemical Basis of Radiation Biology

1987 • 1,843 citations

The chemical basis of radiation biology

1987 • 1,788 citations

DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems

1991 • 1,555 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules

1981 • 733 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

Hydroxyl Free Radical Adduct of Deoxyguanosine: Sensitive Detection and Mechanisms of Formation

1986 • 660 citations

Substrate specificity of the Escherichia coli Fpg protein formamidopyrimidine-DNA glycosylase: excision of purine lesions in DNA produced by ionizing radiation or photosensitization

1992 • 597 citations

Chemical determination of free radical-induced damage to DNA

1991 • 523 citations

Assays for 8-hydroxy-2′-deoxyguanosine: A biomarker of in vivo oxidative DNA damage

1991 • 363 citations

CRC Handbook of free radicals and antioxidants in biomedicine

1989 • 337 citations

Mechanism of neocarzinostatin action: role of DNA microstructure in determination of chemistry of bistranded oxidative damage

1991 • 315 citations

Formation of 8-hydroxy(deoxy)guanosine and generation of strand breaks at guanine residues in DNA by singlet oxygen

1991 • 304 citations

NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).cntdot.dA(anti) alignment at lesion site

1991 • 295 citations

Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column.

1992 • 292 citations

Apurinic sites as mutagenic intermediates

1985 • 283 citations

Peroxyl free radicals: potential mediators of tumor initiation and promotion

1987 • 269 citations

Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane.

1989 • 250 citations

Genotoxicity of active oxygen species in mammalian cells

1988 • 244 citations

Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro.

1987 • 242 citations

Medical, biochemical and chemical aspects of free radicals

1990 • 229 citations

Why is the hydroxyl radical the only radical that commonly adds to DNA? Hypothesis: It has a rare combination of high electrophilicity, high thermochemical reactivity, and a mode of production that can occur near DNA

1988 • 193 citations

The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice

1986 • 181 citations

Role of radical cations in aromatic hydrocarbon carcinogenesis.

1985 • 174 citations

Synthetic and naturally occurring hydrazines as possible cancer causative agents.

1975 • 169 citations

Confirmation of assignment of the trichloromethyl radical spin adduct detected by spin trapping during 13C-carbon tetrachloride metabolism , , , ,

1980 • 165 citations

In vivo formation of a free radical metabolite of ethanol.

1990 • 164 citations

Carbon-13 magnetic resonance spectra of 8-substituted purine nucleosides. Characteristic shifts for the syn conformation

1977 • 158 citations

Generation of oxy radicals in biosystems

1989 • 151 citations

Free radical generation during δ-Aminolevulinic acid autoxidation: Induction by hemoglobin and connections with porphyrinpathies

1989 • 150 citations

The mechanism of oxidation of nitroalkanes by horseradish peroxidase.

1983 • 142 citations

CHEMICAL STRUCTURE AND CARCINOGENICITY OF ALIPHATIC HYDRAZO, AZO, AND AZOXY COMPOUNDS AND OF TRIAZENES, POTENTIAL IN VIVO ALKYLATING AGENTS*

1969 • 137 citations

Mechanism of C8 alkylation of guanine residues by activated arylamines: evidence for initial adduct formation at the N7 position.

1992 • 136 citations

The mutagenicity of hydrazine and some of its derivatives

1977 • 124 citations

NMR and computational characterization of the N-(deoxyguanosin-8-yl)aminofluorene adduct [(AF)G] opposite adenosine in DNA: (AF)G[syn].cntdot.A[anti] pair formation and its pH dependence

1989 • 118 citations

Esperamicins, a class of potent antitumor antibiotics: mechanism of action.

1989 • 117 citations

Synthesis and identification of benzo[a]pyrene-guanine nucleoside adducts formed by electrochemical oxidation and by horseradish peroxidase catalyzed reaction of benzo[a]pyrene with DNA

1988 • 111 citations

The formation of a novel free radical metabolite from CCl4 in the perfused rat liver and in vivo.

1986 • 108 citations

Monosaccharide autoxidation in health and disease.

1985 • 90 citations

Nitroxide Radical Adducts in Biology: Chemistry, Applications, and Pitfalls

1989 • 88 citations

Induction of Cirrhosis of the Liver and of Hepatomas in Mice With Carbon Tetrachloride

1942 • 86 citations

Studies on chemical alterations of nucleic acids and their components—VII

1974 • 77 citations

Light- and .gamma.-ray-induced reactions of purines and purine nucleosides with alcohols

1971 • 75 citations

Golfomycin A, a Novel Designed Molecule with DNA‐Cleaving Properties and Antitumor Activity

1990 • 61 citations

Evidence for the metabolism of tumor promoter organic hydroperoxides into free radicals by human carcinoma skin keratinocytes: an ESR-spin trapping study

1989 • 57 citations

Covalent binding of carbon tetrachloride metabolites to liver nuclear DNA, proteins, and lipids*1, *2

1980 • 56 citations

Free radical-mediated activation of hydrazine derivatives.

1985 • 52 citations

Substitution of p- and o-hydroxyphenyl radicals at the 8 position of purine nucleosides by reaction with mutagenic p- and o-diazoquinones

1992 • 49 citations

Volatile hydrocarbons from hydrogen peroxide-induced lipid peroxidation of erythrocytes and their cell components

1983 • 46 citations

Formation of 8-methylguanine as a result of DNA alkylation by methyl radicals generated during horseradish peroxidase-catalyzed oxidation of methylhydrazine.

1990 • 46 citations

Free-radical-mediated DNA binding.

1985 • 42 citations

Reactivities and electronic aspects of nucleic acid heterocycles. Part 6. Kinetics and mechanism of carbon-8 methylation of purine bases and nucleosides by methyl radical

1977 • 41 citations

Spin-trapping of methyl radical in the oxidative metabolism of 1,2-dimethylhydrazine

1985 • 38 citations

DNA strand breakage by hydroxyphenyl radicals generated from mutagenic diazoquinone compounds

1992 • 38 citations

The Radiation Chemistry of Pyrimidines, Purines and Related Substances

1976 • 36 citations

Iron(III) binding in DNA solutions: Complex formation and catalytic activity in the oxidation of hydrazine derivatives

1991 • 36 citations

In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study

1992 • 34 citations

Ultraviolet and .gamma.-ray-induced free-radical reactions of nucleic acid constituents. Selectivity of some reactions for purines. Suppression of the reactivity of pyrimidines

1976 • 32 citations

Cleavage of DNA resulting from exposure to phenyl radicals

1992 • 31 citations

Identification and quantitation of 7-(benzo[a]pyren-6-yl)guanine in the urine and feces of rats treated with benzo[a]pyrene

1990 • 30 citations

Identification of C8-methylguanine in the hydrolysates of DNA from rats administered 1,2-dimethylhydrazine. Evidence for in vivo DNA alkylation by methyl radicals.

1992 • 29 citations

Thymine Addition to Ethanol: Induction by Gamma Irradiation

1966 • 29 citations

Production of ethane by rats treated with the colon carcinogen, 1,2-dimethylhydrazine

1988 • 28 citations

DNA strand scission by the carbon radical derived from 2-phenyl-ethylhydrazine metabolism

1984 • 28 citations

Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin

1989 • 26 citations

Free-radical chain oxidation of 2-nitropropane initiated and propagated by superoxide

1986 • 26 citations

DNA alterations induced by the carbon-centered radical derived from the oxidation of 2-phenylethylhydrazine

1989 • 25 citations

ENZYMATIC GENERATION OF TRIPLET BIACETYL

1982 • 25 citations

Ethanol induced teratogenesis: Characterization, mechanisms and diagnositic approaches

1989 • 25 citations

THE PHOTOREACTIONS AND FREE RADICAL INDUCED REACTIONS OF 1,3‐DIMETHYLURACIL IN METHANOL AND OTHER ALCOHOLS

1976 • 22 citations

The Reactions of the Hydroxymethyl Radical with 1,3-dimethyluracil and 1,3-dimethylthymine

1986 • 20 citations

Mutation induced in vitro on a C-8 guanine aminofluorene containing template by a modified T7 DNA polymerase

1989 • 16 citations

Hemoglobin-mediated oxidation of the carcinogen 1,2-dimethylhydrazine to methyl radicals

1988 • 16 citations

Reaction of trichloromethyl free radicals with deoxyribonucleic acid bases.

1981 • 15 citations

A radical approach to cancer

1991 • 2 citations

CARBON-CENTERED RADICALS: DNA ALKYLATION AND BIOLOGICAL SOURCES

1991 • 1 citations