Insulin Signaling in Mice Expressing Reduced Levels of Syp

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Teratocarcinomas and embryonic stem cells: A practical approach

1987 • 768 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

1996 • 529 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

1993 • 384 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.

1992 • 359 citations

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development

1995 • 330 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle

1993 • 281 citations

Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains

1995 • 276 citations

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1995 • 263 citations

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.

1994 • 240 citations

Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo

1992 • 238 citations

Genomic DNA microextraction: A method to screen numerous samples

1992 • 221 citations

A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains.

1993 • 219 citations

Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis

1992 • 189 citations

Stimulation of insulin-like growth factor II receptor binding and insulin receptor kinase activity in rat adipocytes. Effects of vanadate and H2O2.

1987 • 148 citations

Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.

1992 • 125 citations

Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C.

1994 • 78 citations

Different Signaling Roles of SHPTP2 in Insulin-induced GLUT1 Expression and GLUT4 Translocation

1995 • 55 citations

Identification of the Major SHPTP2-binding Protein That Is Tyrosine-phosphorylated in Response to Insulin

1995 • 48 citations

Distinct β-subunits are present in hybrid insulin-like-growth-factor-1 receptors in the central nervous system

1993 • 24 citations

Cloning, Expression and Mutational Analysis of SH-PTP2, Human Protein-Tyrosine Phosphatase

1993 • 24 citations

Expression of a Catalytically Inert SYP Blocks Activation of Map Kinase Pathway Downstream of P21ras

1995 • 23 citations

Regulation of Rat Glucagon Receptor Expression

1994 • 20 citations

Evidence Against Dephosphorylation of Insulin-Elicited Phosphotyrosine Proteins in Vivo by the Phosphatase PTP2C

1995 • 14 citations

Rapid Increase in the Insulin Sensitivity of Rat Adipocytes after Intravenous Glucose Administration

1984 • 7 citations

Activation of Chromosomal Vitellogenin Genes in Xenopus Oocytes by Pure Estrogen Receptor and Independent Activation of Albumin Genes

1990 • 7 citations