Preoperative radiotherapy for rectal cancer: implications for surgeons, pathologists and radiologists

TNM Classification of Malignant Tumours

1987 • 16,209 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

The mesorectum in rectal cancer surgery—the clue to pelvic recurrence?

1982 • 2,753 citations

RECURRENCE AND SURVIVAL AFTER TOTAL MESORECTAL EXCISION FOR RECTAL CANCER

1986 • 2,585 citations

Improved Survival with Preoperative Radiotherapy in Resectable Rectal Cancer

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Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations

1994 • 1,915 citations

LOCAL RECURRENCE OF RECTAL ADENOCARCINOMA DUE TO INADEQUATE SURGICAL RESECTION

1986 • 1,912 citations

Effective Surgical Adjuvant Therapy for High-Risk Rectal Carcinoma

1991 • 1,888 citations

Mesorectal excision for rectal cancer

1993 • 1,732 citations

Pathological features of rectal cancer after preoperative radiochemotherapy

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Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

TNM classification of malignant tumours

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p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

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Postoperative Adjuvant Chemotherapy or Radiation Therapy for Rectal Cancer: Results From NSABP Protocol R-011

1988 • 1,025 citations

A NEW PROGNOSTIC CLASSIFICATION OF RECTAL CANCER

1987 • 695 citations

Preoperative Radiotherapy as Adjuvant Treatment in Rectal Cancer

1988 • 667 citations

The Stockholm I trial of preoperative short term radiotherapy in operable rectal carcinoma

1995 • 632 citations

Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum

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Pre- or Postoperative Radiotherapy in Rectal and Rectosigmoid Carcinoma Report from a Randomized Multicenter Trial

1990 • 582 citations

Patterns of recurrence of rectal cancer after potentially curative surgery

1983 • 543 citations

Preoperative irradiation affects functional results after surgery for rectal cancer

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Preoperative short-term radiation therapy in operable rectal carcinoma: A prospective randomized trial

1990 • 372 citations

Enhanced Survival of Patients with Colon and Rectal Cancer is Based Upon Wide Anatomic Resection

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Low rectal cancer

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Randomised trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cancer

1996 • 280 citations

Preoperative irradiation for carcinoma of the rectum and rectosigmoid colon: Report of a national veterans administration randomized study

1975 • 274 citations

Long-term results of a randomised trial of short-course low-dose adjuvant pre-operative radiotherapy for rectal cancer: Reduction in local treatment failure

1994 • 268 citations

Adjuvant preoperative radiotherapy in patients with rectal carcinoma: Adverse effects during long term follow-up of two randomized trials

1996 • 268 citations

Preoperative Radiation and Chemotherapy in the Treatment of Adenocarcinoma of the Rectum

1995 • 265 citations

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1992 • 262 citations

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‘Close shave’ in anterior resection

1990 • 250 citations

Adjuvant preoperative radiotherapy for locally advanced rectal carcinoma

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1977 • 236 citations

Preoperative radiation and surgery for cancer of the rectum: Veterans administration surgical oncology group trial II

1986 • 227 citations

The rationale for preservation of the anal sphincter in patients with low rectal cancer

1984 • 189 citations

Conservative Surgery for Low Rectal Carcinoma After High-Dose Radiation Functional and Oncologic Results

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Preoperative radiotherapy (RT) for rectal cancer: Predictive factors of tumor downstaging and residual tumor cell density (RTCD): Prognostic implications

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Low-dose preoperative radiation postpones recurrences in operable rectal cancer: Results of a randomized multicenter trial in western norway

1990 • 184 citations

Randomised trial of surgery alone versus surgery followed by radiotherapy for mobile cancer of the rectum

1996 • 182 citations

Downstaging of advanced rectal cancer following combined preoperative chemotherapy and high dose radiation

1994 • 181 citations

Effect of anterior resection on anal sphincter function

1989 • 174 citations

Pre-Operative assessment of local invasion in rectal cancer: Digital examination, endoluminal sonography or computed tomography?

1986 • 171 citations

Effect of pelvic radiotherapy for prostate cancer on bowel, bladder, and sexual function: The patient's perspective

1996 • 170 citations

Resectable adenocarcinoma of the rectosigmoid and rectum. I. Patterns of failure and survival

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Randomised trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cancer

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Preoperative Hyperthermia Combined with Radiochemotherapy in Locally Advanced Rectal Cancer

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Local excision of cancer of the rectum

1983 • 156 citations

Accuracy of endosonography in the staging of rectal cancer treated by radiotherapy

1991 • 154 citations

Short-term preoperative radiotherapy results in down-staging of rectal cancer: a study of 1316 patients

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Radiotherapy in addition to radical surgery in rectal cancer: Evidence for a dose-response effect favoring preoperative treatment

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Selection criteria for local excision with or without adjuvant radiation therapy for rectal cancer

1989 • 141 citations

Gastrointestinal and oesophageal pathology

1990 • 140 citations

What affects continence after anterior resection of the rectum?

1991 • 137 citations

Local recurrence after low anterior resection using the staple gun

1982 • 133 citations

Gastrointestinal and oesophageal pathology

1989 • 123 citations

Recurrence and survival after mesorectal excision for rectal cancer

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Rectoanal inhibitory reflex following low stapled anterior resection of the rectum

1992 • 114 citations

Tumor proliferation in rectal cancer following preoperative irradiation.

1995 • 108 citations

Randomised trial of surgery alone versus surgery followed by radiotherapy for mobile cancer of the rectum

1997 • 108 citations

The efficacy of preoperative 5-fluorouracil, high-dose leucovorin, and sequential radiation therapy for unresectable rectal cancer

1993 • 107 citations

Chronic effects of pelvic radiation therapy on anorectal function

1994 • 105 citations

Preoperative staging of irradiated rectal cancers using digital rectal examination, computed tomography, endorectal ultrasound, and magnetic resonance imaging does not accurately predict T0,N0 pathology

1997 • 101 citations

Accuracy of transrectal ultrasound in predicting pathologic stage of rectal cancer before and after preoperative radiation therapy

1992 • 92 citations

Role of p53 and p21/WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients

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High-dose preoperative radiation and full-thickness local excision

1990 • 86 citations

Endorectal ultrasound of T3 and T4 rectal cancers after preoperative chemoradiation

1996 • 74 citations

Preoperative chemoradiation downstages locally advanced ultrasound-staged rectal cancer

1995 • 72 citations

A pilot study of factors influencing bowel function after colorectal anastomosis

1996 • 62 citations

Endocavitary irradiation in the curative treatment of early rectal cancers

1974 • 59 citations

Basic clinical radiobiology for radiation oncologists

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Clinical Evaluation of Nerve-sparing Surgery Combined with Preoperative Radiotherapy in Advanced Rectal Cancer Patients

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Local excision and external beam radiotherapy in early rectal cancer

1996 • 43 citations

Conservative treatment for low rectal carcinoma by local excision with or without radiotherapy

1993 • 42 citations

Preoperative irradiation and colonic healing.

1994 • 40 citations

Is anterior resection of the rectosigmoid safe after preoperative radiation?

1985 • 40 citations

Do Acute Side-Effects During Radiotherapy Predict Tumour Response in Rectal Carcinoma?

1994 • 39 citations

Proliferating cell nuclear antigen and mitotic activity in rectal cancer: predictor of response to preoperative irradiation.

1994 • 36 citations

Effect of preoperative irradiation on healing of low colorectal anastomoses

1984 • 35 citations

Combination preoperative radiation and chemotherapy in adenocarcinoma of the rectum

1976 • 34 citations

Carcinoma of the rectum

1996 • 30 citations

Preoperative radiotherapy for resectable cancer of the middle-distal rectum: its effect on the primary lesion as determined by endorectal ultrasound using flexible echo colonoscope

1996 • 26 citations

Recent Advances in Surgery 5

1996 • 25 citations

Effects of preoperative fractionated irradiation on left colonic anastomoses in the rat

1998 • 25 citations

High-Dose Preoperative Irradiation without Detrimental Effect on Early Repair of Anastomoses in the Colon of the Rat

1997 • 21 citations

Intestinal Anastomotic Healing at Varying Times after Irradiation

1996 • 18 citations

The Year Book of Surgery

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Plea for a preoperative adjuvant approach in the management of rectal cancer

1994 • 11 citations

Adjuvant radiotherapy and anastomosis in rectal cancer—disturbing evidence from animal studies

1995 • 2 citations

Deleted Work

1955 • 0 citations