Antiarrhythmic Effects of Polyunsaturated Fatty Acids

The Lipid Research Clinics Coronary Primary Prevention Trial Results

1984 • 2,673 citations

EFFECTS OF CHANGES IN FAT, FISH, AND FIBRE INTAKES ON DEATH AND MYOCARDIAL REINFARCTION: DIET AND REINFARCTION TRIAL (DART)

1989 • 2,639 citations

Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease

1994 • 2,133 citations

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

The Composition of Food Consumed by Greenland Eskimos

1976 • 964 citations

Dietary Intake and Cell Membrane Levels of Long-Chain n-3 Polyunsaturated Fatty Acids and the Risk of Primary Cardiac Arrest

1995 • 911 citations

Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974.

1980 • 865 citations

A Classification of Antiarrhythmic Actions Reassessed After a Decade of New Drugs

1984 • 808 citations

Epidemiological Studies in the Upernavik District, Greenland

1980 • 691 citations

Intake of Mercury From Fish, Lipid Peroxidation, and the Risk of Myocardial Infarction and Coronary, Cardiovascular, and Any Death in Eastern Finnish Men

1995 • 585 citations

Dietary Intake of Marine n-3 Fatty Acids, Fish Intake, and the Risk of Coronary Disease among Men

1995 • 561 citations

Arachidonic Acid and Other Fatty Acids Directly Activate Potassium Channels in Smooth Muscle Cells

1989 • 353 citations

Potassium Channels in Cardiac Cells Activated by Arachidonic Acid and Phospholipids

1989 • 329 citations

Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes.

1995 • 327 citations

Unbound free fatty acid levels in human serum.

1995 • 310 citations

The Protective Effect of a Small Amount of Fish on Coronary Heart Disease Mortality in an Elderly Population

1995 • 258 citations

Prevention of ischemia-induced ventricular fibrillation by omega 3 fatty acids.

1994 • 254 citations

Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats

1993 • 252 citations

A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis

1992 • 247 citations

Effect of tetrodotoxin on action potentials of the conducting system in the dog heart

1979 • 241 citations

Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes.

1994 • 237 citations

Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes.

1995 • 229 citations

Both membrane stretch and fatty acids directly activate large conductance Ca²⁺‐activated K⁺ channels in vascular smooth muscle cells

1992 • 204 citations

External blockade of the major cardiacdelayed-rectifier K+ channel (Kv1.5) by polyunsaturated fattyacids.

1994 • 200 citations

Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism

1988 • 194 citations

A new era for science in nutrition

1987 • 193 citations

Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey

1992 • 190 citations

Evidence that free polyunsaturated fatty acids modify Na+ channels by directly binding to the channel proteins.

1996 • 185 citations

Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by local anesthetics.

1984 • 176 citations

Influence of dietary lipids on arrhythmias and infarction after coronary artery ligation in rats

1985 • 137 citations

The effect of 5,8,11,14‐eicosatetraynoic acid on lipid metabolism

1979 • 134 citations

Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. I. The filling of individual fatty acid binding sites.

1987 • 125 citations

Regulation of K+ channels in cardiac myocytes by free fatty acids.

1990 • 118 citations

Protective effects of free polyunsaturated fatty acids on arrhythmias induced by lysophosphatidylcholine or palmitoylcarnitine in neonatal rat cardiac myocytes

1996 • 118 citations

Prevention and Termination of β-Adrenergic Agonist-Induced Arrhythmias by Free Polyunsaturated Fatty Acids in Neonatal Rat Cardiac Myocytes

1995 • 102 citations

Influence of dietary n-3 fatty acids on myocardial ischemia and reperfusion

1990 • 96 citations

cis‐Fatty acids, which activate protein kinase C, attenuate Na+ and Ca2+ currents in mouse neuroblastoma cells.

1989 • 95 citations

Modulation of voltage-dependent Ca channel current by arachidonic acid and other long-chain fatty acids in rabbit intestinal smooth muscle.

1992 • 95 citations

Class I and IV antiarrhythmic drugs and cytosolic calcium regulate mRNA encoding the sodium channel alpha subunit in rat cardiac muscle.

1992 • 74 citations

Polyunsaturated fatty acids exert antiarrhythmic actions as free acids rather than in phospholipids

1996 • 72 citations

EFFECT OF FATTY ACIDS ON THE VENTRICULAR ARRHYTHMIA THRESHOLD IN THE ISOLATED HEART OF THE RABBIT

1981 • 65 citations

THE ROLE OF MYOCARDIAL MEMBRANE LIPIDS IN THE DEVELOPMENT OF CARDIAC NECROSIS

1976 • 59 citations

Structural requirements for charged lipid molecules to directly increase or suppress K+ channel activity in smooth muscle cells. Effects of fatty acids, lysophosphatidate, acyl coenzyme A and sphingosine.

1994 • 56 citations

Long-chain fatty acid-binding to albumin: re-evaluation with directly measured concentrations

1994 • 41 citations

A receptor for type I antiarrhythmic drugs associated with rat cardiac sodium channels.

1987 • 40 citations

Upregulation of the rat cardiac sodium channel by in vivo treatment with a class I antiarrhythmic drug.

1991 • 39 citations

Modulation of neuronal calcium channels by arachidonic acid and related substances

1995 • 37 citations

Modification of K+ channel properties induced by fatty acids in neuroblastoma cells

1991 • 31 citations

Protective Effects of All-Trans-Retinoic Acid Against Cardiac Arrhythmias Induced by Isoproterenol, Lysophosphatidylcholine or Ischemia and Reperfusion

1995 • 28 citations

Effects of arachidonic acid and the other long-chain fatty acids on the membrane currents in the squid giant axon

1988 • 27 citations