Pools of lipidated HTL-CTL constructs prime for multiple HBV and HCV CTL epitope responses

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Solid phase peptide synthesis; a practical approach

1991 • 772 citations

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

1989 • 706 citations

Solid Phase Peptide Synthesis — A Practical Approach

1990 • 680 citations

In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine

1989 • 632 citations

Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives

1991 • 611 citations

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues.

1996 • 566 citations

Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides

1994 • 516 citations

Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs

1990 • 479 citations

Biodegradable microspheres as a vaccine delivery system

1991 • 394 citations

Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides.

1995 • 387 citations

Structure of Peptides Associated with Class I and Class II MHC Molecules

1994 • 381 citations

HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection.

1993 • 333 citations

Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans.

1995 • 332 citations

ESCAPE OF HUMAN IMMUNODEFICIENCY VIRUS FROM IMMUNE CONTROL

1997 • 331 citations

Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex.

1991 • 330 citations

Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.

1995 • 322 citations

Biodegradable microspheres as controlled-release tetanus toxoid delivery systems

1994 • 312 citations

Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection

1997 • 306 citations

Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line.

1989 • 305 citations

HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen.

1991 • 302 citations

Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection.

1996 • 299 citations

Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs

1996 • 263 citations

Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes.

1996 • 259 citations

Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-, interferon gamma-, and nitric oxide-dependent immunity.

1996 • 257 citations

HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.

1993 • 224 citations

Antitumor Activity and Immune Responses Induced by a Recombinant Carcinoembryonic Antigen-Vaccinia Virus Vaccine

1992 • 212 citations

Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes.

1996 • 201 citations

Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules

1996 • 201 citations

Several HLA alleles share overlapping peptide specificities.

1995 • 197 citations

Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.

1996 • 189 citations

Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells.

1997 • 188 citations

Degenerate Cytotoxic T Cell Epitopes from P. falciparum Restricted by Multiple HLA-A and HLA-B Supertype Alleles

1997 • 186 citations

Peptide-based, but not whole protein, vaccines elicit immunity to HER-2/neu, oncogenic self-protein.

1996 • 185 citations

A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge

1993 • 176 citations

Oral administration of an antigenic synthetic lipopeptide (MAP-P3C) evokes salivary antibodies and systemic humoral and cellular responses

1994 • 159 citations

An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans

1994 • 152 citations

Species-restricted interactions between CD8 and the alpha 3 domain of class I influence the magnitude of the xenogeneic response.

1989 • 147 citations

Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implications for vaccine design.

1995 • 142 citations

The hepatitis B virus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection.

1997 • 137 citations

In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes.

1992 • 133 citations

Immunodominance analysis of CTL responses to influenza PR8 virus reveals two new dominant and subdominant Kb-restricted epitopes.

1996 • 128 citations

Lipopeptide immunization without adjuvant induces potent and long‐lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees

1997 • 124 citations

Recombinant polyepitope vaccines for the delivery of multiple CD8 cytotoxic T cell epitopes.

1996 • 123 citations

Differences and similarities in the A2.1‐restricted cytotoxic T cell repertoire in humans and human leukocyte antigen‐transgenic mice

1996 • 119 citations

Specificity and degeneracy in peptide binding to HLA-B7-like class I molecules.

1996 • 103 citations

Overlap in the repertoires of peptides bound in vivo by a group of related class I HLA-B allotypes

1995 • 92 citations

Polymorphism in the alpha 1 helix of the HLA-B heavy chain can have an overriding influence on peptide-binding specificity.

1997 • 91 citations

Protection against lethal viral infection by vaccination with nonimmunodominant peptides.

1996 • 87 citations

Binding and presentation of peptides derived from melanoma antigens MART-1 and glycoprotein-100 by HLA-A2 subtypes. Implications for peptide-based immunotherapy.

1996 • 80 citations

Expression of the mage gene family in primary and metastatic human breast cancer: Implications for tumor antigen‐specific immunotherapy

1995 • 78 citations

Hybrid human immunodeficiency virus Gag particles as an antigen carrier system: induction of cytotoxic T-cell and humoral responses by a Gag:V3 fusion

1993 • 76 citations

Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes.

1997 • 73 citations

Comparison of cytotoxic T lymphocyte responses induced by peptide or DNA immunization: Implications on immunogenicity and immunodominance

1997 • 63 citations

Immunization of human HIV-seronegative volunteers with recombinant p17/p24:Ty virus-like particles elicits HIV-1 p24-specific cellular and humoral immune responses.

1993 • 60 citations

Comparative efficiency of simple lipopeptide constructs for in vivo induction of virus-specific CTL

1996 • 56 citations

Multiple HLA-A alleles can present an immunodominant peptide of the human melanoma antigen Melan-A/MART-1 to a peptide-specific HLA-A*0201+ cytotoxic T cell line.

1996 • 53 citations

Efficacy of synthetic vaccines in the induction of cytotoxic T lymphocytes comparison of the costimulating support provided by helper T cells and lipoamino acid

1994 • 51 citations

Immunization of human HIV-seronegative volunteers with recombinant p17/p24

1993 • 49 citations

Use of Intrinsic and Extrinsic Helper Epitopes for In Vivo Induction of Anti-Hepatitis C Virus Cytotoxic T Lymphocytes (CTL) with CTL Epitope Peptide Vaccines

1996 • 47 citations

Multiple HLA-A alleles can present an immunodominant peptide of the human melanoma antigen Melan-A/MART-1 to a peptide-specific HLA-A*0201+ cytotoxic T cell line.

1996 • 40 citations

Priming for virus-specific CD8+ but not CD4+ cytotoxic T lymphocytes with synthetic lipopeptide is influenced by acylation units and liposome encapsulation

1995 • 36 citations

Protection of mice from Bordetella pertussis respiratory infection using microencapsulated pertussis fimbriae

1995 • 36 citations

Influence of strong CD4 epitope on long-term virus-specific cytotoxic T cell responses induced in vivo with peptides

1996 • 32 citations

Effect of a lipopeptidic formulation on macrophage activation and peptide presentation to T cells

1994 • 23 citations