Prostaglandins in primate semen: biasing the immune system to benefit spermatozoa and virus?

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Innate immunity: impact on the adaptive immune response

1997 • 1,542 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

The production of cytokines by polymorphonuclear neutrophils

1995 • 918 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell.

1977 • 797 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 • 752 citations

Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques.

1996 • 705 citations

Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.

1995 • 676 citations

Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus

1996 • 564 citations

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10

1992 • 516 citations

IL-10 inhibits human T cell proliferation and IL-2 production.

1992 • 491 citations

On the specific vaso‐dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin)

1936 • 452 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

Prostaglandin E inhibits the production of human interleukin 2.

1982 • 423 citations

Inhibition of murine natural killer cell activity by prostaglandins.

1980 • 418 citations

Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2.

1994 • 374 citations

Association of pregnancy-induced hypertension with duration of sexual cohabitation before conception

1994 • 354 citations

The role of natural killer cells in innate resistance to infection

1993 • 330 citations

Immunoregulation by interleukin-12

1996 • 298 citations

To kill or to cure: options in host defense against viral infection

1996 • 268 citations

A possible role of prostaglandins in the inhibition of natural and antibody-dependent cell-mediated cytotoxicity against tumor cells

1978 • 245 citations

Immunology of semen

1987 • 217 citations

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.

1992 • 198 citations

Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors.

1995 • 190 citations

The mechanism of inhibition of human IL 2 production.

1982 • 189 citations

Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production.

1994 • 187 citations

IL-12 synthesis by human Langerhans cells.

1996 • 186 citations

Immunosuppression by seminal plasma and its possible clinical significance

1984 • 174 citations

Extracellular organelles (prostasomes) are immunosuppressive components of human semen

1991 • 154 citations

Immunosuppressive activity of human seminal plasma. I. Inhibition of in vitro lymphocyte activation.

1977 • 152 citations

Effects of TH1 and TH2 cytokines on CD8+ cell response against human immunodeficiency virus: implications for long-term survival.

1995 • 139 citations

IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo.

1995 • 139 citations

Contraception: Immunosuppressive mechanisms in semen: implications for contraception

1995 • 138 citations

19-HydroxyIated E prostaglandins as the major prostaglandins of human semen

1974 • 135 citations

Immunosuppressive Activity of Human Seminal Plasma

1977 • 119 citations

Suppressive effect of seminal plasma on lymphocyte activation

1975 • 114 citations

Accessory cell-derived IL-12 and prostaglandin E2 determine the IFN-gamma level of activated human CD4+ T cells.

1996 • 104 citations

Differential Regulation of the Stability of Cytokine mRNAs in Lipopolysaccharide-activated Blood Monocytes in Response to Interleukin-10

1996 • 99 citations

Cytokine expression by human peripheral blood dendritic cells stimulated in vitro with HIV-1 and herpes simplex virus.

1996 • 94 citations

Cyclic AMP directly inhibits IL-2 receptor expression in human T cells: expression of both p55 and p75 subunits is affected.

1991 • 87 citations

Inhibition of In Vitro Immune Responses by a Fraction from Seminal Plasma

1976 • 82 citations

The modulation of human natural killer cell activity by prostaglandins.

1982 • 80 citations

Prostaglandins in Human Seminal Fluid: Two Novel Compounds

1975 • 80 citations

19-Hydroxyprostaglandin E1 as a major component of the semen of primates

1976 • 72 citations

Transforming Growth Factor β as an Immunosuppressive Protein in Human Seminal Plasma

1993 • 67 citations

Suppression of natural killer cell activity by human seminal plasma in vitro: identification of 19-OH-PGE as the suppressor factor.

1986 • 64 citations

A cytokine switch induced by human seminal plasma: an immune modulation with implications for sexually transmitted disease

1997 • 62 citations

Human cytomegalovirus-induced immunosuppression. Relationship to tumor necrosis factor-dependent release of arachidonic acid and prostaglandin E2 in human monocytes.

1996 • 58 citations

Immunosuppression by seminal prostaglandins.

1989 • 58 citations

Prostaglandin mediated modulation of transforming growth factor-β metabolism in primary mouse osteoblastic cells in vitro

1996 • 55 citations

IL-12 at the Crossroads

1995 • 52 citations

Migration of Foreign Lymphocytes from the Mouse Vagina into the Cervicovaginal Mucosa and to the Iliac Lymph Nodes1

1997 • 43 citations

Human seminal plasma is a potent inhibitor of natural killer cell activity in vitro

1985 • 43 citations

The identification of factors in seminal plasma responsible for suppression of natural killer cell activity.

1988 • 38 citations

Dictionary of Cytokines

1994 • 38 citations

Diploid Expression of Human Leukocyte Antigen Class I and Class II Molecules on Spermatozoa and their Cyclic Inverse Correlation with Inhibin Concentration1

1996 • 36 citations

Materno-fetal immunobiology in normal pregnancy and its possible failure in recurrent spontaneous abortion?

1995 • 33 citations

Prostaglandin E2 promotes the induction of anergy during T helper cell recognition of myelin basic protein

1995 • 33 citations

Suppression of natural and activated human antitumour cytotoxicity by human seminal plasma.

1986 • 30 citations

Delineation Between T and B Suppressive Molecules From Human Seminal Plasma: II. Spermine is the Major Suppressor of T‐Lymphocytes in Vitro

1990 • 28 citations

SIGNAL TRANSDUCTION IN Th CLONES: TARGET OF DIFFERENTIAL MODULATION BY PGE2MAY RESIDE DOWNSTREAM OF THE PKC-DEPENDENT PATHWAY

1996 • 28 citations

THE IMMUNOSUPPRESSIVE PROPERTIES OF NEW ORAL PROSTAGLANDIN E1 ANALOGS

1990 • 24 citations

Regulation by prostaglandin E2 of interleukin release by T lymphocytes in mucosa

1996 • 21 citations

Some Aspects of Prostaglandins in Reproduction

1974 • 17 citations