Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

1992 • 897 citations

The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein

1989 • 680 citations

ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

1994 • 498 citations

Quantitative analysis of total macrophage content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80.

1985 • 413 citations

Direct Evidence for a Bone Marrow Origin of the Alveolar Macrophage in Man

1976 • 381 citations

Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.

1991 • 334 citations

Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E.

1981 • 302 citations

Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes.

1982 • 296 citations

Bone Marrow Origin of Hepatic Macrophages (Kupffer Cells) in Humans

1978 • 226 citations

Origin and kinetics of monocytes and macrophages.

1970 • 223 citations

Origin and Turnover of Monocytes and Macrophages

1989 • 200 citations

Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages

1985 • 200 citations

HEMATOPOIETIC ORIGIN OF MACROPHAGES AS STUDIED BY CHROMOSOME MARKERS IN MICE

1968 • 185 citations

Extrahepatic synthesis of apolipoprotein E.

1984 • 177 citations

Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteins.

1985 • 163 citations

THE ORIGIN OF ALVEOLAR MACROPHAGES IN MOUSE RADIATION CHIMERAS

1972 • 145 citations

Formation of cholesterol- and apoprotein E-enriched high density lipoproteins in vitro.

1983 • 142 citations

Immunoreactive apolipoprotein E is a widely distributed cellular protein. Immunohistochemical localization of apolipoprotein E in baboon tissues.

1986 • 116 citations

Apolipoprotein E synthesis in peripheral tissues of nonhuman primates.

1985 • 106 citations

Pathways in the development of liver macrophages: alternative precursors contained in populations of lymphocytes and bone-marrow cells

1968 • 71 citations

Role of Heparan Sulfate Proteoglycans and the LDL Receptor‐Related Protein in Remnant Lipoprotein Metabolisma

1994 • 68 citations

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

1992 • 54 citations

Quantification and regulation of apolipoprotein E expression in rat Kupffer cells.

1989 • 42 citations

Studies on the distribution of macrophages derived from rat bone marrow cells in xenogeneic radiation chimaeras.

1972 • 35 citations

Cellular interactions in marrow-grafted patients. II. Normal monocyte antigen-presenting and defective T-cell-proliferative functions early after grafting and during chronic graft-versus-host disease.

1984 • 25 citations

FURTHER STUDIES ON THE TRANSFORMATION OF THORACIC DUCT CELLS INTO LIVER MACROPHAGES

1966 • 21 citations

Cholesterol, Apolipoprotein E, and Immune Cell Function

2020 • 3 citations