S-Nitrosohemoglobin Is Unstable in the Reductive Erythrocyte Environment and Lacks O2/NO-linked Allosteric Function

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Oxidized Redox State of Glutathione in the Endoplasmic Reticulum

1992 • 1,909 citations

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

1996 • 1,604 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation

1998 • 1,162 citations

Blood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient

1997 • 1,050 citations

Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways.

1993 • 616 citations

Export by red blood cells of nitric oxide bioactivity

2001 • 579 citations

Reactions between nitric oxide and haemoglobin under physiological conditions

1998 • 577 citations

Role of circulating nitrite and S -nitrosohemoglobin in the regulation of regional blood flow in humans

2000 • 445 citations

Thrombin Activates the Hypoxia-Inducible Factor-1 Signaling Pathway in Vascular Smooth Muscle Cells

2001 • 415 citations

[26] Oxidative reactions of hemoglobin

1990 • 397 citations

S-Nitrosothiols signal the ventilatory response to hypoxia

2001 • 322 citations

Characterization of the Magnitude and Kinetics of Xanthine Oxidase-catalyzed Nitrite Reduction

2001 • 270 citations

Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery

2001 • 267 citations

Relative role of heme nitrosylation and β-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation

2000 • 257 citations

Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery

2001 • 229 citations

Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease

2002 • 227 citations

Allosteric Effects in Haemoglobin

1982 • 205 citations

A chemiluminescense-based assay for S-nitrosoalbumin and other plasma S-nitrosothiols

2000 • 181 citations

Modulation of nitric oxide bioavailability by erythrocytes

2001 • 175 citations

An autocatalytic mechanism of protein nitrosylation

2000 • 141 citations

Functional Coupling of Oxygen Binding and Vasoactivity inS-Nitrosohemoglobin

2000 • 141 citations

Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial ?-arginine–NO pathway

1999 • 138 citations

Biochemical Characterization of HumanS-Nitrosohemoglobin

1999 • 135 citations

Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity

1999 • 132 citations

Reductive Assays forS-Nitrosothiols: Implications for Measurements in Biological Systems

1998 • 127 citations

Development of Chemiluminescence-Based Methods for Specific Quantitation of Nitrosylated Thiols

1998 • 127 citations

Biochemical Characterization ofS-Nitrosohemoglobin

1999 • 118 citations

Covalent binding of glutathione to hemoglobin. I. Inhibition of hemoglobin S polymerization.

1986 • 101 citations

S-Nitrosothiol Formation in Blood of Lipopolysaccharide-Treated Rats

2000 • 82 citations

[11] Concerted nitric oxide/oxygen delivery by hemoglobin

1999 • 76 citations

S-Nitrosohemoglobin in the Fetal Circulation May Represent a Cycle for Blood Pressure Regulation

1997 • 73 citations

Specific S-nitrosothiol (thionitrite) quantification as solution nitrite after vanadium(III) reduction and ozone-chemiluminescent detection

1998 • 67 citations

Effects of S-Nitrosation on Oxygen Binding by Normal and Sickle Cell Hemoglobin

1999 • 66 citations

[18] Measurement of glutathione redox state in cytosol and secretory pathway of cultured cells

1995 • 55 citations

A Mutagenic Study of the Allosteric Linkage of His(HC3)146β in Haemoglobin

1993 • 46 citations

Crystallographic analysis of mutant human haemoglobins made in Escherichia coli

1986 • 41 citations

Effects of S-Nitrosation of Hemoglobin on Hypoxic Pulmonary Vasoconstriction and Nitric Oxide Flux

2001 • 28 citations

Inhibition of erythrocyte sickling by thiol reagents.

1984 • 24 citations

Structure-Function Relationships in Hemoglobin Kariya, Lys-40(C5)α → Glu, with High Oxygen Affinity

1989 • 16 citations

Hemoglobin roanne [α94(G1) asp å glu]: a variant of the α1β2 interface with an unexpected high oxygen affinity

1995 • 13 citations

The Heme–Globin and Dimerization Equilibria of Recombinant Human Hemoglobins Carrying Site-Specific β Chains Mutations

2001 • 4 citations