The Fos family of transcription factors and their role in tumourigenesis

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

AP-1 in cell proliferation and survival

2001 • 1,686 citations

Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis

2003 • 1,535 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

Target genes of β-catenin–T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas

1999 • 807 citations

AP-1 in mouse development and tumorigenesis

2001 • 727 citations

Induction of proto-oncogene JUN/AP-1 by serum and TPA

1988 • 689 citations

c-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene

1984 • 601 citations

c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins.

1991 • 543 citations

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

1989 • 488 citations

Fra-1 replaces c-Fos-dependent functions in mice

2000 • 464 citations

Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis

2001 • 455 citations

Function and regulation of AP-1 subunits in skin physiology and pathology

2001 • 396 citations

ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility

2003 • 389 citations

Molecular Pathogenesis of Cancer of the Cervix and Its Causation by Specific Human Papillomavirus Types

1994 • 381 citations

c-fos is required for malignant progression of skin tumors

1995 • 353 citations

Osteoblasts are target cells for transformation in c-fos transgenic mice

1993 • 347 citations

Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells.

2001 • 304 citations

Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental carcinogen in male F344 rat liver.

1994 • 291 citations

Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved.

1999 • 264 citations

Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation

2002 • 259 citations

Helicobacter pylori Activates Mitogen-activated Protein Kinase Cascades and Induces Expression of the Proto-oncogenes c-fos and c-jun

2000 • 251 citations

Molecular Profiling of Inflammatory Breast Cancer

2004 • 230 citations

Constitutive activation of transcription factors NF-?B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines

1999 • 221 citations

Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin

2004 • 214 citations

FRA-1 expression level regulates proliferation and invasiveness of breast cancer cells

2004 • 212 citations

Fra-1 Induces Morphological Transformation and Increases In Vitro Invasiveness and Motility of Epithelioid Adenocarcinoma Cells

1998 • 187 citations

Prognostic value of ERBB-1, VEGF, cyclin A, FOS, JUN and MYC in patients with squamous cell lung carcinomas

1998 • 183 citations

<i>C-myc</i> and <i>c-fos</i> in Human Osteosarcoma: Prognostic Value of mRNA and Protein Expression

1998 • 178 citations

A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras.

1991 • 172 citations

Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer.

2003 • 171 citations

Fos family members: regulation, structure and role in oncogenic transformation.

2000 • 162 citations

Identification of differentially expressed genes in esophageal squamous cell carcinoma (ESCC) by cDNA expression array: overexpression of Fra-1, Neogenin, Id-1, and CDC25B genes in ESCC.

2001 • 159 citations

Role and regulation of activator protein-1 in toxicant-induced responses of the lung

2002 • 149 citations

Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product

1997 • 142 citations

Expression of c-Myc, c-Fos, and c-Jun in hepatocellular carcinoma

2001 • 140 citations

Regulation of Fra-1 and Fra-2 phosphorylation differs during the cell cycle of fibroblasts and phosphorylation in vitro by MAP kinase affects DNA binding activity.

1994 • 137 citations

The Role of the AP-1 Transcription Factors c-Fos, FosB, Fra-1 and Fra-2 in the Invasion Process of Mammary Carcinomas

2004 • 124 citations

Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells

2003 • 123 citations

Epidermal growth factor-induced hepatocellular carcinoma: gene expression profiles in precursor lesions, early stage and solitary tumours

2005 • 116 citations

Expression patterns of immediate early transcription factors in human non-small cell lung cancer. The Lung Cancer Study Group.

1995 • 114 citations

The Role of JNK and p38 MAPK Activities in UVA-Induced Signaling Pathways Leading to AP-1 Activation and c-Fos Expression

2003 • 112 citations

Mesothelial cell transformation requires increased AP-1 binding activity and ERK-dependent Fra-1 expression.

2002 • 111 citations

Activation of the JNK–AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas

2003 • 107 citations

Alterations in gene expression and activity during squamous cell carcinoma development.

2002 • 102 citations

Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription

1997 • 100 citations

Expression pattern of the AP-1 family in breast cancer: Association of fosB expression with a well-differentiated, receptor-positive tumor phenotype

1999 • 97 citations

Differential gene expression in nasopharyngeal carcinoma cells

2000 • 96 citations

Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma.

2003 • 95 citations

Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-α mediated repression of viral transcription and modification of the AP-1 transcription complex

1999 • 90 citations

Favorable clinical outcome of cervical cancers infected with human papilloma virus type 58 and related types

1999 • 88 citations

High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model

2000 • 87 citations

Transformation by Fos proteins requires a C-terminal transactivation domain.

1993 • 82 citations

Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer

2004 • 82 citations

Requirement of an AP-1 Site in the Calcium Response Region of the Involucrin Promoter

2000 • 81 citations

Ovarian Cancer Cell Proliferation and Motility Is Induced by Engagement of Integrin αvβ3/Vitronectin Interaction

2003 • 80 citations

Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells

2004 • 78 citations

FRA-1 Expression Level Modulates Regulation of Activator Protein-1 Activity by Estradiol in Breast Cancer Cells

1998 • 77 citations

The role of c‐Jun and c‐Fos expression in androgen‐independent prostate cancer

2004 • 76 citations

The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesis

2003 • 75 citations

Accelerated Cell Cycle Progression in Osteoblasts Overexpressing the c-fos Proto-oncogene

2004 • 74 citations

Progesterone Receptor Isoforms, PR-B and PR-A, in Breast Cancer: Correlations with Clinicopathologic Tumor Parameters and Expression of AP-1 Factors

2000 • 74 citations

Immunohistochemical detection of c-fos and c-jun expression in osseous and cartilaginous tumours of the skeleton

1998 • 74 citations

Transcription factor Fos-related antigen 1 is an effective target for a breast cancer vaccine

2003 • 73 citations

Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators

2001 • 73 citations

Elevated protein expression of cyclin D1 and Fra‐1 but decreased expression of c‐Myc in human colorectal adenocarcinomas overexpressing β‐catenin

2002 • 72 citations

Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts

2004 • 71 citations

Expression of cell cycle-regulatory proteins Rb, p16/MTS1, p27/KIP1, p21/WAF1, cyclin D1 and cyclin E in breast cancer: Correlations with expression of activating protein-1 family members

2000 • 69 citations

Matrix Metalloproteinase/Epidermal Growth Factor Receptor/Mitogen-Activated Protein Kinase Signaling Regulate fra-1 Induction by Cigarette Smoke in Lung Epithelial Cells

2004 • 65 citations

Role of the Fos family members, c-Fos, Fra-1 and Fra-2, in the regulation of cell motility

2003 • 65 citations

Extracellular Signal-regulated Kinase 1/2-mediated Phosphorylation of JunD and FosB Is Required for Okadaic Acid-induced Activator Protein 1 Activation

1999 • 65 citations

Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals

1993 • 60 citations

Constitutive Expression of the AP-1 Transcription Factors c-jun, junD, junB, and c-fos and the Marginal Zone B-Cell Transcription Factor Notch2 in Splenic Marginal Zone Lymphoma

2004 • 57 citations

Transition from SCLC to NSCLC phenotype is accompanied by an increased TRE-binding activity and recruitment of specific AP-1 proteins

1998 • 56 citations

Expression profile of genes in non-small cell lung carcinomas from long-term surviving patients.

2002 • 56 citations

Immunolocalization of c‐Fos and c‐Jun in human oral mucosa and in oral squamous cell carcinoma

2002 • 54 citations

Control of cell cycle gene expression in bone development and during c-Fos-induced osteosarcoma formation

1998 • 54 citations

FRA-1 expression in hyperplastic and neoplastic thyroid diseases.

2000 • 51 citations

Overexpression of oncoproteins in non-small cell lung carcinomas of smokers

1993 • 51 citations

Gene Expression Screening of Salivary Gland Neoplasms

2004 • 49 citations

Association of human papillomavirus infection with carcinoma of the cervix uteri and its precursor lesions: theoretical and practical implications

2000 • 48 citations

FosB is Highly Expressed in Normal Mammary Epithelia, but Down-Regulated in Poorly Differentiated Breast Carcinomas

2003 • 48 citations

Alterations in Activating Protein 1 Composition Correlate with Phenotypic Differentiation Changes Induced by Resveratrol in Human Melanoma

2004 • 44 citations

Adenoviral delivery of A-FOS, an AP-1 dominant negative, selectively inhibits drug resistance in two human cancer cell lines

2002 • 43 citations

Alterations in gene expression and activity during squamous cell carcinoma development

2002 • 43 citations

Genetic complementation to non-tumorigenicity in cervical-carcinoma cells correlates with alterations in AP-1 composition

2000 • 42 citations

Dual role for mitogen-activated protein kinase (Erk) in insulin-dependent regulation of Fra-1 (fos-related antigen-1) transcription and phosphorylation

2002 • 40 citations

The ability of Fos family members to produce phenotypic changes in epithelioid cells is not directly linked to their transactivation potentials

2002 • 39 citations

Expression of Egr-1, c-fos and cyclin D1 in esophageal cancer and its precursors: An immunohistochemical andin situhybridization study

2004 • 36 citations

Identification of rat pancreatic carcinoma genes associated with lymphogenous metastasis.

2002 • 35 citations

Identification of DNA copy number changes in microdissected serous ovarian cancer tissue using a cDNA microarray platform

2004 • 35 citations

Differential expression of c‐jun and c‐fos mRNAs in squamous cell carcinoma of the head and neck: Associations with uPA, gelatinase B, and matrilysin mRNAs

2001 • 34 citations

Influence of the proto-oncogene c-fos on cisplatin sensitivity

2000 • 34 citations

During Human Melanoma Progression AP‐1 Binding Pairs are Altered with Loss of c‐Jun In Vitro

2004 • 32 citations

Value of GlutathioneS-Transferase π and the Oncogene Products c-Jun, c-Fos, c-H-Ras, and c-Myc as a Prognostic Indicator in Endometrial Carcinomas

1998 • 29 citations

Overexpression ofc-Ki-ras andc-fos in human pancreatic carcinomas

1992 • 26 citations

Detection of c‐fos expression in benign and malignant musculoskeletal lesions

2001 • 25 citations

FRA-1 Expression Level Modulates Regulation of Activator Protein-1 Activity by Estradiol in Breast Cancer Cells

1998 • 23 citations

Clinical implication of fos and jun expressions and protein kinase activity in endometrial cancers.

1995 • 20 citations

Immunohistochemical localisation of the c-fos oncoprotein in pancreatic cancers.

1994 • 19 citations

Expression of fos and jun Proto-oncogenes in Benign versus Malignant Human Uterine Tissue

2000 • 18 citations

Screening of Specific Changes in mRNAS in Thyroid Tumors by Sequence Specific Differential Display. Decreased Expression of c-fos mRNA in Papillary Carcinoma.

1999 • 17 citations

Fra-1 Expression in Malignant and Benign Thyroid Tumor

2001 • 14 citations

The Association between <i>c-fos</i> and <i>c-jun</i> Expression and Estrogen and Progesterone Receptors Is Lost in Human Endometrial Cancer

1999 • 10 citations

Correlation between successful heterotransplantation of lung tumors in nude mice, poor prognosis of patients and expression of Fos, Jun, ErbB1, and Ras.

1993 • 6 citations

Signal transduction pathway of the induction of cell motility in hamster pancreatic ductal adenocarcinoma cell.

1997 • 6 citations

Chemical carcinogenesis is accelerated in c-fos transgenic mice.

1990 • 6 citations