Reading between the lines: SH3 recognition of an intact protein

Protein modules and signalling networks

1995 • 2,447 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC

1992 • 670 citations

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

1995 • 557 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1994 • 519 citations

Crystal Structure of the Conserved Core of HIV-1 Nef Complexed with a Src Family SH3 Domain

1996 • 433 citations

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

1995 • 349 citations

The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

1996 • 336 citations

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

1994 • 310 citations

HIV accessory proteins: Leading roles for the supporting cast

1995 • 283 citations

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.

1995 • 256 citations

Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries.

1994 • 256 citations

Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk

1995 • 243 citations

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

1996 • 193 citations

Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries.

1994 • 166 citations

Characterization of the Interaction of Natural Proline-Rich Peptides with Five Different SH3 Domains

1994 • 131 citations

NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos

1994 • 104 citations

Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos

1994 • 97 citations

Orientation of Peptide Fragments from Sos Proteins Bound to the N-Terminal SH3 Domain of Grb2 Determined by NMR Spectroscopy

1994 • 80 citations

The Ffynnon Beuno and Cae Gwyn Caves

1887 • 1 citations