Pontine cholinergic mechanisms and their impact on respiratory regulation

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1982 • 53,055 citations

Principles and Practice of Sleep Medicine

2011 • 5,079 citations

Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)

1983 • 2,305 citations

Histochemical mapping of nitric oxide synthase in the rat brain

1992 • 1,858 citations

Principles and practice of sleep medicine

1995 • 1,389 citations

Muscarinic Receptors—Characterization, coupling and function

1993 • 1,264 citations

Distribution of cholinergic neurons in rat brain: Demonstrated by the immunocytochemical localization of choline acetyltransferase

1983 • 964 citations

Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat

1990 • 952 citations

Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies

1991 • 903 citations

Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems

1990 • 779 citations

Synaptic Control of Motoneuronal Excitability

2000 • 586 citations

Afferent connections of the laterodorsal and the pedunculopontine tegmental nuclei in the rat: A retro‐ and antero‐grade transport and immunohistochemical study

1992 • 535 citations

Localization of a family of muscarinic receptor mRNAs in rat brain

1988 • 472 citations

The Anesthetic Mechanism of Urethane: The Effects on Neurotransmitter-Gated Ion Channels

2002 • 444 citations

Medullary and spinal efferents of the pedunculopontine tegmental nucleus and adjacent mesopontine tegmentum in the rat

1988 • 423 citations

Paradoxical sleep and its chemical/structural substrates in the brain

1991 • 402 citations

The diversity of subunit composition in nAChRs: Evolutionary origins, physiologic and pharmacologic consequences

2002 • 401 citations

Suitability of urethane anesthesia for physiopharmacological investigations in various systems Part 1: General considerations

1986 • 389 citations

Mapping of cholinoceptive brainstem structures responsible for the generation of paradoxical sleep in the cat.

1989 • 380 citations

Unitary characteristics of presumptive cholinergic tegmental neurons during the sleep-waking cycle in freely moving cats

1989 • 358 citations

The rat ponto‐medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study

2002 • 342 citations

Contributions of the Pedunculopontine Region to Normal and Altered REM Sleep

1997 • 299 citations

The Anesthetic Mechanism of Urethane: The Effects on Neurotransmitter-Gated Ion Channels

2002 • 296 citations

Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat

1994 • 292 citations

Distribution of acetylcholine and catecholamine neurons in the cat brainstem: A choline acetyltransferase and tyrosine hydroxylase immunohistochemical study

1987 • 284 citations

Motoneuron properties during motor inhibition produced by microinjection of carbachol into the pontine reticular formation of the decerebrate cat

1987 • 277 citations

Afferent projections to the cholinergic pedunculopontine tegmental nucleus and adjacent midbrain extrapyramidal area in the albino rat. I. Retrograde tracing studies

1992 • 273 citations

Serotonergic and cholinergic inhibition of mesopontine cholinergic neurons controlling rem sleep: An in vitro electrophysiological study

1994 • 271 citations

Neuronal activity specific to paradoxical sleep in the ventromedial medullary reticular formation of unrestrained cats

1980 • 245 citations

Firing of ‘possibly’ cholinergic neurons in the rat laterodorsal tegmental nucleus during sleep and wakefulness

1992 • 242 citations

Bulbo-thalamic neurons related to thalamocortical activation processes during paradoxical sleep

1984 • 237 citations

The pedunculopontine nucleus—Auditory input, arousal and pathophysiology

1995 • 231 citations

Discharge Profiles of Juxtacellularly Labeled and Immunohistochemically Identified GABAergic Basal Forebrain Neurons Recorded in Association with the Electroencephalogram in Anesthetized Rats

2000 • 226 citations

Serotonin hyperpolarizes cholinergic low-threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro.

1992 • 224 citations

Nitric oxide synthase immunoreactivity in rat pontine medullary neurons

1994 • 196 citations

State-dependent release of acetylcholine in rat thalamus measured by in vivo microdialysis

1994 • 194 citations

Behavioral State Control through Differential Serotonergic Inhibition in the Mesopontine Cholinergic Nuclei: A Simultaneous Unit Recording and Microdialysis Study

1998 • 193 citations

Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 2: Cardiovascular system

1986 • 192 citations

Neuronal nicotinic receptors: from protein structure to function

2001 • 186 citations

Maturation of the Mammalian Respiratory System

1999 • 186 citations

Modulation of respiratory activity of neonatal rat phrenic motoneurones by serotonin.

1993 • 176 citations

Enhancement of acetylcholine release during paradoxical sleep in the dorsal tegmental field of the cat brain stem

1990 • 175 citations

Discharge Properties of Juxtacellularly Labeled and Immunohistochemically Identified Cholinergic Basal Forebrain Neurons Recorded in Association with the Electroencephalogram in Anesthetized Rats

2000 • 163 citations

Induction of rapid eye movement sleep by carbachol infusion into the pontine reticular formation in the rat

1995 • 157 citations

Principles and Practice of Sleep Medicine, 2nd ed

1995 • 151 citations

Brainstem sites for the carbachol elicitation of the hippocampal theta rhythm in the rat

1993 • 150 citations

Presynaptic depression of excitatory synaptic inputs to rat hypoglossal motoneurons by muscarinic M2 receptors

1996 • 146 citations

Localization of pontine PGO wave generation sites and their anatomical projections in the rat

1998 • 144 citations

Neuropharmacology of control of respiratory rhythm and pattern in mature mammals

2000 • 143 citations

Distribution of choline acetyltransferase immunopositive structures in the rat brainstem

1989 • 141 citations

Cholinergic neurons in the rat central nervous system demonstrated by in situ hybridization of choline acetyltransferase mRNA

1992 • 139 citations

Possible modulation of the medullary respiratory rhythm generator by the noradrenergic A5 area: an in vitro study in the newborn rat

1989 • 137 citations

Catecholaminergic depressant effects on bulbar respiratory mechanisms

1979 • 137 citations

Localization of pontine PGO wave generation sites and their anatomical projections in the rat

1998 • 133 citations

Brainstem neuromodulation and REM sleep

1995 • 133 citations

A cholinoceptive desynchronized sleep induction zone in the anterodorsal pontine tegmentum: Locus of the sensitive region

1990 • 133 citations

Control of Upper Airway Motoneurons During REM Sleep

1998 • 132 citations

Localization of cardiac vagal preganglionic motoneurones in the rat: Immunocytochemical evidence of synaptic inputs containing 5‐hydroxytryptamine

1993 • 132 citations

Modulation of respiratory rhythm in vitro: role of Gi/o protein-mediated mechanisms

1996 • 129 citations

c-Fos Expression in GABAergic, Serotonergic, and Other Neurons of the Pontomedullary Reticular Formation and Raphe after Paradoxical Sleep Deprivation and Recovery

2000 • 128 citations

Suppression of hypoglossal motoneurons during the carbachol-induced atonia of REM sleep is not caused by fast synaptic inhibition

1993 • 122 citations

Importance of cholinergic, GABAergic, serotonergic and other neurons in the medial medullary reticular formation for sleep-wake states studied by cytotoxic lesions in the cat

1994 • 119 citations

Neuronal activity specific to REM sleep and its relationship to breathing

1977 • 117 citations

Presynaptic inhibition of glutamatergic synaptic transmission to rat motoneurons by serotonin

1996 • 116 citations

Multiplicity of muscarinic autoreceptor subtypes? Comparison of the distribution of cholinergic cells and cells containing mRNA for five subtypes of muscarinic receptors in the rat brain

1994 • 107 citations

Carbachol models of REM sleep: recent developments and new directions.

2001 • 100 citations

The carbachol-induced enhancement of desynchronized sleep signs is dose dependent and antagonized by centrally administered atropine

1989 • 100 citations

Inhibition of carbachol microinjections of presumptive cholinergic PGO-on neurons in freely moving cats

1990 • 99 citations

5‐HT‐1A receptor‐mediated modulation of medullary expiratory neurones in the cat.

1994 • 99 citations

Serotonergic influences on central respiratory activity: an in vitro study in the newborn rat

1990 • 99 citations

Mutual interactions among cholinergic, noradrenergic and serotonergic neurons studied by ionophoresis of these transmitters in rat brainstem nuclei

1993 • 98 citations

Modification of Paradoxical Sleep Following Transections of the Reticular Formation at the Pontomedullary Junction

1986 • 96 citations

Acetylcholine Modulates Respiratory Pattern: Effects Mediated by M3-Like Receptors in PreBötzinger Complex Inspiratory Neurons

2000 • 91 citations

Neurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-cholinergic cell area in the cat. I. Effects upon the cholinergic innervation of the brain

1988 • 83 citations

Permanent release of noradrenaline modulates respiratory frequency in the newborn rat: an in vitro study.

1990 • 82 citations

Distribution of cholinergic, gabaergic and serotonergic neurons in the medial medullary reticular formation and their projections studied by cytotoxic lesions in the cat

1994 • 82 citations

Behaviour of raphe cells projecting to the dorsomedial medulla during carbachol‐induced atonia in the cat.

1996 • 81 citations

A5 cells are silenced when REM sleep-like signs are elicited by pontine carbachol

2002 • 81 citations

Mechanisms Underlying Regulation of Respiratory Pattern by Nicotine in PreBötzinger Complex

2001 • 78 citations

Characterization and quantitative autoradiographic distribution of [3H]acetylcholine muscarinic receptors in mammalian brain. Apparent labelling of an M2-like receptor sub-type

1989 • 77 citations

Interaction of Serotonergic Excitatory Drive to Hypoglossal Motoneurons With Carbachol-Induced, REM Sleep-Like Atonia

1996 • 77 citations

Rapid Eye Movement Sleep induction by microinjection of the GABA-A antagonist bicuculline into the dorsal subcoeruleus area of the rat

2003 • 73 citations

Alterations in blood pressure and REM sleep after pontine carbachol microinfusion

1986 • 72 citations

M2 muscarinic autoreceptors modulate acetylcholine release in the medial pontine reticular formation.

1998 • 71 citations

Excitotoxic lesions of the pedunculopontine tegmental nucleus of the rat. II. Examination of eating and drinking, rotation, and reaching and grasping following unilateral ibotenate or quinolinate lesions

1992 • 68 citations

Sleep Science: Integrating Basic Research and Clinical Practice

1997 • 67 citations

Presence of functional neuronal nicotinic acetylcholine receptors in brainstem motoneurons of the rat

1999 • 66 citations

Raphespinal and reticulospinal axon collaterals to the hypoglossal nucleus in the rat

1992 • 64 citations

Cholinergic stimulation of the pons depresses respiration in decerebrate cats

1990 • 62 citations

Cholinergic Mechanisms Regulating REM Sleep

1997 • 62 citations

Phasic relationship between the activity of basal forebrain neurons and cortical EEG in urethane-anesthetized rat

1997 • 62 citations

Sleep Apnea

2011 • 61 citations

Responses of presumed cholinergic mesopontine tegmental neurons to carbachol microinjections in freely moving cats

1990 • 60 citations

Contribution of cholinergic systems to state-dependent modulation of respiratory control

2002 • 59 citations

Muscarinic receptor subtypes are differentially distributed across brain stem respiratory nuclei

1995 • 57 citations

5‐HT2 receptor‐controlled modulation of medullary respiratory neurones in the cat.

1995 • 56 citations

Descending projections from the dorsolateral pontine tegmentum to the paramedian reticular nucleus of the caudal medulla in the cat

1990 • 56 citations

Pontine carbachol elicits multiple rapid eye movementsleep-like neural events in urethane-anaesthetized rats

1999 • 56 citations

Nicotinic excitation of rat hypoglossal motoneurons

2002 • 55 citations

Postnatal development of serotonin 1B, 2 A and 2C receptors in brainstem motoneurons

2003 • 55 citations

Location and quantification of muscarinic receptor subtypes in rat pons: implications for REM sleep generation

1997 • 54 citations

Selective blockade of different brain stem muscarinic receptor subtypes: effects on the sleep-wake cycle

1994 • 53 citations

Pharmacology of Nicotinic Receptors in PreBötzinger Complex That Mediate Modulation of Respiratory Pattern

2002 • 53 citations

α1B receptors are the main postsynaptic mediators of adrenergic excitation in brainstem motoneurons, a single-cell RT-PCR study

2001 • 52 citations

Brainstem carbachol injections in the urethane anesthetized rat produce hippocampal theta rhythm and cortical desynchronization: a comparison of pedunculopontine tegmental versus nucleus pontis oralis injections

1998 • 50 citations

Behavior of hypoglossal inspiratory premotor neurons during the carbachol-induced, REM sleep-like suppression of upper airway motoneurons

2000 • 49 citations

Carbachol microinjections in the mediodorsal pontine tegmentum are unable to induce paradoxical sleep after caudal pontine and prebulbar transections in the cat

1991 • 48 citations

The Modulation by 5‐HT of Glutamatergic Inputs from the Raphe Pallidus to Rat Hypoglossal Motoneurones, in vitro

2003 • 47 citations

Cholinoceptive properties of respiratory neurones in the rat medulla

1983 • 47 citations

Evocation of postural atonia and respiratory depression by pontine carbachol in the decerebrate rat

1992 • 46 citations

Synaptic activation of hypoglossal respiratory motorneurons during inspiration in rats

2002 • 45 citations

Microelectrophoretic application of putative neurotransmitters onto various types of bulbar respiratory neurons.

1979 • 44 citations

Immunostaining of cholinergic pontomesencephalic neurons for α1 versus α2 adrenergic receptors suggests different sleep–wake state activities and roles

2002 • 43 citations

Central Respiratory Activity in Rapid Eye Movement Sleep: Augmenting and Latin Inspiratory Cells

1994 • 42 citations

Cholinoceptive pontine reticular mechanisms cause state-dependent respiratory changes in the cat

1989 • 41 citations

A GABAergic pontine reticular system is involved in the control of wakefulness and sleep.

1999 • 39 citations

Respiratory pattern modulation by the pedunculopontine tegmental nucleus

2003 • 38 citations

Critical Role for M3Muscarinic Receptors in Paradoxical Sleep Generation in the Cat

1997 • 38 citations

Combined antagonism of aminergic excitatory and amino acid inhibitory receptors in the XII nucleus abolishes REM sleep-like depression of hypoglossal motoneuronal activity.

2004 • 36 citations

Subcellular localization of neuronal nitric oxide synthase in the rat nucleus of the solitary tract in relation to vagal afferent inputs

2003 • 35 citations

Arousal state vs. temperature effects on neuronal activity in subcoeruleus area

1989 • 34 citations

Relative magnitude of tonic and phasic synaptic excitation of medullary inspiratory neurons in dogs

2000 • 33 citations

The effects of acetylcholine on bulbar respiratory related neurones

1984 • 32 citations

Substance P in the descending cholinergic projection to REM sleep‐induction regions of the rat pontine reticular formation: anatomical and electrophysiological analyses

2002 • 31 citations

RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Bötzinger complex

2001 • 29 citations

Cortical activation states in sleep and anesthesia. I: Cardio-respiratory effects

1998 • 27 citations

Behavior of hypoglossal inspiratory premotor neurons during the carbachol-induced, REM sleep-like suppression of upper airway motoneurons

2000 • 27 citations

Effects of iontophoretically applied acetylcholine on membrane potential and synaptic activity of bulbar respiratory neurones in decerebrate cats

1996 • 24 citations

Ventilatory pattern and chemosensitivity in M1 and M3 muscarinic receptor knockout mice

2003 • 24 citations

Inactivation of the Pons Blocks Medullary-induced Muscle Tone Suppression in the Decerebrate Cat

1998 • 24 citations

Behavior of VRG neurons during the atonia of RFM sleep induced by pontine carbachol in decerebrate cats

1992 • 23 citations

Differential suppression of upper airway motor activity during carbachol-induced, REM sleep-like atonia

1998 • 23 citations

Spontaneous Ventilation and Respiratory Motor Output During Carbachol-induced Atonia of REM Sleep in the Decerebrate Cat

1992 • 22 citations

Evidence for a respiration-modulated cholinergic action on the activity of medullary respiration-related neurons in the rabbit

1989 • 19 citations

Comparison of three muscarinic agonists injected into the medial pontine reticular formation of rats to enhance REM sleep

2001 • 16 citations

Hyperoxia increases paradoxical sleep rhythm in the pontine cat

1998 • 13 citations

Chapter 13 Molecular aspects of muscarinic receptor assembly and function

1996 • 13 citations

Power spectral analysis of blood pressure fluctuations during sleep in normal and decerebrate cats.

1994 • 13 citations

Pontine injections of nitric oxide synthase inhibitor l-name consolidate episodes of rem sleep in the rat.

1998 • 12 citations

Pontine cholinergic respiratory depression in neonatal and young rats

1998 • 10 citations

Microelectrophoretic application of antagonists of putative neurotransmitters onto various types of bulbar respiratory neurons.

1979 • 9 citations