Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

1985 • 904 citations

Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate.

1984 • 653 citations

Mechanisms of calcium channel modulation by β-adrenergic agents and dihydropyridine calcium agonists

1986 • 493 citations

Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

1985 • 445 citations

β-Adrenergic modulation of calcium channels in frog ventricular heart cells

1984 • 387 citations

Actions of sympathomimetic amines on the Ca2+ transients and contractions of rabbit myocardium: reciprocal changes in myofibrillar responsiveness to Ca2+ mediated through alpha- and beta-adrenoceptors.

1988 • 337 citations

Diminished inotropic response of aged myocardium to catecholamines.

1975 • 336 citations

Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes.

1990 • 307 citations

A model for early afterdepolarizations: induction with the Ca2+ channel agonist Bay K 8644.

1988 • 244 citations

Beta 1-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2+, and Ca2+ current in single rat ventricular cells.

1993 • 241 citations

Simultaneous measurement of Ca2+, contraction, and potential in cardiac myocytes

1990 • 211 citations

Age-related augmentation of plasma catecholamines during dynamic exercise in healthy males

1985 • 209 citations

Flux of Ca2+ across the sarcoplasmic reticulum of guinea‐pig cardiac cells during excitation‐contraction coupling.

1991 • 209 citations

An estimate of the calcium content of the sarcoplasmic reticulum in rat ventricular myocytes

1993 • 205 citations

Voltage-Independent Calcium Release in Heart Muscle

1990 • 183 citations

Properties and regulation of calcium channels in muscle cells

1990 • 168 citations

Delayed afterdepolarizations in heart muscle: mechanisms and relevance.

1988 • 159 citations

Contractile and biochemical correlates of β-adrenergic stimulation of the aged heart

1980 • 148 citations

Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence

1989 • 135 citations

Age associated changes in membrane currents in rat ventricular myocytes

1993 • 127 citations

Age-associated decrease in heart rate response to isoproterenol in dogs

1979 • 113 citations

Age-related alterations in the phosphorylation of sarcoplasmic reticulum and myofibrillar proteins and diminished contractile response to isoproterenol in intact rat ventricle.

1993 • 88 citations

Calcium-dependent inactivation of the dihydropyridine-sensitive calcium channels in GH3 cells.

1988 • 83 citations

ATPase activity and force production in myofibrils and twitch characteristics in intact muscle from neonatal, adult, and senescent rat myocardium

1984 • 64 citations

Ca2+ dependence of alpha-adrenergic effects on the contractile properties and Ca2+ homeostasis of cardiac myocytes.

1991 • 53 citations

Deterioration of β‐Adrenergic Modulation of Cardiovascular Function with Aging

1992 • 50 citations

Decrease with senescence in the norepinephrine-induced phosphorylation of myofilament proteins in isolated rat cardiac myocytes

1989 • 47 citations

Contractile response of individual cardiac myocytes to norepinephrine declines with senescence

1992 • 46 citations

Ca2+ channel currents in rat sensory neurones: interaction between guanine nucleotides, cyclic AMP and Ca2+ channel ligands.

1991 • 37 citations

Interactive α- and β-adrenergic actions of norepinephrine in rat cardiac myocytes

1990 • 33 citations

Passive membrane properties of isolated feline ventricular myocytes

1985 • 9 citations