The significance of cell death by apoptosis in hepatobiliary disease

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Death in Embryonic Systems

1966 • 943 citations

Lysosomes in Biology and Pathology

1974 • 768 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Death and the cell

1986 • 616 citations

Histologic Diagnosis of Inflammatory Skin Diseases.

1979 • 604 citations

Cell death: a new classification separating apoptosis from necrosis

1981 • 575 citations

Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance.

1982 • 500 citations

Macrophage recognition of cells undergoing programmed cell death (apoptosis).

1985 • 460 citations

Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters

1984 • 369 citations

RELATION OF THE PORTAL BLOOD TO LIVER MAINTENANCE

1920 • 340 citations

Perspectives on mammalian cell death

1988 • 334 citations

A histochemical study of hypertrophy and ischaemic injury of rat liver with special reference to changes in lysosomes

1965 • 255 citations

A MORPHOMETRIC STUDY OF THE REMOVAL OF PHENOBARBITAL-INDUCED MEMBRANES FROM HEPATOCYTES AFTER CESSATION OF TREATMENT

1973 • 250 citations

Pattern of Necrosis in Acute Viral Hepatitis

1970 • 245 citations

A suggested explanation for the paradoxically slow growth rate of basal‐cell carcinomas that contain numerous mitotic figures

1972 • 227 citations

THE BIOLOGY OF CELL DEATH IN TUMOURS

1973 • 222 citations

Orthotopic Liver Transplantation: A Pathological Study of 63 Serial Liver Biopsies from 17 Patients with Special Reference to the Diagnostic Features and Natural History of Rejection†

1984 • 216 citations

Progress in Liver Diseases

1981 • 186 citations

Histologic Observations in Human Hepatitis Non-A, Non-B

1982 • 182 citations

Adrenocortical cell deletion: The role of ACTH

1973 • 180 citations

Occurrence of cell death (apoptosis) during the involution of liver hyperplasia.

1985 • 174 citations

Apoptosis. Its nature and implications for dermatopathology.

1979 • 162 citations

The mechanism of T cell mediated cytotoxicity II. morphological studies of cell death by time-lapse microcinematography

1976 • 146 citations

Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia

1986 • 144 citations

Apoptosis

1979 • 137 citations

THE NATURE OF PIECEMEAL NECROSIS IN CHRONIC ACTIVE HEPATITIS

1979 • 128 citations

Recent Advances in Histopathology

1984 • 127 citations

Cell death in the normal neonatal rat adrenal cortex

1973 • 121 citations

Occurrence of cell death (apoptosis) in preneoplastic and neoplastic liver cells. A sequential study.

1984 • 115 citations

Microcinematographic and electron microscopic analysis of target cell lysis induced by cytotoxic T lymphocytes.

1979 • 111 citations

THE PATHOLOGY OF EPIDEMIC HEPATITIS

1947 • 108 citations

Ultrastructural features in galactosamine-induced hepatitis

1970 • 94 citations

DEATH OF CELLS BY APOPTOSIS FOLLOWING ATTACHMENT OF SPECIFICALLY ALLERGIZED LYMPHOCYTES IN VITRO

1977 • 93 citations

Apoptosis, lymphocytotoxicity and the containment of viral infections

1985 • 92 citations

Liver Biopsy Interpretation

1980 • 81 citations

An electron‐microscope study of liver cell necrosis due to heliotrine

1969 • 80 citations

Ultrastructural lesions of bile ducts in primary biliary cirrhosis

1981 • 79 citations

Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus

1985 • 77 citations

The ultrastructure of acidophilic "Councilman-like" bodies in the liver.

1966 • 76 citations

Electron Microscopic Observations on Councilman-Like Acidophilic Bodies and Other Forms of Acidophilic Changes in Human Liver Cells.

1965 • 68 citations

Hepatic changes produced by a single dose of endotoxin in the mouse. Electron microscopy.

1968 • 65 citations

The portal blood supply and regeneration of the rat liver.

1955 • 58 citations

The mechanism of T cell mediated cytotoxicity V. Morphological studies by electron microscopy

1977 • 56 citations

Apoptosis as the mode of cell death in antibody-dependent lymphocytotoxicity

1985 • 52 citations

1,1-Dichloroethylene: an apoptotic hepatotoxin?

1984 • 48 citations

Differential Radiation Response Amongst Proliferating Epithelial Cells

1978 • 46 citations

Changes in DNA synthesis and cell proliferation during hepatocarcinogenesis by diethylnitrosamine

1967 • 43 citations

Electron microscopic observation of destruction of biliary epithelium in primary biliary cirrhosis

1983 • 41 citations

AN ELECTRON MICROSCOPIC STUDY OF THE MODE OF DONOR CELL DEATH IN UNMODIFIED REJECTION OF PIG LIVER ALLOGRAFTS

1977 • 39 citations

The stimulation of liver growth and demethylase activity following phenobarbital treatment

1968 • 39 citations

Chronic Delta Infection and Liver Biopsy Changes in Chronic Active Hepatitis B

1984 • 37 citations

Pathology of Viral Hepatitis and its Sequelae

1980 • 31 citations

An electron microscopic study of liver cell necrosis due to albitocin

1970 • 30 citations

Lysosome changes in acute liver injury due to heliotrine

1967 • 24 citations

The role of natural killer cells in the intravascular death of intravenously injected murine tumour cells

1983 • 24 citations

Another look at rejection in pig liver homografts.

1974 • 21 citations

The mechanism of K cell (antibody-dependent) cell mediated cytotoxicity II. Characteristics of the effector cell and morphological changes in the target cell

1977 • 20 citations

Electron microscopy of rejected human liver allografts

1985 • 16 citations

The Problem of Chronicity in Liver Disease

1965 • 13 citations

Acidophilic bodies. Their chemical and physical nature in patients with Bolivian hemorrhagic fever.

1968 • 12 citations

Zur Morphogenese der eosinophilen Einzelzellnekrose im Leberparenchym des Menschen

1967 • 11 citations

Effects of Rauscher Leukemia Virus Infection on BALB/ c Mouse Embryos

1976 • 11 citations

Liver Transplantation

1984 • 7 citations

Induction of liver lysosomal enzymes during the autophagic phase following phenobarbital treatment of rat

1977 • 7 citations

New aspects of piecemeal necrosis

1985 • 6 citations

Serum enzyme pattern in acute liver disease: Relation to type of cell death

1987 • 5 citations

The Histogenesis and Clinical Significance of Acidophilic Bodies in Various Liver Diseases

1968 • 5 citations