Long-Term Pharmacologic Neuroprotection after Birth Asphyxia: Where Do We Stand?

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Whole-Body Hypothermia for Neonates with Hypoxic–Ischemic Encephalopathy

2005 • 2,654 citations

Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial

2005 • 2,106 citations

Neonatal Brain Injury

2004 • 1,103 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Origin and timing of brain lesions in term infants with neonatal encephalopathy

2003 • 586 citations

Delayed (“Secondary”) Cerebral Energy Failure after Acute Hypoxia-Ischemia in the Newborn Piglet: Continuous 48-Hour Studies by Phosphorus Magnetic Resonance Spectroscopy

1994 • 548 citations

Inflammatory Neurodegeneration Mediated by Nitric Oxide, Glutamate, and Mitochondria

2003 • 450 citations

Allopurinol and oxypurinol are hydroxyl radical scavengers

1987 • 393 citations

Superoxide Reacts with Nitric Oxide to Nitrate Tyrosine at Physiological pH via Peroxynitrite

2000 • 387 citations

Oxidative Stress in the Newborn – A 30-Year Perspective

2005 • 349 citations

CEREBRAL ENERGY METABOLISM STUDIED WITH PHOSPHORUS NMR SPECTROSCOPY IN NORMAL AND BIRTH-ASPHYXIATED INFANTS

1984 • 312 citations

Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia

2005 • 267 citations

Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector?

2002 • 215 citations

Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats.

1994 • 207 citations

Effect of Allopurinol on Postasphyxial Free Radical Formation, Cerebral Hemodynamics, and Electrical Brain Activity

1998 • 197 citations

Neonatal Mice Lacking Neuronal Nitric Oxide Synthase Are Less Vulnerable to Hypoxic–Ischemic Injury

1996 • 192 citations

Hsp70 Overexpression Sequesters AIF and Reduces Neonatal Hypoxic/Ischemic Brain Injury

2005 • 189 citations

Antibodies against Adhesion Molecules Reduce Apoptosis after Transient Middle Cerebral Artery Occlusion in Rat Brain

1996 • 188 citations

Allopurinol Administered after Inducing Hypoxia-Ischemia Reduces Brain Injury in 7-Day-Old Rats

1993 • 166 citations

Erythropoietin in the central nervous system, and its use to prevent hypoxic‐ischemic brain damage

2002 • 166 citations

High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia: A randomized, prospective study with three-year follow-up

1998 • 165 citations

The Good, the Bad, and the Cell Type-Specific Roles of Hypoxia Inducible Factor-1α in Neurons and Astrocytes

2008 • 161 citations

Role of Xanthine Oxidase and Its Inhibitor in Hypoxia: Reoxygenation Injury

1996 • 154 citations

Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia

2008 • 150 citations

Hypoxic-Ischemic Injury Stimulates Subventricular Zone Proliferation and Neurogenesis in the Neonatal Rat

2005 • 143 citations

Erythropoietin after Focal Cerebral Ischemia Activates the Janus Kinase–Signal Transducer and Activator of Transcription Signaling Pathway and Improves Brain Injury in Postnatal Day 7 Rats

2005 • 140 citations

Gender-Specific Neuroprotection by 2-Iminobiotin after Hypoxia—Ischemia in the Neonatal Rat via a Nitric Oxide Independent Pathway

2006 • 121 citations

Strong Neuroprotection by Inhibition of NF-κB After Neonatal Hypoxia-Ischemia Involves Apoptotic Mechanisms but Is Independent of Cytokines

2008 • 116 citations

Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia

2005 • 114 citations

Lipid peroxidation in developing fetal guinea pig brain during normoxia and hypoxia

1989 • 114 citations

Effects of Allopurinol and Deferoxamine on Reperfusion Injury of the Brain in Newborn Piglets after Neonatal Hypoxia-Ischemia

2003 • 108 citations

Hypoxia-inducible factor 1α and erythropoietin upregulation with deferoxamine salvage after neonatal stroke

2005 • 105 citations

A Dual Role of the NF-κB Pathway in Neonatal Hypoxic-Ischemic Brain Damage

2008 • 104 citations

Potential for Protection and Repair Following Injury to the Developing Brain: A Role for Erythropoietin?

2005 • 100 citations

TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic–ischemic brain injury via inhibition of caspases and AIF

2005 • 98 citations

The Use Of A Calcium‐Channel Blocker, Nicardipine, For Severely Asphyxiated Newborn Infants

1990 • 89 citations

Effect of Allopurinol Supplementation on Nitric Oxide Levels in Asphyxiated Newborns

2006 • 84 citations

Hypoxia-induced generation of nitric oxide free radicals in cerebral cortex of newborn guinea pigs.

2000 • 81 citations

Effect of hyperbaric oxygen on apoptosis in neonatal hypoxia-ischemia rat model

2003 • 81 citations

Free Radicals Are Formed in the Brain of Fetal Sheep during Reperfusion after Cerebral Ischemia

1998 • 74 citations

Gender differences in long-term beneficial effects of erythropoietin given after neonatal stroke in postnatal day-7 rats

2006 • 74 citations

Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia–ischemia in the neonatal rat brain

2005 • 72 citations

Effect of deferoxamine and allopurinol on non-protein-bound iron concentrations in plasma and cortical brain tissue of newborn lambs following hypoxia-ischemia

1998 • 72 citations

Endothelial activation and induction of monocyte adhesion by nontransferrin‐bound iron present in human sera

2005 • 72 citations

Increase in nitric oxide in the hypoxic–ischemic neonatal rat brain and suppression by 7-nitroindazole and aminoguanidine

1998 • 70 citations

Formation of free radicals in hypoxic ischemic brain damage in the neonatal rat, assessed by an endogenous spin trap and lipid peroxidation

1997 • 69 citations

Free radical production and changes in superoxide dismutases associated with hypoxia/reoxygenation-induced apoptosis of embryonic rat forebrain neurons in culture

2000 • 67 citations

The effect of pentobarbital anesthesia on resuscitation and brain damage in fetal rhesus monkeys asphyxiated on delivery

1969 • 61 citations

Long-Term Neuroprotection with 2-Iminobiotin, An Inhibitor of Neuronal and Inducible Nitric Oxide Synthase, after Cerebral Hypoxia-Ischemia in Neonatal Rats

2005 • 59 citations

Treatment of hypoxic-ischemic encephalopathy in newborns

2007 • 55 citations

L-Carnitine Reduces Brain Injury after Hypoxia-Ischemia in Newborn Rats

2003 • 54 citations

Brain-orientated intensive care treatment in severe neonatal asphyxia. Effects of phenobarbitone protection.

1982 • 54 citations

Temporal evolution of neuronal changes in cerebral hypoxia– ischemia in developing rats: a quantitative light microscopic study

1998 • 53 citations

Effects of magnesium sulphate on amplitude‐integrated continuous EEG in asphyxiated term neonates

2002 • 51 citations

Neurodevelopmental outcome of infants with birth asphyxia treated with magnesium sulfate

2006 • 39 citations

Effects of Hypoxia and Reoxygenation on Nitric Oxide Production and Cerebral Blood Flow in Developing Rat Striatum

1998 • 37 citations

Inhibition of nNOS and iNOS following Hypoxia-Ischaemia Improves Long-Term Outcome but Does Not Influence the Inflammatory Response in the Neonatal Rat Brain

2002 • 36 citations

Current controversies in hypothermic neuroprotection

2007 • 36 citations

Hypoxic-ischemic injury in the neonatal rat brain: effects of pre-and post-treatment with the glutamate release inhibitor BW1003C87

1994 • 34 citations

The effect of a global birth asphyxia on the ontogeny of BDNF and NGF protein expression in the juvenile brain

2003 • 33 citations

Single intravenous injection of naked plasmid DNA encoding erythropoietin provides neuroprotection in hypoxia–ischemia rats

2004 • 33 citations

Toxic Effects Associated With the Administration of Deferoxamine in the Premature Baboon With Hyaline Membrane Disease

1990 • 30 citations

Plasticity of Neurons and Glia Following Neonatal Hypoxic-Ischemic Brain Injury in Rats

2006 • 28 citations

Medical and surgical treatment of neonatal hemochromatosis: Single center experience

2007 • 26 citations

Mannitol in neonatal cerebral oedema

1990 • 20 citations

Timing Is Everything – Delaying Therapy for Delayed Cell Death

2002 • 19 citations

Resuscitation with 21 or 100% Oxygen in Hypoxic Nicotine-Pretreated Newborn Piglets: Possible Neuroprotective Effects of Nicotine

2007 • 19 citations

Effect of neonatal body temperature on postanoxic, potentially neurotoxic iron accumulation in the rat brain

2005 • 19 citations

Antioxidant Activity in the Newborn Brain: A Luciferase Mouse Model

2007 • 18 citations

Effect of Cyclooxygenase Inhibition on Brain Cell Membrane Lipid Peroxidation during Hypoxia in Newborn Piglets

1994 • 18 citations

Selective Inhibition of Nuclear Factor-κB Activation After Hypoxia/Ischemia in Neonatal Rats Is Not Neuroprotective

2006 • 18 citations

Deleted Work

1955 • 0 citations