Retroviral Gene Therapy in ApoE-Deficient Mice

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Quantitative assessment of atherosclerotic lesions in mice

1987 • 957 citations

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production.

1986 • 828 citations

Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo

1992 • 749 citations

THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES

1965 • 704 citations

Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression.

1994 • 632 citations

Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice

1995 • 518 citations

Prevention of Atherosclerosis in Apolipoprotein E-Deficient Mice by Bone Marrow Transplantation

1995 • 467 citations

Cytostatic Gene Therapy for Vascular Proliferative Disorders with a Constitutively Active form of the Retinoblastoma Gene Product

1995 • 455 citations

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.

1984 • 365 citations

Rapid Cell Culture Assay Technique for Murine Leukaemia Viruses

1971 • 360 citations

Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.

1990 • 338 citations

Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.

1991 • 334 citations

Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E.

1981 • 302 citations

Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

1997 • 285 citations

Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.

1995 • 279 citations

Gene Therapy for Cardiovascular Disease

1995 • 229 citations

Apolipoprotein E synthesis in human kidney, adrenal gland, and liver.

1983 • 224 citations

Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans.

1994 • 211 citations

In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.

1994 • 184 citations

Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells.

1988 • 174 citations

Independent Pathways for Secretion of Cholesterol and Apolipoprotein E by Macrophages

1983 • 162 citations

Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.

1995 • 135 citations

Expression of heterologous human apolipoprotein E by J774 macrophages enhances cholesterol efflux to HDL3.

1994 • 135 citations

Apolipoprotein E Inhibition of Proliferation of Mitogen-Activated T Lymphocytes: Production of Interleukin 2 with Reduced Biological Activity

1994 • 126 citations

Apolipoprotein E secretion by macrophages: its potential physiological functions

1996 • 118 citations

Binding of apoE-rich high density lipoprotein particles by saturable sites on human blood platelets inhibits agonist-induced platelet aggregation.

1989 • 114 citations

Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E.

1993 • 70 citations

Localization of a Domain in Apolipoprotein E with both Cytostatic and Cytotoxic Activity

1995 • 58 citations

Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-binding-defective apolipoprotein E variant.

1994 • 24 citations

Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma.

1993 • 23 citations

Differentiation of chimeric bone marrow in vivo reveals genotype-restricted contributions to hematopoiesis.

1991 • 23 citations

Gene Therapy for Cardiovascular Diseases

1996 • 10 citations