Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma.

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

1990 • 2,936 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Human apolipoprotein E. The complete amino acid sequence.

1982 • 731 citations

Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E

1991 • 661 citations

Familial hyperlipoproteinemia type III: Deficiency of a specific apolipoprotein (APO E‐III) in the very‐low‐density lipoproteins

1975 • 342 citations

Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts.

1979 • 303 citations

Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.

1990 • 289 citations

Human Apolipoprotein E

1989 • 238 citations

Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.

1984 • 188 citations

Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation.

1984 • 178 citations

[13] Isolation and characterization of apolipoprotein E

1986 • 155 citations

Apolipoprotein E2-Christchurch (136 Arg----Ser). New variant of human apolipoprotein E in a patient with type III hyperlipoproteinemia.

1987 • 152 citations

Glycosylation of Human Apolipoprotein E

1989 • 147 citations

Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype.

1983 • 146 citations

Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant.

1989 • 103 citations

Apolipoprotein E3-Leiden. A new variant of human apolipoprotein E associated with familial type III hyperlipoproteinemia

1986 • 97 citations

Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigree.

1991 • 94 citations

Apolipoprotein E

1990 • 91 citations

The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia.

1992 • 89 citations

Human apolipoprotein E expression in Escherichia coli: structural and functional identity of the bacterially produced protein with plasma apolipoprotein E.

1985 • 88 citations

Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121–127

1989 • 81 citations

Genetic heterogeneity in familial dysbetalipoproteinemia. The E2(lys146—-gln) variant results in a dominant mode of inheritance.

1990 • 73 citations

Apolipoprotein E*3-Leiden allele results from a partial gene duplication in exon 4

1989 • 56 citations

Synthesis and secretion of apolipoprotein E occur independently of synthesis and secretion of apolipoprotein B-containing lipoproteins in HepG2 cells.

1992 • 50 citations

Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide probes

1988 • 43 citations

Functionally inactive apolipoprotein E₃ in a type III hyperlipoproteinaemic patient

1984 • 31 citations

Biogenesis of plasma lipoproteins in rat hepatoma McA-RH7777: Importance of diffusion-mediated events during cell growth

1989 • 30 citations

Apolipoprotein E

1982 • 22 citations

Apolipoprotein E (role in lipoprotein metabolism and pathophysiology of hyperlipoproteinemia type III).

1982 • 16 citations