Low-dose apomorphine attenuates morphine-induced enhancement of brain stimulation reward

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Opioids excite dopamine neurons by hyperpolarization of local interneurons

1992 • 1,585 citations

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

1984 • 644 citations

Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

1982 • 560 citations

Morphine-induced activation of A10 dopamine neurons in the rat

1983 • 485 citations

Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine

1984 • 424 citations

Regulation of somatodendritic dopamine release in the ventral tegmental area by opioids and GABA: an in vivo microdialysis study

1992 • 311 citations

Euphorigenic drugs: effects on the reward pathways of the brain.

1979 • 299 citations

Behavioural neuroscience : a practical approach

1993 • 238 citations

Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens

1985 • 232 citations

Morphine-dopamine interaction: Ventral tegmental morphine increases nucleus accumbens dopamine release

1991 • 218 citations

A10 dopamine neurons: Role of autoreceptors in determining firing rate and sensitivity to dopamine agonists

1984 • 203 citations

Amphetamine-type reinforcement by dopaminergic agonists in the rat

1978 • 182 citations

Locomotor activity and antinociception after putative mu, kappa and sigma opioid receptor agonists in the rat: influence of dopaminergic agonists and antagonists.

1981 • 176 citations

Morphine Lowering of Self-Stimulation Thresholds: Lack of Tolerance with Long-Term Administration

1977 • 171 citations

Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin

1987 • 164 citations

Self-injection of apomorphine in the rat: Positive reinforcement by a dopamine receptor stimulant

1974 • 147 citations

Effects of d-amphetamine and naloxone on brain stimulation reward

1980 • 122 citations

Facilitation of self-stimulation behavior following intracerebral microinjections of opioids into the ventral tegmental area

1979 • 120 citations

Naloxone attenuation of the effect of cocaine on rewarding brain stimulation

1987 • 107 citations

Effects of 6-OHDA lesions of the central medial nucleus accumbens on rat intravenous morphine self-administration

1985 • 86 citations

Opioid-neuroleptic interaction in brainstem self-stimulation

1989 • 52 citations

Presynaptic autoinhibition of the electrically evoked dopamine release studied in the rat olfactory tubercle byin vivo electrochemistry

1991 • 52 citations

6-OHDA lesions of the ventral tegmental area block morphine-induced but not amphetamine-induced facilitation of self-stimulation

1985 • 51 citations

Heroin, 6-acetylmorphine and morphine effects on threshold for rewarding and aversive brain stimulation.

1992 • 50 citations

Effects of apomorphine on self-stimulation behavior

1974 • 45 citations

Opiate actions on mesocortical dopamine metabolism in the rat

1986 • 33 citations

Effects of apomorphine on self-stimulation responding: Does the drug mimic the current?

1983 • 25 citations

Dopaminergic and cholinergic influences on morphine self-administration in rats.

1975 • 24 citations

Apomorphine and electrical self-stimulation of rat brain

1992 • 24 citations

Effects of morphine on intracranial self-stimulation to various brain stem loci

1979 • 22 citations

The combined effects of morphine and d-amphetamine on the threshold for brain stimulation reward

1987 • 21 citations

The effect of amfonelic acid or nisoxetine in combination with morphine on brain-stimulation reward

1989 • 19 citations

The reinforcing properties of the mixed agonist-antagonist buprenorphine as assessed by brain-stimulation reward

1988 • 18 citations

Effects of morphine on dopamine metabolism in rat striatum and limbic structures in relation to the activity of dopaminergic neurones

1984 • 18 citations

Site of rewarding action of morphine in the mesolimbic system determined by intracranial electrical self-stimulation

1985 • 17 citations

Bromocriptine, a D2 receptor agonist, lowers the threshold for rewarding brain stimulation

1994 • 17 citations

The effects of amfonelic acid alone and in combination with naloxone on brain-stimulation reward

1989 • 15 citations

Interactions of morphine with apomorphine: behavioural and biochemical studies

1986 • 15 citations

Effects of concomitant pentazocine and tripelennamine on brain-stimulation reward

1984 • 14 citations

Apomorphine-induced facilitation of intracranial self-stimulation following dopamine denervation of the nucleus accumbens

1982 • 9 citations

Rate dependent inhibition of self-stimulation by apomorphine

1982 • 9 citations

Effects of nalbuphine alone and in combination with tripelennamine on rewarding brain stimulation thresholds in the rat

1986 • 8 citations

Avoidance and ICSS behavioral models dissociate TL-99 and 3-PPP from dopamine receptor antagonists

1983 • 8 citations

Dopaminergic agents including 3-PPP and its enantiomers on medial septal self-stimulation

1985 • 4 citations