Free Radicals and Antioxidant Protection: Mechanisms and Significance in Toxicology and Disease

Free radicals in biology and medicine

1991 • 17,840 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Free Radical Mechanisms in Tissue Injury

1988 • 1,585 citations

Free-radical mechanisms in tissue injury

1984 • 1,518 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Free-radical chemistry of cigarette smoke and its toxicological implications.

1985 • 1,351 citations

Free Radicals in Biology and Medicine

1986 • 1,339 citations

Biochemistry of Oxidative Stress

1986 • 1,307 citations

Superoxide Radical: An Endogenous Toxicant

1983 • 1,176 citations

The importance of free radicals and catalytic metal ions in human diseases

1985 • 939 citations

LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY

1984 • 820 citations

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

1986 • 634 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes

1982 • 614 citations

The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase

1986 • 551 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

A new role for phospholipase A2: protection of membranes from lipid peroxidation damage

1987 • 428 citations

Allopurinol and oxypurinol are hydroxyl radical scavengers

1987 • 393 citations

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.

1984 • 392 citations

The measurement of free radical reactions in humans

1987 • 325 citations

DNA strand breaks, NAD metabolism, and programmed cell death

1986 • 303 citations

The production of free radicals during the autoxidation of cysteine and their effect on isolated rat hepatocytes

1982 • 283 citations

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?

1987 • 253 citations

Iron and free radical reactions: two aspects of antioxidant protection

1986 • 249 citations

Cigarette smoke induces DNA single-strand breaks in human cells

1985 • 248 citations

Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo?

1987 • 240 citations

Philosophical Transactions of the Royal Society

2010 • 232 citations

ANTIOXIDANT PROTECTION: A FUNCTION OF TRACHEOBRONCHIAL AND GASTROINTESTINAL MUCUS

1984 • 231 citations

Antioxidant properties of the proteins caeruloplasmin, albumin and transferrin. A study of their activity in serum and synovial fluid from patients with rheumatoid arthritis

1986 • 213 citations

Site-specific modification of albumin by free radicals. Reaction with copper(II) and ascorbate

1986 • 212 citations

Biologically significant scavenging of the myeloperoxidase‐derived oxidant hypochlorous acid by ascorbic acid

1987 • 189 citations

Aspects to Consider When Detecting and Measuring Lipid Peroxidation

1986 • 172 citations

Characterization of free radical-induced base damage in DNA at biologically relevant levels

1986 • 160 citations

Oxidant injury of cells.

1987 • 135 citations

Correlation between cytotoxic effect of hydrogen peroxide and the yield of DNA strand breaks in cells of different species

1984 • 124 citations

Selective Toxicity

1985 • 119 citations

Biochemistry of reduction of nitro heterocycles

1986 • 102 citations

Metabolic aspects of antioxidants and preservatives

1986 • 79 citations

Endogenous free radical generation may influence proteolysis in Mitochondria

1985 • 76 citations

Effects of Oxidative Stress Caused by Hyperoxia and Diquat. A Study in Isolated Hepatocytes

1986 • 64 citations

Measurement of the diene conjugated form of linoleic acid in plasma by high performance liquid chromatography: A questionable non-invasive assay of free radical activity?

1985 • 55 citations

Therapeutic benefits of oxygen radical scavenger treatments remain unproven

1985 • 40 citations

Oxidative stress studied in intact mammalian cells

1985 • 35 citations

Dioxygen-derived radicals in biological systems

1985 • 6 citations

Free radical metabolites of toxic chemicals.

1985 • 5 citations