An hypothesis regarding the antipsychotic effect of neuroleptic drugs

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

The Pharmacological Basis of Therapeutics

1986 • 2,365 citations

Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain

1977 • 1,017 citations

Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines

1984 • 866 citations

THE CORTICO-STRIATE PROJECTION IN THE MONKEY

1970 • 790 citations

Psychopharmacology: A generation of progress

1978 • 785 citations

A study of supersensitivity in denervated mammalian skeletal muscle

1959 • 737 citations

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1980 • 703 citations

The neurosciences. Third study program

1975 • 623 citations

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

1983 • 589 citations

Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency

1980 • 543 citations

An intricately patterned prefronto‐caudate projection in the rhesus monkey

1977 • 506 citations

A glutamatergic corticostriatal path?

1977 • 487 citations

Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum

1984 • 467 citations

MECHANISM OF THE ANTIPSYCHOTIC EFFECT IN THE TREATMENT OF ACUTE SCHIZOPHRENIA

1978 • 464 citations

Monosynaptic cortical input and local axon collaterals of identified striatonigral neurons. A light and electron microscopic study using the golgi‐peroxidase transport‐degeneration procedure

1981 • 455 citations

Behavioural supersensitivity to apomorphine following chronic treatment with drugs which interfere with the synaptic function of catecholamines

1974 • 451 citations

The striatal cholinergic interneuron: Synaptic target of dopaminergic terminals?

1983 • 422 citations

Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum

1978 • 401 citations

Anesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microelectrophoresis.

1965 • 395 citations

A Quantitative Study on the Nigro‐Neostriatal Dopamine Neuron System in the Rat

1966 • 374 citations

Antagonism of cortical excitation of striatal neurons by glutamic acid diethyl ester: Evidence for glutamic acid as an excitatory transmitter in the rat striatum

1976 • 343 citations

Cortico-striate interrelations in the albino rat.

1961 • 327 citations

STIMULATORY EFFECT OF <scp>l</scp>‐GLUTAMATE AND RELATED AMINO ACIDS ON [³H]DOPAMINE RELEASE FROM RAT STRIATUM: AN IN VITRO MODEL FOR GLUTAMATE ACTIONS

1979 • 315 citations

Monosynaptic inputs to caudate neurons identified by intracellular injection of horseradish peroxidase

1976 • 313 citations

Receptors for the excitatory amino acids in the mammalian central nervous system

1983 • 292 citations

Neuroleptic drug interactions with norepinephrine alpha receptor binding sites in rat brain

1977 • 290 citations

Tolerance phenomena with neuroleptics catalepsy, apomorphine stereotypies and striatal dopamine metabolism in the rat after single and repeated administration of loxapine and haloperidol

1973 • 256 citations

Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding

1979 • 237 citations

Phenothiazine Effects on Psychological and Psychophysiological Dysfunction in Chronic Schizophrenics

1977 • 235 citations

Neuroleptics : neurochemical, behavioral, and clinical perspectives

1983 • 230 citations

The subcortical afferents to caudate nucleus and putamen in primate: A fluorescence retrograde double labeling study

1983 • 230 citations

Distribution of [3H]AMPA binding sites in rat brain as determined by quantitative autoradiography

1984 • 229 citations

The Binding of [³H]AMPA, a Structural Analogue of Glutamic Acid, to Rat Brain Membranes

1982 • 223 citations

Quantification of the dopamine innervation in adult rat neostriatum

1986 • 216 citations

Interactions between dopamine and amino acid-induced excitation and inhibition in the striatum

1986 • 211 citations

Electron and Fluorescence Microscopical Studies on the Nucleus Gaudatus Putamen of the Rat after Unilateral Lesions of Ascending Nigro‐Neostriatal Dopamine Neurons

1969 • 204 citations

Dopamine receptors: Pharmacological and anatomical evidences indicate that two distinct dopamine receptor populations are present in rat striatum

1978 • 203 citations

Pharmacology of the corticocaudate excitatory postsynaptic potential in the cat: Evidence for its mediation by quisqualateor kainate-receptors

1985 • 201 citations

Postjunctional supersensitivity and subsensitivity of excitable tissues to drugs

1973 • 200 citations

Withdrawal syndromes associated with antipsychotic drugs

1978 • 192 citations

Effects of excitatory amino acids and their antagonists on membrane and action potentials of cat caudate neurones.

1983 • 182 citations

Topographical distribution of possible glutamatergic pathways from the frontal cortex to the striatum and substantia nigra in rats

1982 • 171 citations

Iontophoretically applied dopamine depolarizes and hyperpolarizes the membrane of cat caudate neurons

1980 • 168 citations

Increased sensitivity to dopaminergic agents after chronic neuroleptic treatment.

1975 • 161 citations

Effect of Motor and Premotor Cortex Ablation on Concentrations of Amino Acids, Monoamines, and Acetylcholine and on the Ultrastructure in Rat Striatum. A Confirmation of Glutamate as the Specific Cortico‐Striatal Transmitter

1982 • 153 citations

Drug Therapy in Schizophrenia

1960 • 140 citations

Organization of the ascending striatal afferents in monkeys

1980 • 140 citations

The electrophysiology of dopamine (D2) receptors: A study of the actions of dopamine on corticostriatal transmission

1983 • 137 citations

On the supersensitivity of dopamine receptors, induced by neuroleptics

1976 • 135 citations

Striatal glutamatergic function: Modifications following specific lesions

1982 • 133 citations

Haloperidol: Effect of Long-Term Treatment on Rat Striatal Dopamine Synthesis and Turnover

1977 • 123 citations

The effect of chronic neuroleptic administration on cerebral dopamine receptor function

1983 • 113 citations

Short-Term increase and long-term reversion of striatal cell activity after degeneration of the nigrostriatal dopamine system

1978 • 110 citations

Excitatory Amino Acid Neurotransmitters in the Corticostriate Pathway: Studies Using Intracerebral Microdialysis In Vivo

1986 • 109 citations

Pressure—volume relationships in the chest before and after death

1959 • 101 citations

Origins of postsynaptic potentials evoked in identified rat neostriatal neurons by stimulation in substantia nigra

1982 • 99 citations

On the use of lesions of afferents to localize neurotransmitter receptor sites in the striatum

1982 • 84 citations

Synthesis of acetylcholine receptor by denervated rat diaphragm muscle.

1975 • 82 citations

Possible modulating influence of frontal cortex on nigro‐striatal function

1973 • 81 citations

Ranking of excitatory amino acids by the antagonists glutamic acid diethylester and <scp>D</scp>-α-aminoadipic acid

1978 • 76 citations

Predictability in Psychopharmacology: Preclinical and Clinical Correlations

1976 • 76 citations

A relatively nonspecific supersensitivity in aortic strips resulting from pretreatment with reserpine.

1966 • 72 citations

Kainic acid lesions of striatum and decortication reduce specific [3H]sulpiride binding in rats, so D-2 receptors exist post-synaptically on corticostriate afferents and striatal neurons

1981 • 69 citations

Presynaptic dopaminergic control of high affinity glutamate uptake in the striatum

1983 • 67 citations

The role of cholinergic supersensitivity in the medical symptoms associated with withdrawal of antipsychotic drugs

1980 • 58 citations

A quantitative analysis of the excitatory and depressant effects of dopamine on the firing of caudatal neurons: electrophysiological support for the existence of two distinct dopamine-sensitive receptors

1978 • 57 citations

The effect of decortication on the excitatory amino acid sensitivity of striatal neurones

1980 • 57 citations

The demonstration of a change in adrenergic receptor sensitivity in the central nervous system of mice after withdrawal from long-term treatment with haloperidol

1976 • 52 citations

Alteration in the action of cholinergic and anti cholinergic drugs after chronic haloperidol: Indirect evidence for cholinergic hyposensitivity

1976 • 45 citations

Effects of chronic amphetamine treatment on the glutamate concentration in cerebrospinal fluid and brain: Implications for a theory of schizophrenia

1981 • 42 citations

Anomalous behavioral response to imidazoleacetic acid, a GABA agonist, in animals treated chronically with haloperidol.

1980 • 39 citations

Electrophysiological study of the effects of D1 and D2 dopamine antagonists on the interaction of converging inputs from the sensory-motor cortex and substantia nigra neurons in the rat

1986 • 33 citations

Morphological changes in the rat supraoptic and paraventricular nuclei during the diurnal cycle

1978 • 23 citations

The specificity of neuroleptic- and methysergide-induced behavioral hypersensitivity

1977 • 20 citations

Chronic neuroleptic treatment specifically alters the number of dopamine receptors in rat brain

1981 • 20 citations

Denervation Supersensitivity

1975 • 14 citations

Acidic amino acid receptor nomenclature: time for change

1988 • 13 citations

Effects of chronic haloperidol on caudate 3H-spiroperidol binding in lesioned rats

1979 • 11 citations

Functional characteristics ofl-glutamate,N-methyl-d-aspartate and kainate receptors in isolated brain synaptic membranes

1984 • 11 citations

Acute and chronic haloperidol treatment: effects on nigrostriatal dopaminergic system activity.

1980 • 10 citations

Cortical ablation fails to influence striatal dopamine target cell supersensitivity induced by nigrostriatal denervation in the rat

1987 • 9 citations

Effects of nigral and cortical stimulation on caudate carbohydrate metabolism

1978 • 7 citations