Mechanism of agrin‐induced acetylcholine receptor aggregation

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

The Agrin Hypothesis

1990 • 637 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

Multiple forms of acetylcholinesterase and their distribution in endplate and non‐endplate regions of rat diaphragm muscle

1973 • 505 citations

Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis

1986 • 472 citations

Identification of agrin, a synaptic organizing protein from Torpedo electric organ.

1987 • 467 citations

Nerve‐induced and spontaneous redistribution of acetylcholine receptors on cultured muscle cells.

1977 • 459 citations

Synapse formation between dissociated nerve and muscle cells in low density cell cultures

1972 • 456 citations

Regulation of neurotransmitter receptor desensitization by protein phosphorylation

1990 • 439 citations

Lateral motion of fluorescently labeled acetylcholine receptors in membranes of developing muscle fibers.

1976 • 383 citations

Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve.

1979 • 355 citations

Developmental Regulation of Nicotinic Acetylcholine Receptors

1987 • 354 citations

Structure and expression of a rat agrin

1991 • 310 citations

Neural factors regulate AChR subunit mRNAs at rat neuromuscular synapses.

1991 • 256 citations

Agrin induces phosphorylation of the nicotinic acetylcholine receptor

1991 • 253 citations

The agrin gene codes for a family of basal lamina proteins that differ in function and distribution

1992 • 252 citations

Components of Torpedo electric organ and muscle that cause aggregation of acetylcholine receptors on cultured muscle cells.

1984 • 251 citations

Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation

1988 • 250 citations

Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways.

1987 • 247 citations

The postsynaptic 43k protein clusters muscle nicotinic acetylcholine receptors in xenopus oocytes

1990 • 237 citations

Agrin released by motor neurons induces the aggregation of acetylcholine receptors at neuromuscular junctions

1992 • 231 citations

ACh Receptor-Rich Membrane Domains Organized in Fibroblasts by Recombinant 43-Kilodalton Protein

1991 • 202 citations

cDNA that encodes active agrin

1992 • 199 citations

Crosslinking of proteins in acetylcholine receptor-rich membranes: Association between the β-subunit and the 43 kd subsynaptic protein

1983 • 197 citations

Development of the Neuromuscular Junction: Inductive Interactions Between Cells

1981 • 196 citations

Studies of the composition of purified Torpedo californica acetylcholine receptor and of its subunits

1979 • 193 citations

cAMP-dependent protein kinase phosphorylates the nicotinic acetylcholine receptor

1983 • 187 citations

The submembrane machinery for nicotinic acetylcholine receptor clustering.

1991 • 176 citations

Agrin-induced specializations contain cytoplasmic, membrane, and extracellular matrix-associated components of the postsynaptic apparatus

1989 • 163 citations

The influence of basal lamina on the accumulation of acetylcholine receptors at synaptic sites in regenerating muscle.

1984 • 135 citations

Regulation of agrin-induced acetylcholine receptor aggregation by Ca++ and phorbol ester.

1988 • 130 citations

Regulation of tyrosine phosphorylation of the nicotinic acetylcholine receptor at the rat neuromuscular lunction

1990 • 130 citations

Acetylcholine receptor-aggregating factor is similar to molecules concentrated at neuromuscular junctions

1985 • 117 citations

Induction of synaptic development in cultured muscle cells by basic fibroblast growth factor

1991 • 116 citations

Agrin mediates cell contact-induced acetylcholine receptor clustering

1991 • 113 citations

Phosphorylation affects voltage gating of the delayed rectifier K+ channel by electrostatic interactions

1990 • 112 citations

On the mechanism of acetylcholine receptor accumulation at newly formed synapses on chick myotubes

1985 • 111 citations

Localization of the inositol 1,4,5-trisphosphate receptor in synaptic terminals in the vertebrate retina

1991 • 110 citations

Interaction of the cytoskeletal framework with acetylcholine receptor on th surface of embryonic muscle cells in culture.

1982 • 106 citations

Agrin-related molecules are concentrated at acetylcholine receptor clusters in normal and aneural developing muscle.

1989 • 104 citations

Acetylcholine receptor-inducing factor from chicken brain increases the level of mRNA encoding the receptor alpha subunit.

1988 • 93 citations

Basal lamina directs acetylcholinesterase accumulation at synaptic sites in regenerating muscle.

1985 • 89 citations

The 43-K protein, v1, associated with acetylcholine receptor containing membrane fragments is an actin-binding protein.

1984 • 88 citations

Aggregating factor from Torpedo electric organ induces patches containing acetylcholine receptors, acetylcholinesterase, and butyrylcholinesterase on cultured myotubes.

1986 • 83 citations

Molecules in Basal Lamina That Direct the Formation of Synaptic Specializations at Neuromuscular Junctions

1989 • 83 citations

Formation of postsynaptic specializations induced by latex beads in cultured muscle cells

1982 • 82 citations

Early appearance of and neuronal contribution to agrin-like molecules at embryonic frog nerve-muscle synapses formed in culture

1992 • 77 citations

Inhibition of agrin-induced acetylcholine-receptor aggregation by heparin, heparan sulfate, and other polyanions

1990 • 77 citations

The putative agrin receptor binds ligand in a calcium-dependent manner and aggregates during agrin-induced acetylcholine receptor clustering

1991 • 75 citations

The role of the postsynaptic cytoskeleton in AChR organization

1986 • 74 citations

Basal lamina components are concentrated in premuscle masses and at early acetylcholine receptor clusters in chick embryo hindlimb muscles

1988 • 71 citations

Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor

1989 • 69 citations

Acetylcholine receptor-aggregating proteins are associated with the extracellular matrix of many tissues in Torpedo.

1988 • 68 citations

Neural influence on the postnatal changes in acetylcholine receptor distribution at nerve-muscle junctions in the mouse

1982 • 67 citations

The absence of calcium blocks impulse-evoked release of acetylcholine but not de novo formation of functional neuromuscular synaptic contacts in culture

1984 • 67 citations

Protein Phosphorylation of Nicotinic Acetylcholine Receptor

1989 • 63 citations

Induction of phosphorylation and cell surface redistribution of acetylcholine receptors by phorbol ester and carbamylcholine in cultured chick muscle cells.

1988 • 62 citations

Agrin-induced reorganization of extracellular matrix components on cultured myotubes: relationship to AChR aggregation.

1990 • 53 citations

Acetylcholine receptor alpha-subunit mRNA is increased by ascorbic acid in cloned L5 muscle cells: Northern blot analysis and in situ hybridization.

1989 • 51 citations

Phosphorylation and assembly of nicotinic acetylcholine receptor subunits in cultured chick muscle cells.

1987 • 49 citations

Cyclic AMP stabilizes the degradation of original junctional acetylcholine receptors in denervated muscle

1991 • 47 citations

Muscle-derived agrin in cultured myotubes: Expression in the basal lamina and at induced acetylcholine receptor clusters

1992 • 47 citations

Formation of acetylcholine receptor clusters in chick myotubes: migration or new insertion?

1989 • 37 citations

Heparin and heparan sulfate partially inhibit induction of acetylcholine receptor accumulation by nerve in Xenopus culture

1989 • 36 citations

Transformation by Rous sarcoma virus prevents acetylcholine receptor clustering on cultured chicken muscle fibers.

1984 • 29 citations

The mechanism of agrin-induced acetylcholine receptor aggregation

1991 • 21 citations

A factor from neurons induces partial immobilization of nonclustered acetylcholine receptors on cultured muscle cells.

1981 • 19 citations

Acetylcholine receptor clustering and triton solubility: Neural effect

1988 • 18 citations

A molecular defect in virally transformed muscle cells that cannot cluster acetylcholine receptors.

1988 • 14 citations

Extracellular synaptic factors induce clustering of acetylcholine receptors stably expressed in fibroblasts.

1991 • 11 citations