Immunosuppression Enhances Oncolytic Adenovirus Replication and Antitumor Efficacy in the Syrian Hamster Model

The adenovirus death protein (E3-11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells

1996 • 370 citations

Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses

1999 • 337 citations

Real-Time Quantitative PCR Assays for Detection andMonitoring of Pathogenic Human Viruses in ImmunosuppressedPediatricPatients

2004 • 317 citations

Viral gene therapy strategies: from basic science to clinical application

2005 • 312 citations

Phase II Trial of CHOP Chemotherapy Followed by Tositumomab/Iodine I-131 Tositumomab for Previously Untreated Follicular Non-Hodgkin's Lymphoma: Five-Year Follow-Up of Southwest Oncology Group Protocol S9911

2006 • 285 citations

The E3-11.6-kDa Adenovirus Death Protein (ADP) Is Required for Efficient Cell Death: Characterization of Cells Infected withadpMutants

1996 • 223 citations

FUNCTIONS AND MECHANISMS OF ACTION OF THE ADENOVIRUS E3 PROTEINS

2004 • 190 citations

Syrian Hamster as a Permissive Immunocompetent Animal Model for the Study of Oncolytic Adenovirus Vectors

2006 • 163 citations

Cyclophosphamide Diminishes Inflammation and Prolongs Transgene Expression Following Delivery of Adenoviral Vectors to Mouse Liver and Lung

1996 • 161 citations

Complement Depletion Facilitates the Infection of Multiple Brain Tumors by an Intravascular, Replication-Conditional Herpes Simplex Virus Mutant

2000 • 151 citations

Immune Reconstitution and Clearance of Human Adenovirus Viremia in Pediatric Stem‐Cell Recipients

2005 • 141 citations

Improved outcome for children with disseminated adenoviral infection following allogeneic stem cell transplantation

2005 • 136 citations

Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector.

1996 • 127 citations

Oncolytic viral therapies

2004 • 126 citations

Tolerance induction in clinical transplantation

2004 • 122 citations

Intratumoral Spread of Wild-Type Adenovirus Is Limited After Local Injection of Human Xenograft Tumors: Virus Persists and Spreads Systemically at Late Time Points

2003 • 122 citations

Overexpression of the ADP (E3-11.6K) Protein Increases Cell Lysis and Spread of Adenovirus

2003 • 121 citations

Adenovirus Methods and Protocols

2007 • 115 citations

Cyclophosphamide decreases the number, percentage and the function of CD25+ CD4+ regulatory T cells, which suppress induction of contact hypersensitivity

2005 • 107 citations

Prolonged clinical benefit with metronomic chemotherapy in patients with metastatic breast cancer

2006 • 102 citations

Wild-Type Adenovirus Decreases Tumor Xenograft Growth, but Despite Viral Persistence Complete Tumor Responses Are Rarely Achieved—Deletion of the Viral E1b-19-kD Gene Increases the Viral Oncolytic Effect

2001 • 97 citations

Quantitative Adenovirus Neutralization Assays Based on the Secreted Alkaline Phosphatase Reporter Gene: Application in Epidemiologic Studies and in the Design of Adenovector Vaccines

2004 • 83 citations

Effect of Adenovirus-Mediated Heat Shock Protein Expression and Oncolysis in Combination with Low-Dose Cyclophosphamide Treatment on Antitumor Immune Responses

2006 • 82 citations

Busulfan-cyclophosphamide versus total body irradiation–cyclophosphamide as preparative regimen before allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia: What have we learned?

2003 • 78 citations

Experimental infections of humans with wild-type adenoviruses and with replication-competent adenovirus vectors: replication, safety, and transmission

2004 • 78 citations

Prostate Cancer Gene Therapy Clinical Trials

2007 • 74 citations

Suppression of the immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide

1998 • 71 citations

Cyclophosphamide Allows for In vivo Dose Reduction of a Potent Oncolytic Virus

2005 • 69 citations

Oncolytic Virotherapy: Approaches to Tumor Targeting and Enhancing Antitumor Effects

2005 • 66 citations

Neuroinvasive properties of herpes simplex virus type 1 glycoprotein variants are controlled by the immune response.

1996 • 61 citations

Adenovirus infection in children after allogeneic stem cell transplantation: diagnosis, treatment and immunity

2005 • 57 citations

Use of the Syrian Hamster as an Animal Model for Oncolytic Adenovirus Vectors

2007 • 52 citations

An Oncolytic Adenovirus Vector Combining Enhanced Cell-to-Cell Spreading, Mediated by the ADP Cytolytic Protein, with Selective Replication in Cancer Cells with Deregulated Wnt Signaling

2004 • 52 citations

Efficacy of Severe Acute Respiratory Syndrome Vaccine Based on a Nonhuman Primate Adenovirus in the Presence of Immunity Against Human Adenovirus

2006 • 51 citations

Immunosuppression promotes reovirus therapy of colorectal liver metastases

2006 • 48 citations

Adenoviral Strategies for the Gene Therapy of Cancer

2005 • 34 citations

Oncolytic adenoviruses as antiglioma agents

2006 • 28 citations

Immune Transfer Protects Severely Immunosuppressed Mice from Murine Cytomegalovirus Retinitis and Reduces the Viral Load in Ocular Tissue

2000 • 21 citations

Relationships between resistance to cross-linking agents and glutathione metabolism, aldehyde dehydrogenase isozymes and adenovirus replication in human tumour cell lines

1990 • 18 citations

Studies of pulmonary and renal immunopathology after nonlethal primary sendai viral infection in normal and cyclophosphamide-treated hamsters.

1977 • 13 citations

Comparison of peripheral blood progenitor cell yield from standard chemotherapy used in the treatment of lymphoid malignancies and high‐dose cyclophosphamide: a retrospective review of 141 patients

2005 • 7 citations

Reduced-intensity transplantation for lymphoma

2006 • 4 citations

Tolerability and safety of classic cyclophosphamide, methotrexate, and fluorouracil treatment in japanese patients with early Breast Cancer

2006 • 4 citations

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