4 Pathogenic mechanisms

UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION

1984 • 5,344 citations

Attachment of Helicobacter pylori to Human Gastric Epithelium Mediated by Blood Group Antigens

1993 • 1,172 citations

The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori

1993 • 793 citations

Purification and characterization of the vacuolating toxin from Helicobacter pylori.

1992 • 700 citations

Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production

1993 • 671 citations

Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology

1991 • 667 citations

Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation

1992 • 619 citations

Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin

1995 • 594 citations

Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis.

1991 • 546 citations

Mucosal Tumor Necrosis Factor-or, Interleukin-1/3, and Interleukin-8 Production in Patients with Helicobacter pylori Infection

1994 • 526 citations

Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications.

1993 • 518 citations

Reactive oxygen species in tumorigenesis.

1994 • 479 citations

The Blood Groups in Relation to Peptic Ulceration and Carcinoma of Colon, Rectum, Breast, and Bronchus

1954 • 428 citations

Shuttle cloning and nucleotide sequences of Helicobacter pylori genes responsible for urease activity

1991 • 419 citations

Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only

1989 • 407 citations

Gastric lymphoid follicles in Helicobacter pylori infection: Frequency, distribution, and response to triple therapy

1993 • 406 citations

Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect of acid

1990 • 400 citations

Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa.

1994 • 349 citations

Progress in Medical Genetics.

1983 • 347 citations

Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole.

1995 • 343 citations

Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa

1991 • 325 citations

Campylobacter pylori and duodenal ulcers: The gastrin link

1989 • 318 citations

Bacterial adhesion and disease activity in Helicobacter associated chronic gastritis.

1990 • 302 citations

Systemic and local antibody responses to gastric Campylobacter pyloridis in non-ulcer dyspepsia.

1986 • 301 citations

Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease

1992 • 299 citations

Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism.

1991 • 296 citations

Mechanisms involved in Helicobacter pylori—Induced inflammation

1993 • 270 citations

Eradicating Helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer.

1993 • 269 citations

Iatrogenic Campylobacter pylori infection is a cause of epidemic achlorhydria.

1988 • 266 citations

Gastric Interleukin‐8 and IgA IL‐8 Autoantibodies in Helicobacter pylori Infection

1993 • 262 citations

Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications

1993 • 245 citations

Low biological activity of Helicobacter pylori lipopolysaccharide

1992 • 244 citations

ABO Blood Groups and Secretor Character in Duodenal Ulcer

1956 • 230 citations

Systemic and mucosal humoral responses to Helicobacter pylori in gastric cancer.

1993 • 223 citations

Helicobacter pylori

1995 • 219 citations

Cloning, nucleotide sequence, and expression of a gene encoding an adhesin subunit protein of Helicobacter pylori

1993 • 210 citations

pH of the microclimate lining human gastric and duodenal mucosa in vivo

1987 • 198 citations

Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury

1992 • 197 citations

Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils.

1992 • 184 citations

Acid secretion and sensitivity to gastrin in patients with duodenal ulcer: effect of eradication of Helicobacter pylori.

1993 • 180 citations

EFFECT OF A CAMPYLOBACTER PYLORI PROTEIN ON ACID SECRETION BY PARIETAL CELLS

1989 • 172 citations

Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria.

1988 • 167 citations

DUODENAL ULCER, CAMPYLOBACTER PYLORI, AND THE "LEAKING ROOF" CONCEPT

1988 • 166 citations

Helicobacter pylori causes hyperproliferation of the gastric epithelium: pre- and post-eradication indices of proliferating cell nuclear antigen.

1993 • 159 citations

Potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of Helicobacter pylori: unique action selective for H. pylori cells

1993 • 158 citations

Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations.

1993 • 155 citations

Neutrophil activation by Helicobacter pylori.

1991 • 155 citations

Interaction between oxygen radicals and gastric mucin

1987 • 153 citations

Helicobacter pylori infection in pernicious anemia: A prospective controlled study

1991 • 143 citations

Helicobacter pylori and peptic ulcers: the present position.

1992 • 142 citations

Incidence of Helicobacter pylori strains activating neutrophils in patients with peptic ulcer disease.

1993 • 141 citations

Relationship between Infective Load of Helicobacter pylori and Reactive Oxygen Metabolite Production in Antral Mucosa

1994 • 136 citations

Helicobacter pylori. Basic Mechanisms to Clinical Cure 1996.

1997 • 133 citations

Helicobacter pylori catalase

1991 • 132 citations

Potentiation of Helicobacter pylori Vacuolating Toxin Activity by Nicotine and Other Weak Bases

1992 • 118 citations

The Hsp60 protein of Helicobacter pylori: structure and immune response in patients with gastroduodenal diseases

1993 • 116 citations

Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach

1992 • 114 citations

Diet and Gastric Cancer: Nutrition Survey in a High-Risk Area<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1983 • 113 citations

Effects of Eradication ofHelicobacter pylorion Gastritis in Duodenal Ulcer Patients

1994 • 108 citations

Effects of ATPase inhibitors on the response of HeLa cells to Helicobacter pylori vacuolating toxin

1993 • 98 citations

Activation of human phagocyte oxidative metabolism by Helicobacter pylori

1992 • 97 citations

Specific and Nonspecific Humoral Defense Factors-in the Epithelium of Normal and Inflamed Gastric Mucosa

1984 • 95 citations

Gamma delta T cell receptor-positive cells of the human gastrointestinal mucosa: occurrence and V region gene expression in Heliobacter pylori-associated gastritis, coeliac disease and inflammatory bowel disease.

1991 • 92 citations

Further evidence of the toxic effect of ammonia produced by Helicobacter pylori urease on human epithelial cells

1992 • 91 citations

Detailed comparison of basal and food-stimulated gastric acid secretion rates and serum gastrin concentrations in duodenal ulcer patients and normal subjects.

1987 • 91 citations

Central action of recombinant interleukin-1 to inhibit acid secretion in rats

1990 • 88 citations

Mechanism of Helcobacter pylori Pathogenesis

1992 • 87 citations

Paf-acether synthesis by Helicobacter pylori.

1990 • 87 citations

Experimental evidence for inhibition of N-nitroso compound formation as a factor in the negative correlation between vitamin C consumption and the incidence of certain cancers.

1994 • 87 citations

Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17.

1993 • 82 citations

Similar acid stimulatory potencies of synthetic human big and little gastrins in man.

1984 • 81 citations

Severity ofHelicobacter-induced gastric injury correlates with gastric juice ammonia

1991 • 77 citations

Receptor affinity purification of a lipid-binding adhesin from Helicobacter pylori

1993 • 77 citations

Helicobacter mustelae and Helicobacter pylori bind to common lipid receptors in vitro

1993 • 73 citations

Effect of inhibition of Helicobacter pylori urease activity by acetohydroxamic acid on serum gastrin in duodenal ulcer subjects.

1991 • 72 citations

Mucosal humoral immune response toHelicobacter pylori in patients with duodenitis

1991 • 72 citations

Cell kinetics of mucosal atrophy in rat stomach induced by long-term administration of ammonia

1993 • 70 citations

Ascorbic acid and the formation of N-nitroso compounds: possible role of ascorbic acid in cancer prevention

1987 • 70 citations

Effect of vagus, gastric inhibitory polypeptide, and HCl on gastrin and somatostatin release from perfused pig antrum

1983 • 69 citations

Contact of lymphocytes with Helicobacter pylori augments natural killer cell activity and induces production of gamma interferon

1993 • 69 citations

Regulation of rat antral gastrin and somatostatin gene expression during starvation and after refeeding

1991 • 69 citations

Helicobacter pylori associated phospholipase A2 activity: a factor in peptic ulcer production?

1992 • 67 citations

Surface hydrophobicity of gastric mucosa in Helicobacter pylori infection: Effect of clearance and eradication

1992 • 67 citations

Rapid fingerprinting of Helicobacter pylori by polymerase chain reaction and restriction fragment length polymorphism analysis

1993 • 66 citations

Eosinophil infiltration and degranulation inHelicobacter pylori-associated chronic gastritis

1991 • 65 citations

An increased number of gamma/delta T-cells and gastric epithelial cell expression of the groEL stress-protein homologue in Helicobacter pylori-associated chronic gastritis of the antrum.

1991 • 64 citations

Expression of catalytically active recombinant Helicobacter pylori urease at wild-type levels in Escherichia coli

1993 • 61 citations

Ammonia: a possible promotor in Helicobacter pylori-related gastric carcinogenesis

1992 • 60 citations

Evidence for Gastric Mucosal Cell Invasion by C. pylori

1990 • 60 citations

Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients.

1992 • 58 citations

Gastroduodenal mucus gel thickness in patients with Helicobacter pylori: a method for assessment of biopsy specimens.

1991 • 58 citations

Natural History of Gastritis and its Relationship to Peptic Ulcer Disease

1992 • 58 citations

Comparison of labelling by bromodeoxyuridine, MIB-1, and proliferating cell nuclear antigen in gastric mucosal biopsy specimens.

1994 • 57 citations

Progress in Medical Genetics

1966 • 56 citations

Gastric pepsin and acid secretion in patients with acute and healed duodenal ulcer

1981 • 56 citations

The Secretory Kinetics of the G Cell in Omeprazole-Treated Rats

1991 • 56 citations

Bombesin/GRP-stimulated somatostatin secretion is mediated by gastrin in the antrum and intrinsic neurons in the fundus

1991 • 55 citations

The adherent gastric mucus gel barrier in man and changes in peptic ulceration

1990 • 54 citations

Opsonic Activity of Specific Human IgG against Helicobacter pylori

1990 • 52 citations

Potent Inhibition of Gastric Acid Secretion and Ulcer Formation by Centrally and Peripherally Administered Interleukin‐1a

1992 • 49 citations

Role of luminal ammonia in the development of gastropathy and hypergastrinemia in the rat

1995 • 48 citations

Association of Helicobacter pylori with HLA-DR antigen expression in gastritis.

1992 • 45 citations

Helicobacter pylori-associated exaggerated gastrin release in duodenal ulcer patients

1991 • 41 citations

Molecular forms of gastrin in peptic ulcer: comparison of serum and tissue concentrations of G17 and G34 in gastric and duodenal ulcer subjects

1980 • 41 citations

The Mechanism of Hypergastrinemia in Achlorhydria

1976 • 40 citations

Intestinal intraepithelial lymphocytes and lymphoepithelial interactions in the human gastrointestinal mucosa

1992 • 39 citations

Interferon-gamma and Tumour Necrosis Factor Production in Patients withHelicobacter pylori Infection

1993 • 36 citations

Gastric Carcinoma: Failed Adaptation to Helicobacter pylori

1992 • 32 citations

Identification of erythrocyte-binding antigens in Helicobacter pylori

1992 • 31 citations

A neutrophil chemotactic factor present inH. pylori but absent inH. mustelae

1993 • 27 citations

Interaction of Helicobacter pylori (Strain 151) and Campylobacter coli with human peripheral polymorphonuclear granulocytes

1993 • 27 citations

Role of ammonia in the pathogenesis of the gastritis, hypergastrinaemia, and hyperpepsinogenaemia I caused by Helicobacter pylori infection.

1992 • 25 citations

Helicobacter pylori increases gastric antral juxtamucosal pH

1993 • 25 citations

Influence of inflammation and atrophy on pancreatic secretory trypsin inhibitor levels within the gastric mucosa

1994 • 22 citations

The genetics of peptic ulcer: more than one gene, more than one disease.

1980 • 22 citations

Inhibition of pentagastrin-stimulated gastric acid secretion by graded intraduodenal administration of oleic acid in man.

1981 • 21 citations

Role of ischaemia in the initiation of peptic ulcer.

1977 • 21 citations

Helicobacter pylori and duodenal ulcer disease: The somatostatin link?

1993 • 19 citations

Use of an Ammonia Electrode for Rapid Quantification of <i>Helicobacter pylori</i> Urease: Its Use in the Endoscopy Room and in the Assessment of Urease Inhibition by Bismuth Subsalicylate

1992 • 15 citations

Helicobacter pylori Infection

1994 • 14 citations

Defective Inhibition of Gastrin Release by Antral Distension in Duodenal Ulcer Patients

1992 • 12 citations

Duodenogastric Bile Reflux in Patients with Gastric Ulcer

1984 • 9 citations

HELICOBACTER-PYLORI RAISES THE PH IN THE JUXTAEPITHELIAL REGION OF THE MUCUS LAYER OF THE GASTRIC ANTRUM AND BODY

1991 • 5 citations

Adherence of haemagglutinating Helicobacter pylori to five cell lines

1993 • 4 citations

T cell subsets in H. pylori-associated gastritis

1994 • 3 citations

Benign gastric ulcers and pernicious anemia.

1990 • 2 citations

[Effect of a long-term oral ammonia administration on immunoreactive-somatostatin concentrations of rat stomach].

1992 • 2 citations

Chronic gastritis and gastric ulcer.

1970 • 1 citations