Localization of nucleolar chromatin by immunocytochemistry and in situ hybridization at the electron microscopic level

Monoclonal Antibody to 5-Bromo- and 5-Iododeoxyuridine: A New Reagent for Detection of DNA Replication

1982 • 2,648 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Principles and Techniques of Electron Microscopy

1981 • 1,469 citations

A new method of preparing gold probes for multiple-labeling cytochemistry.

1985 • 1,417 citations

Structure of Chromatin

1977 • 1,276 citations

FORMATION AND DETECTION OF RNA-DNA HYBRID MOLECULES IN CYTOLOGICAL PREPARATIONS

1969 • 1,214 citations

Practical Methods in Electron Microscopy

1973 • 983 citations

Autoantibodies to Nuclear Antigens (ANA): Their Immunobiology and Medicine

1982 • 975 citations

Nucleosome Structure

1980 • 923 citations

Visualization of Nucleolar Genes

1969 • 865 citations

Immunological method for mapping genes on Drosophila polytene chromosomes.

1982 • 772 citations

Immunochemistry on ultrathin frozen sections

1980 • 755 citations

Enhancement of structural preservation and immunocytochemical staining in low temperature embedded pancreatic tissue.

1981 • 721 citations

Resin development for electron microscopy and an analysis of embedding at low temperature*

1982 • 714 citations

RNA-DNA Hybrids at the Cytological Level

1969 • 592 citations

Sizing of protein A-colloidal gold probes for immunoelectron microscopy.

1981 • 573 citations

The Nucleolus and Ribosome Biogenesis

1985 • 531 citations

Application of cryoultramicrotomy to immunocytochemistry

1986 • 516 citations

Protein A‐gold electron microscopic immunocytochemistry: Methods, applications, and limitations

1984 • 493 citations

Quantitative Methods in Biology

1978 • 409 citations

The Nucleolar Structure

1976 • 370 citations

Profiles of Antinuclear Antibodies in Systemic Rheumatic Diseases

1975 • 365 citations

Transcriptionally active chromatin

1984 • 361 citations

Nucleolar Structure

1984 • 333 citations

A study of positive staining of ultrathin frozen sections

1978 • 329 citations

Localization of RNA polymerase I in interphase cells and mitotic chromosomes by light and electron microscopic immunocytochemistry.

1984 • 313 citations

A simple post-embedding system for the rapid demonstration of tissue antigens under the electron microscope

1983 • 299 citations

Effect of tissue processing on colloidal gold cytochemistry.

1987 • 298 citations

Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

1988 • 282 citations

Functional and dynamic aspects of the mammalian nucleolus

1990 • 276 citations

Antinuclear antibodies (ANAs): Diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity

1988 • 274 citations

Rapid embedding of tissues in Lowicryl K4M for immunoelectron microscopy.

1984 • 266 citations

Autoantibody to RNA polymerase I in scleroderma sera.

1987 • 241 citations

Specimen preparation for electron microscopy using low temperature embedding resins

1982 • 240 citations

Reversible changes in nucleosome structure and histone H3 accessibility in transcriptionally active and inactive states of rDNA chromatin

1983 • 231 citations

Colloidal Gold Probes in Immunocytochemistry

1983 • 206 citations

EVALUATION OF COLLOIDAL GOLD AS A CYTOCHEMICAL MARKER FOR TRANSMISSION AND SCANNING ELECTRON MICROSCOPY

1979 • 196 citations

A subthreshold level of DNA topoisomerases leads to the excision of yeast rDNA as extrachromosomal rings

1989 • 193 citations

Resolution and limitations of the immunoperoxidase procedure in the localization of extracellular matrix antigens.

1983 • 192 citations

The efficiency of immunolabel on Lowicryl sections compared to theoretical predictions.

1987 • 189 citations

Modern acrylics for post-embedding immunostaining techniques.

1987 • 171 citations

Low temperature embedding with Lowicryl resins: two new formulations and some applications

1985 • 170 citations

The preparation of protein A-gold complexes with 3 nm and 15 nm gold particles and their use in labelling multiple antigens on ultra-thin sections

1982 • 168 citations

Techniques in immunocytochemistry, vol. 1

1983 • 165 citations

In situ hybridization at the electron microscope level: localization of transcripts on ultrathin sections of Lowicryl K4M-embedded tissue using biotinylated probes and protein A-gold complexes.

1986 • 164 citations

Antibodies to Native and Denatured Deoxyribonucleic Acid in Systemic Lupus Erythematosus*

1967 • 159 citations

The Specificity and Applications of Antibodies to Helical Nucleic Acid

1975 • 143 citations

Detection of 5-bromodeoxyuridine (BrdUrd) incorporation by monoclonal antibodies: role of the DNA denaturation step.

1985 • 136 citations

In situ hybridization at the electron microscope level: hybrid detection by autoradiography and colloidal gold

1982 • 134 citations

Scl 70 autoantibodies from scleroderma patients recognize a 95 kDa protein identified as DNA topoisomerase I

1986 • 133 citations

On the position of nucleolus organizer regions (NORs) in interphase nuclei

1986 • 129 citations

Human autoantibodies: probes for nucleolus structure and function

1987 • 128 citations

The Nucleolus and Nucleolar DNA

1974 • 127 citations

In situ hybridization at the electron microscope level: an improved method for precise localization of ribosomal DNA and RNA.

1989 • 119 citations

Enzymes of Nucleic Acid Synthesis and Modification

2018 • 116 citations

Association of DNA topoisomerase I and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcription

1988 • 113 citations

Inhibition of nucleolar reformation after microinjection of antibodies to RNA polymerase I into mitotic cells.

1987 • 110 citations

The nucleolus, chromosomes, and visualization of genetic activity.

1981 • 110 citations

Does the synthesis of ribosomal RNA take place‐within nucleolar fibrillar centers or dense fibrillar components?

1989 • 110 citations

High resolution autoradiographic studies of Ehrlich tumour cell nucleoli

1976 • 96 citations

Protein kinase activity of RNA polymerase I purified from a rat hepatoma: probable function of Mr 42,000 and 24,600 polypeptides.

1981 • 93 citations

Localization of ribosomal protein S1 in the granular component of the interphase nucleolus and its distribution during mitosis.

1985 • 90 citations

Molecular Hybridization of DNA and RNA in Situ

1973 • 88 citations

Developments of new Lowicryl® resins for embedding biological specimens at even lower temperatures

1986 • 87 citations

High sensitivity immunolocalization of double and single-stranded DNA by a monoclonal antibody.

1987 • 85 citations

Role of DNA topoisomerase I in the transcription of supercoiled rRNA gene.

1987 • 83 citations

THE PRESERVATION OF ULTRASTRUCTURE AND ANTIGENICITY

1982 • 80 citations

A recognition site on synthetic helical oligonucleotides for monoclonal anti-native DNA autoantibody.

1986 • 79 citations

Denaturation, renaturation, and loss of DNA during in situ hybridization procedures

1986 • 79 citations

LR white resin and improved on-grid immunogold detection of vicilin, a pea seed storage protein

1984 • 78 citations

Dehydration and embedding temperatures affect the antigenic specificity of tubulin and immunolabeling by the protein A-colloidal gold technique.

1983 • 74 citations

Structural support for RNA synthesis in the cell nucleus.

1986 • 73 citations

Identification and localization of a novel nucleolar protein of high molecular weight by a monoclonal antibody

1984 • 70 citations

Ribosomal DNA is located and transcribed in the dense fibrillar component of human Sertoli cell nucleoli

1989 • 68 citations

Three-dimensional organization of ribosomal DNA in interphase nuclei ofPisum sativum by in situ hybridization and optical tomography

1990 • 67 citations

Nucleologenesis: use of non‐isotopic in situ hybridization and immunocytochemistry to compare the localization of rDNA and nucleolar proteins during mitosis

1989 • 67 citations

Does the synthesis of ribosomal RNA take place-within nucleolar fibrillar centers or dense fibrillar components?

1989 • 66 citations

Localization of DNA within Ehrlich tumour cell nucleoli by immunoelectron microscopy

1988 • 63 citations

Effect of particle size on labeling density for catalase in protein A-gold immunocytochemistry.

1988 • 62 citations

Altered nucleosomes of active nucleolar chromatin contain accessible histone H3 in its hyperacetylated forms.

1987 • 60 citations

Immunolocalization of DNA at nucleolar structural components in onion cells

1989 • 55 citations

Antibodies to double-stranded DNA: purification and characterization of binding specificities.

1980 • 51 citations

Correlation of some mechanical properties of embedding resins with their behaviour in microtomy

1987 • 50 citations

Structural organization of mouse rDNA: Comparison of transcribed and non-transcribed regions

1980 • 45 citations

Immunoelectron microscope localization of bromodeoxyuridine incorporated into DNA of Ehrlich tumor cell nucleoli

1988 • 43 citations

Re‐evaluation of the site of transcription in Ehrlich tumour cell nucleoli

1985 • 41 citations

Nucleolar changes after microinjection of antibodies to RNA polymerase I into the nucleus of mammalian cells

1988 • 41 citations

Microinjection of anti-topoisomerase I immunoglobulin G into nuclei of Chironomus tentans salivary gland cells leads to blockage of transcription elongation.

1987 • 40 citations

Immunocytochemical localization of RNA polymerase I in the fibrillar centers of nucleoli

1987 • 40 citations

Metal compound intensification of the electron-density of diaminobenzidine.

1983 • 39 citations

Immunocytochemistry: Its evolution and criteria for its application in the study of epon‐embedded cells and tissue

1986 • 38 citations

Fibrillar center distribution in nucleoli of PHA-stimulated human lymphocytes

1989 • 38 citations

The Use of Multiple Methods to Validate Immunocytochemical Stains

1983 • 36 citations

Anti‐bromodeoxyuridine monoclonal antibody: An alternative tool for the identification of replicated DNA at the electron microscope level

1988 • 35 citations

Immunolabelling for electron microscopy

1985 • 31 citations

Stability of the primary organization of nucleosome core particles upon some conformational transitions

1981 • 27 citations

Structure and Function of Eukaryotic Chromosomes

1987 • 26 citations

Progress in visualization of eukaryotic gene transcription

1983 • 22 citations

Molecular hybridization of mouse satellite DNA-complementary RNA in ultrathin sections prepared for electron microscopy

1974 • 21 citations

Electron-microscopical evidence that ribosomal chromatin of human circulating lymphocytes is devoid of histones

1985 • 18 citations

Contributions of Electron Microscopic Spreading Preparations (“Miller Spreads”) to the Analysis of Chromosome Structure

1987 • 17 citations

Three-dimensional localisation of DNA in the nucleolus of Spirogyra by correlated optical tomography and serial ultra-thin sectioning

1990 • 15 citations

Ultrastructural distribution of histones within Ehrlich tumor cell nucleoli: a cytochemical and immunocytochemical study.

1989 • 14 citations

Kinetic, computer, and electron microscopic studies dealing with an artificial enzyme membrane: theoretical and experimental evaluation of the cytochemical demonstration of acetylcholinesterase.

1981 • 13 citations

Chromosomal DNA denaturation and reassociation in situ

1979 • 13 citations

A new heavy‐metal‐containing resin for low‐temperature embedding and imaging of unstained sections of biological material

1986 • 10 citations

Ultrastructural localization of DNA in tissue culture cell nuclei by means of enzyme-gold and autoimmune sera-protein A-gold techniques

1984 • 9 citations

Fracture—Permeation: A technique to assess cytoplasm compactness after glutaraldehyde‐fixation

1986 • 9 citations

Ultrastructural patterns of ferritin permeation into glutaraldehyde‐fixed freeze‐fractured sarcomeres characterize stages of contraction in striated muscle

1986 • 8 citations

Selection of ehrlich tumor cells in different phases of the cell cycle by ficoll gradient centrifugation

1977 • 6 citations

Organisation ultrastructurale du nucléole au cours du cycle cellulaire. Etude cytochimique, immunocytochimique et par hybridation in situ

1989 • 3 citations