The Nucleolus and Nucleolar DNA

Visualization of Nucleolar Genes

1969 • 865 citations

Specific Gene Amplification in Oocytes

1968 • 811 citations

The Cell in Development and Heredity

1925 • 767 citations

Cell Growth and Cell Function.

1950 • 640 citations

Location of Ribosomal DNA in the Human Chromosome Complement

1972 • 554 citations

RNA synthesis during the development of Xenopus laevis, the South African clawed toad

1964 • 528 citations

A comparison of the ribosomal DNA's of Xenopus laevis and Xenopus mulleri: the evolution of tandem genes

1972 • 428 citations

Ribosomal cistrons and the nucleolar organizer

1966 • 397 citations

Differential synthesis of the genes for ribosomal RNA during amphibian oögenesis.

1968 • 386 citations

Gene linkage by RNA-DNA hybridization

1968 • 384 citations

The lac operator is DNA.

1967 • 303 citations

ISOLATION OF THE λ PHAGE REPRESSOR

1967 • 285 citations

The fine structure of the cancer cell nucleus

1963 • 277 citations

Differential Uptake of Tritiated Thymidine into Hetero- and Euchromatin in Melanoplus and Secale

1959 • 274 citations

Composition and structure of chromosomal and amplified ribosomal DNA's of Xenopus laevis

1970 • 269 citations

Properties and Composition of the Isolated Ribosomal DNA Satellite of Xenopus laevis

1968 • 269 citations

Comparison of Nucleolar Proteins of Normal Rat Liver and Novikoff Hepatoma Ascites Cells by Two-Dimensional Polyacrylamide Gel Electrophoresis

1973 • 260 citations

Specific Binding of the λ Phage Repressor to λ DNA

1967 • 254 citations

Cytochimie ultrastructurale du nucléole

1965 • 248 citations

Oogenesis: The Storage of Developmental Information

1962 • 242 citations

Localisation of rapidly and slowly labelled nuclear RNA as visualized by high resolution autoradiography

1971 • 233 citations

CHLOROPLAST DNA IN CHLAMYDOMONAS

1963 • 225 citations

Low molecular weight RNA associated with 28 s nucleolar RNA

1970 • 198 citations

THE FINE STRUCTURE OF THE DNP COMPONENT OF THE NUCLEUS

1963 • 190 citations

Comparative cytological studies, with especial regard to the morphology of the nucleolus

1898 • 179 citations

Retention of common nucleotide sequences in the ribosomal deoxyribonucleic acid of eukaryotes and some of their physical characteristics

1971 • 164 citations

Increasing the Multiplicity of Ribosomal RNA Genes in Drosophila melanogaster

1971 • 164 citations

Some Parallels Between Gene Control Systems in Maize and in Bacteria

1961 • 163 citations

A HEAT-SENSITIVE CELLULAR FUNCTION LOCATED IN THE NUCLEOLUS

1967 • 161 citations

Cytochemical studies on nuclear fine structure*1

1963 • 159 citations

Isolation of Preribosomes from HeLa Cells and Their Characterization by Electrophoresis on Uniform and Exponential‐Gradient‐Polyacrylamide Gels

1971 • 155 citations

THE RELATIONSHIP OF THE NUCLEOLUS TO THE SYNTHESIS OF RIBOSOMAL RNA IN HELA CELLS

1964 • 151 citations

Cytochimie ultrastructurale du nucléole — RNA et protéines intranucléolaires

1964 • 150 citations

Reduced Polyteny of Ribosomal RNA Cistrons in Giant Chromosomes of Drosophila hydei*

1971 • 148 citations

ELECTRON MICROSCOPIC EXAMINATION OF THE SITES OF NUCLEAR RNA SYNTHESIS DURING AMPHIBIAN EMBRYOGENESIS

1965 • 147 citations

Chromosomes and Nucleoli of the Axolotl, Ambystoma Mexicanum

1966 • 145 citations

THE RELATIONSHIP BETWEEN RNA SYNTHESIS AND LOOP STRUCTURE IN LAMPBRUSH CHROMOSOMES

1963 • 145 citations

Gene Amplification in the Oocyte Nucleus of Mutant and Wild-type Xenopus laevis

1968 • 139 citations

Gene amplification in the oocytes of dytiscid water beetles

1969 • 130 citations

Ribosomal RNA Genes and Plant Development

1972 • 128 citations

THE NUCLEOLAR CHANNEL SYSTEM OF HUMAN ENDOMETRIUM

1965 • 122 citations

The fine structure of a nucleolar constituent

1969 • 120 citations

EXTRUSION OF NUCLEOLI FROM PRONUCLEI OF THE RAT

1965 • 119 citations

Characterization of ribosomal precursor particles from HeLa cell nucleoli

1972 • 115 citations

RIBOSOME PRECURSOR PARTICLES IN NUCLEOLI

1969 • 114 citations

A light- and electron-microscope study of the nucleolus during growth of the oocyte in the prepubertal mouse

1971 • 111 citations

The Nucleus: Action of Chemical and Physical Agents

1970 • 104 citations

Denaturation map of the ribosomal DNA of Xenopus laevis

1971 • 102 citations

Cortisone Stimulation of Nucleolar RNA Polymerase Activity

1971 • 101 citations

The Rapid Turnover of RNA Polymerase of Rat Liver Nucleolus, and of Its Messenger RNA

1972 • 101 citations

Portrait of a gene

1969 • 99 citations

THE FINE STRUCTURE OF THE NUCLEOLUS DURING MITOSIS IN THE GRASSHOPPER NEUROBLAST CELL

1965 • 98 citations

Gene amplification proceeds by a chromosome copy mechanism

1972 • 97 citations

THE BASE COMPOSITION OF RIBONUCLEIC ACID IN LAMPBRUSH CHROMOSOMES, NUCLEOLI, NUCLEAR SAP, AND CYTOPLASM OF TRITURUS OOCYTES

1963 • 94 citations

Isolation of deoxyribonucleic acid from mitochondria of chick embryo heart and liver.

1965 • 92 citations

A new structure observed in the nucleolus of the human endometrial epithelial cell

1963 • 90 citations

Regulation of ribosomal RNA synthesis and its bearing on the bobbed phenotype in Drosophila melanogaster

1970 • 90 citations

Nucleolar dna in oocytes of Xenopus Laevis

1968 • 89 citations

Histones and Other Nuclear Proteins.

1966 • 86 citations

THE FINE STRUCTURE OF THE NUCLEOLUS IN MITOTIC DIVISIONS OF CHINESE HAMSTER CELLS IN VITRO

1965 • 85 citations

SPHEROIDAL AND RING NUCLEOLI IN AMPHIBIAN OOCYTES

1967 • 85 citations

Investigations on the ultrastructural changes of the spinal ganglion neurons in the course of axon regeneration and cell hypertrophy

1963 • 82 citations

Nucleic Acid Storage in the Toad's Egg

1942 • 81 citations

THE NUCLEOLUS AND ITS GENES IN AMPHIBIAN OOGENESIS

1972 • 80 citations

Studies of mouse liver necrosis in vitro. Ultrastructural and cytochemical alterations in hepatic parenchymal cell nuclei.

1965 • 80 citations

Zur Struktur des Nucleolus und des Kernes

1957 • 80 citations

ULTRASTRUCTURAL ASPECTS OF NUCLEO-CYTOPLASMIC RELATIONSHIP

1958 • 80 citations

Reduction of ribosomal RNA synthesis and ribosomal RNA genes in a mutant of Xenopus laevis which organizes only a partial nucleolus

1970 • 78 citations

THE DISORGANIZATION OF HEPATIC CELL NUCLEOLI INDUCED BY ETHIONINE AND ITS REVERSAL BY ADENINE

1968 • 76 citations

An electron microscope study of differentiation and growth in oocytes of Ophioderma panamensis

1968 • 76 citations

A STUDY OF THE NUCLEOLAR MATERIAL IN SCIARA COPROPHILA

1966 • 75 citations

Changes in nucleolar ultrastructure associated with differentiation in the root tip

1967 • 75 citations

Ribosomal genes of Physarum: Their isolation and replication in the mitotic cycle

1972 • 75 citations

Hybridization of plant ribosomal RNA to DNA: the isolation of a DNA component rich in ribosomal RNA cistrons.

1967 • 73 citations

Chemistry and Brain Development

1972 • 68 citations

The oögenesis of bufo lentiginosus

1908 • 68 citations

Low-Molecular-Weight Nuclear RNAs

1971 • 68 citations

Localization and characterization of the ribosomal RNA cistrons in Sciara coprophila

1971 • 67 citations

Présence dans le nucléole de deux types de ribonucléoprotéines morphologiquement distinctes

1963 • 66 citations

Über totale und partielle somatische Heteropyknose, sowie strukturelle Geschlechtschromosomen bei Drosophila funebris

1933 • 66 citations

INTRANUCLEOLAR MEMBRANES AND NUCLEAR-CYTOPLASMIC EXCHANGE IN YOUNG CRAYFISH OOCYTES

1968 • 64 citations

Nucleic Acid Synthetic Patterns in Synchronized Mammalian Cells

1966 • 64 citations

The role of the nucleolus in the formation of ribosomes

1965 • 62 citations

Light- and electron microscope studies on the spleen of the newtTriturus cristatus:The fine structure of erythropoietic cells

1967 • 62 citations

Activation of nucleoli in tuber slices and the function of nucleolar vacuoles

1972 • 61 citations

A STUDY OF NUCLEOLAR VACUOLES IN CULTURED TOBACCO CELLS USING RADIOAUTOGRAPHY, ACTINOMYCIN D, AND ELECTRON MICROSCOPY

1969 • 61 citations

Morphologic variations in human leukemic lymphoblasts (CCRF-CEM cells) after long-term culture and exposure to chemotherapeutic agents:A study with the electron microscope

1966 • 60 citations

Structural Analysis of Nucleolar Precursors of Ribosomal Ribonucleic Acid

1970 • 59 citations

Die Oogenese der Tipuliden

1955 • 58 citations

A reevaluation of nuclear and nucleolar changes induced in vitro by actinomycin D.

1971 • 57 citations

The Nucleolus Problem.

1957 • 57 citations

The First Steps of Magnification of DNA Complementary to Ribosomal RNA in Drosophila melanogaster

1971 • 56 citations

The Relation of the Structure of Progestational Steroids to Nucleolar Differentiation in Human Endometrium

1972 • 55 citations

Transcriptional mapping of ribosomal RNA genes of the chloroplast and nucleus of Chlamydomonas reinhardi

1971 • 55 citations

Ribosome Assembly in Hela Cells

1972 • 52 citations

Zum Nucleolus-Problem

1957 • 52 citations

Evolution of the nucleoli during oogenesis in Xenopus laevis studied by electron microscopy

1972 • 51 citations

Asynchronous replication of the mouse sex chromosomes

1965 • 51 citations

The Value of the Macronucleolus in the Cancer Problem

1936 • 50 citations

Two-dimensional polyacrylamide gel electrophoresis of acid extractable nuclear proteins of normal rat liver and Novikoff hepatoma ascites cells

1973 • 48 citations

Preferential replication of the ribosomal RNA genes during a nutritional shift-up in Tetrahymena pyriformis

1972 • 47 citations

Effects of Aldosterone on RNA Polymerase in Rat Heart and Kidney Nuclei

1972 • 46 citations

An electron microscope study of age changes in the liver of the mouse

1962 • 46 citations

High resolution autoradiographic studies of the uptake of 3H-5-uridine into condensed and dispersed chromatin of nuclei and granular and fibrillar components of nucleoli of Novikoff hepatoma ascites cells

1968 • 46 citations

Further experiments on the role of the nucleolus in the expression of structural genes

1972 • 44 citations

Formation of microspherules in nucleoli of tumor cells treated with high doses of actinomycin D.

1967 • 44 citations

The replication of the minor DNA component of mouse fibroblasts

1963 • 44 citations

In vitro Production of Nucleolar Channel System by Progesterone in Human Endometrium

1970 • 43 citations

The role of lampbrush chromosomes in the formation of nucleoli in amphibian oocytes.

1965 • 43 citations

The sequential stimulation of uracil-rich and guanine-rich RNA species during cortisone induction of hepatic enzymes

1969 • 43 citations

IN VITRO LABELING OF RNA IN ISOLATED NUCLEOLI OF THE WALKER TUMOR AND LIVER.

1964 • 41 citations

[On chromatin cells].

1963 • 41 citations

in vitro processing of HeLa cell preribosomes by a nucleolar endoribonuclease

1972 • 41 citations

Nuclear pockets associated with the nucleolus in normal and neoplastic cells.

1971 • 40 citations

STUDIES ON THE ULTRASTRUCTURE OF THE NUCLEOLI OF THE WALKER TUMOR AND RAT LIVER.

1964 • 40 citations

Pattern of incorporation of [3H]uridine into rna of amphibian oocyte nucleoli

1967 • 39 citations

Has the Cancer Cell any Differential Characteristics?

1934 • 39 citations

�ber Chromatin und DNS-Synthese im Nucleolus

1963 • 38 citations

Chromatin structures in ring-shaped nucleoli of human lymphocytes

1968 • 38 citations

Biochemical and ultrastructural characteristics of ribonucleoprotein particles isolated from rat-liver cell nucleoli

1969 • 37 citations

Compact filamentous bodies of nuclei and nucleoli of human prostate gland

1971 • 37 citations

Studies on the ultrastructure of nucleoli in human smooth muscle cells

1970 • 35 citations

Inhibition of nucleolar RNP synthesis by cycloheximide as studied by high resolution radioautography

1971 • 35 citations

Evidence that the granular and fibrillar components of nucleoli contain 28 and 6S RNA, respectively

1966 • 35 citations

Cytochemistry and fine structure of elimination chromatin in Dytiscidae

1968 • 35 citations

Nonoperative DNA complementary to ribosomal RNA.

1968 • 34 citations

Quantitative analysis of ultrastructural components of nucleoli of the Walker tumor and liver.

1966 • 34 citations

Studies on nucleoli and cytoplasmic fibrillar bodies of human hepatocellular carcinomas.

1972 • 33 citations

INDICATION OF GENE AMPLIFICATION IN RHYNCHOSCIARA BY RNA-DNA HYBRIDIZATION

1971 • 33 citations

Time of duplication of ribosomal RNA cistrons in a cell line of Potorous tridactylis (rat kangaroo)

1972 • 32 citations

Correlation of nucleolini with fine structural nucleolar constituents of cultured normal and neoplastic cells.

1971 • 32 citations

Possible Control of Lymphocyte Growth at the Level of Ribosome Assembly

1968 • 32 citations

A CYTOCHEMICAL AND RADIOAUTOGRAPHIC STUDY OF HUMAN TISSUE CULTURE CELL NUCLEOLI

1970 • 32 citations

REPLICATION OF CHROMATIN IN MOUSE MAMMARY EPITHELIAL CELLS GROWN IN VITRO

1965 • 31 citations

Ring shaped nucleoli in liver cells of rats after treatment with Actinomycin D

1968 • 31 citations

Nuclear, nucleolinar and cytoplasmic acid phosphatases in cultured mammalian cells

1969 • 31 citations

Sites of Synthesis and Processing of Ribosomal RNA Precursors within the Nucleolus of Urechis caupo Eggs

1970 • 30 citations

Purification and properties of a nucleolar endoribonuclease from Novikoff hepatoma

1973 • 30 citations

NUCLEOLI OF DIPLOID CELL STRAINS

1971 • 30 citations

The number and activity of ribosomal RNA genes in Xenopus laevis embryos carrying partial deletions in both nucleolar organizers

1972 • 30 citations

Comparative studies of the nucleoli of Morris hepatomas, embryonic liver, and aflatoxin B1-treated liver of rats.

1967 • 29 citations

The fine structure of the nucleoli of normal and actinomycin D-treated Amoeba proteus

1968 • 29 citations

Light and electron microscopic observations of an intranucleolar body in nerve cells

1963 • 29 citations

Comparative studies on the ultrastructure of nucleoli in human lymphosarcoma cells and leukemic lymphocytes.

1970 • 29 citations

Electron Microscope Study of Human NB and SMH Cells Infected with the Parvovirus, H-1: Involvement of the Nucleolus

1969 • 29 citations

Ultrastructural studies on nucleic acids of nucleolar granular components in Novikoff hepatoma cells

1968 • 29 citations

Ultrastructural studies on RNA and DNA components of isolated nucleoli of walker 256 carcinosarcoma

1966 • 28 citations

Nucleolar structure during the meiotic prophase in Allium cepa anthers

1970 • 28 citations

Replication of autosomal heterochromatin in man

1965 • 27 citations

Studies on nucleoli of leukemic agranulocytes and plasmacytes in multiple myeloma

1966 • 27 citations

A morphologic study on the chromatin areas associated with the nucleolus

1967 • 26 citations

Intranuclear and intranucleolar tubular structures in novikoff hepatoma cells

1969 • 26 citations

A large scale procedure for isolation of nucleoli from rat liver

1965 • 25 citations

An electron microscope study of intranuclear canaliculi in Novikoff hepatoma cells.

1970 • 25 citations

Ultrastructural and biochemical studies on ribonucleoprotein particles from isolated nucleoli of thioacetamide-treated rat liver

1971 • 24 citations

Significance of ring shaped nucleoli and micronucleoli in human lymphocytes.

1969 • 24 citations

On the ultrastructure of nucleoli in human leukemic myeloblasts

1969 • 23 citations

The occurrence of dense granules of unknown function in the nucleoli of certain plant cells

1961 • 23 citations

Studies on nucleoli of maturing frog erythroblasts

1972 • 21 citations

Lead-positive nuclear structures and their behavior under the effect of various drugs

1972 • 21 citations

Dense granules in nucleoli of Walker 256 carcinosarcoma cells of the rat

1965 • 20 citations

Induction of nucleolar segregation by actinomycin D following inhibition of protein synthesis with cycloheximide

1970 • 20 citations

Incorporation of l-[14C]leucine into the nucleoli of mouse ascites tumor cells

1969 • 19 citations

Difference in the proportion of DNA specific to ribosomal RNA between adults and larvae of Drosophila melanogaster

1972 • 19 citations

Morphological studies on ring-shaped nucleoli and micronucleoli in frog erythroblasts

1971 • 19 citations

NUCLEAR AND NUCLEOLAR ULTRASTRUCTURE DURING THE LATE STAGES OF NORMAL HUMAN KERATINOCYTE MATURATION

1972 • 19 citations

Annular nucleolus in hepatocyte of chicken embryo induced by aflatoxin B1

1971 • 18 citations

Electron microscopic studies on HeLa cells exposed to the antibiotic toyocamycin.

1969 • 18 citations

The effect of chromomycin A3 on the formation of ring shaped nucleoli and incorporation of H3 uridine in cell cultures.

1968 • 17 citations

Nucleolar morphology, nucleic acid syntheses, and growth rates of experimental tumors.

1971 • 17 citations

Untersuchungen zur Argentaffinreaktion des Nukleolus

1967 • 17 citations

Selective removal of the perinucleolar nucleolus-associated chromatin from the isolated nucleoli of livers of thioacetamide-treated rats

1968 • 17 citations

Ultrastructural Aspects of Bone Marrow and Peripheral Blood Cells in a Case of Plasma Cell Leukemia

1971 • 17 citations

Non-random Variability in Evolution of Base Compositions of Ribosomal RNA

1969 • 16 citations

Dependence of the nucleolar structure on DNA and RNA synthesis

1972 • 16 citations

ULTRASTRUCTURAL CYTOCHEMISTRY OF THE NUCLEOLUS. RNA AND INTRANUCLEOLAR PROTEINS

1964 • 16 citations

Ultrastructural study of nucleolar alterations produced by a single carcinogenic dose of urethan in mouse hepatocytes.

1972 • 16 citations

Further Observations on the Macronucleolus of Cancer

1937 • 15 citations

In vitro stimulation of RNA synthesis in isolated rat liver nuclei by glucocorticoids

1969 • 13 citations

Natural segregation of nucleolar components of liver cells in newts

1972 • 13 citations

Comparison of the effects of coxsackievirus A9 and of actinomycin D on the nucleolar ultrastructure of monkey kidney cells

1972 • 12 citations

Effects of actinomycin D on the oligonucleotide composition of nucleolar 45-S RNA of Novikoff hepatoma ascites cells

1969 • 12 citations

Effects of antitumor agents on the synthesis of nucleolar DNA.

1967 • 12 citations

Nature of the so-called fibrillar component in the segregated nucleolus after treatment of actinomycin D.

1972 • 12 citations

The relationship between protein synthesis and ribosomal DNA amplification in Xenopus laevis

1971 • 11 citations

A dense particulate component of nucleoli of rat intestinal crypt cells

1969 • 11 citations

Intranucleolar dense particles in rat hepatic cell nucleoli

1970 • 11 citations

Quantitation of the ultrastructural components of nucleoli of rat trigeminal ganglia

1970 • 11 citations

Some properties of ribonucleoprotein particles in the isolated nucleoli of mouse ascites tumor cells

1969 • 10 citations

DNA SYNTHETIC PATTERN IN THE NUCLEOLUS

1970 • 10 citations

ULTRASTRUCTURAL EVIDENCE FOR THE STIMULATION OF NUCLEAR RIBONUCLEIC ACID SYNTHESIS BY OESTRADIOL-17β IN THE VAGINAL EPITHELIUM OF THE OVARIECTOMIZED MOUSE

1970 • 9 citations

Isolation and ultrastructure of nucleoli altered in vivo

1968 • 8 citations

The ultrastructure of Bowen's disease: nuclear and nucleolar lesions.

1970 • 8 citations

DNA Replication Patterns of Normal Human Leukocyte Cultures

1966 • 7 citations

Report of the nucleolus nomenclature committee.

1966 • 6 citations

Natural segregation of the ribonucleoprotein components of the nucleoli of chloragogen cells in Tubifex

1969 • 6 citations

DNA SYNTHETIC PATTERN IN THE NUCLEOLUS

1970 • 5 citations

Ribosomal precursor particles from plant nucleoli

1972 • 5 citations

The origin of fibrillar particles sometimes seen in plant nucleoli

1969 • 5 citations

Effect of ACTH on the nucleolar size of adrenal cortical cells and of liver cells

1971 • 4 citations

Nucleolus and Nuclear Body in Prophase Spermatocytes ofHelix Aspersa

1971 • 4 citations

Electron microscopic study of nuclear and nucleolar changes in cells infected with canine distemper virus (CDV)

1972 • 4 citations

The effect of actinomycin d in vivo upon peripheral nucleoli and other nuclear organelles in oocytes of Triturus cristatus

1972 • 3 citations

Chromosomal control of nucleolar synthesis

1964 • 2 citations

Stimulation of 14C-Leucine Incorporation into Protein in vitro by Rapidly Sedimenting Nucleolar RNA from AH-130 Hepatoma Cells

1969 • 2 citations