The Value of Adjuvant Therapy after Radical Surgery for Colorectal Cancer

RECURRENCE AND SURVIVAL AFTER TOTAL MESORECTAL EXCISION FOR RECTAL CANCER

1986 • 2,585 citations

Levamisole and Fluorouracil for Adjuvant Therapy of Resected Colon Carcinoma

1990 • 2,226 citations

The linear-quadratic formula and progress in fractionated radiotherapy

1989 • 2,150 citations

Effective Surgical Adjuvant Therapy for High-Risk Rectal Carcinoma

1991 • 1,888 citations

Prolongation of the Disease-Free Interval in Surgically Treated Rectal Carcinoma

1985 • 1,097 citations

Adjuvant Therapy for Patients With Colon and Rectal Cancer

1990 • 1,047 citations

Postoperative Adjuvant Chemotherapy or Radiation Therapy for Rectal Cancer: Results From NSABP Protocol R-011

1988 • 1,025 citations

Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.

1989 • 911 citations

Areas of failure found at reoperation (second or symptomatic look) following “curative surgery” for adenocarcinoma of the rectum:Clinicopathologic correlation and implications for adjuvant therapy

1974 • 755 citations

Surgical adjuvant therapy of large-bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil. The North Central Cancer Treatment Group and the Mayo Clinic.

1989 • 694 citations

Preoperative Radiotherapy as Adjuvant Treatment in Rectal Cancer

1988 • 667 citations

Pre- or Postoperative Radiotherapy in Rectal and Rectosigmoid Carcinoma Report from a Randomized Multicenter Trial

1990 • 582 citations

Preoperative or postoperative irradiation in adenocarcinoma of the rectum

1993 • 547 citations

A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma.

1988 • 513 citations

Local recurrence following ‘curative’ surgery for large bowel cancer: I. The overall picture

1984 • 492 citations

Adjuvant Therapy of Colorectal Cancer

1988 • 376 citations

Preoperative short-term radiation therapy in operable rectal carcinoma: A prospective randomized trial

1990 • 372 citations

A randomized controlled trial of adjuvant portal vein cytotoxic perfusion in colorectal cancer

1985 • 302 citations

Preoperative irradiation for carcinoma of the rectum and rectosigmoid colon: Report of a national veterans administration randomized study

1975 • 274 citations

Cumulative radiation effect part I: Fractionated treatment regimes

1971 • 273 citations

Postoperative radiotherapy in Dukes' B and C carcinoma of the rectum and rectosigmoid: A randomized multicenter study

1986 • 263 citations

Applications of dose intensity to problems in chemotherapy of breast and colorectal cancer.

1987 • 236 citations

Preoperative irradiation in operable cancer of the rectum: report of the Toronto trial.

1977 • 236 citations

Preoperative radiation and surgery for cancer of the rectum: Veterans administration surgical oncology group trial II

1986 • 227 citations

The evaluation of low dose pre-operative X-ray therapy in the management of operable rectal cancer; results of a randomly controlled trial

1984 • 219 citations

Adjuvant therapy of Dukes' A, B, and C adenocarcinoma of the colon with portal-vein fluorouracil hepatic infusion: preliminary results of National Surgical Adjuvant Breast and Bowel Project Protocol C-02.

1990 • 212 citations

Pre-Operative assessment of local invasion in rectal cancer: Digital examination, endoluminal sonography or computed tomography?

1986 • 171 citations

Adjuvant postoperative radiotherapy in carcinoma of the rectum and rectosigmoid

1985 • 141 citations

Local recurrences after surgical treatment for rectal carcinoma.

1984 • 127 citations

Subclinical disease

1984 • 116 citations

Pre- versus postoperative radiotherapy in rectal carcinoma: an interim report from a randomized multicentre trial

1985 • 111 citations

Superiority of sequential methotrexate, fluorouracil, and leucovorin to fluorouracil alone in advanced symptomatic colorectal carcinoma: a randomized trial.

1989 • 111 citations

Adjuvant Therapy for Resectable Colorectal Carcinoma With Fluorouracil Administered by Portal Vein Infusion

1990 • 108 citations

Preoperative radiotherapy in operable rectal cancer

1990 • 91 citations

Preoperative Radiation Therapy for Clinically Resectable Adenocarcinoma of the Rectum

1985 • 80 citations

The Overall Picture

1988 • 79 citations

Experimental studies on interactions of radiation and cancer chemotherapeutic drugs in normal tissues and a solid tumour

1986 • 78 citations

Tumor heterogeneity, tumor size, and radioresistance

1989 • 68 citations

Preoperative Irradiation with High-Dose Fractionation in Adenocarcinoma of the Rectum and Rectosigmoid

1982 • 67 citations

Anterior resection and primary anastomosis following high dose preoperative irradiation for adenocarcinoma of the recto-sigmoid

1978 • 64 citations

Predicting local recurrence of carcinoma of the rectum after preoperative radiotherapy and surgery

1989 • 51 citations

High dose preoperative radiation and sphincter preservation in the treatment of rectal cancer

1987 • 30 citations

Pre-operative radiotherapy in operable rectal cancer: Interim report of a trial carried out by the Rectal Cancer Group

1985 • 22 citations

Adjuvant intraportal chemotherapy for colorectal cancer ; 4year results of the randomized Swiss study.

1989 • 12 citations

Pre-operative radiotherapy in operable rectal cancer: interim report of a trial carried out by the Rectal Cancer Group

1986 • 12 citations

Design of combination biotherapy studies: future goals and challenges.

1990 • 10 citations

Serum, urine and peritoneal fluid levels of 5-FU following intraperitoneal administration.

1987 • 8 citations

Levamisole and the New Era of Chemoimmunotherapy

1991 • 8 citations

Technique of postoperative pelvic radiation in the management of rectal and rectosigmoid carcinoma.

1987 • 5 citations

Intraperitoneal chemotherapy: Belly-bath or pain-in-the-side?

1987 • 2 citations