Antioxidant Mechanism and Protection of Nigral Neurons Against MPP+ Toxicity by Deprenyl (Selegiline)

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones.

1978 • 1,073 citations

Effect of Deprenyl on the Progression of Disability in Early Parkinson's Disease

1989 • 913 citations

The Effect of Deprenyl (Selegiline) on the Natural History of Parkinson's Disease

1989 • 621 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1992 • 457 citations

Increased life expectancy resulting from addition of l-deprenyl to Madopar� treatment in Parkinson's disease: A longterm study

1985 • 437 citations

Irreversible Inhibition of Mitochondrial Complex I by 1‐Methyl‐4‐Phenylpyridinium: Evidence for Free Radical Involvement

1992 • 371 citations

1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles

1990 • 323 citations

IMPLICATIONS OF COMBINED TREATMENT WITH 'MADOPAR' AND L-DEPRENIL IN PARKINSON'S DISEASE

1977 • 293 citations

(−) deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats

1991 • 258 citations

Intracranial microdialysis of salicylic acid to detect hydroxyl radical generation through dopamine autooxidation in the caudate nucleus: Effects of MPP+

1992 • 234 citations

Deprenyl suppresses the oxidant stress associated with increased dopamine turnover

1989 • 210 citations

In Vivo Lipid Peroxidation in Rat Brain Following Intracortical Fe²⁺ Injection

1984 • 182 citations

Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism.

1993 • 177 citations

Apparent antioxidant effect of l-deprenyl on hydroxyl radical formation and nigral injury elicited by MPP+ in vivo

1993 • 144 citations

Maintenance on l-deprenyl prolongs life in aged male rats

1990 • 138 citations

Protection against DSP-4-induced neurotoxicity by deprenyl is not related to its inhibition of MAO B

1990 • 129 citations

Deprenyl in the Treatment of Symptom Fluctuations in Advanced Parkinsonʼs Disease

1988 • 127 citations

CURRENT CONCEPTS CONCERNING RADIOPROTECTIVE AND CRYOPROTECTIVE PROPERTIES OF DIMETHYL SULFOXIDE IN CELLULAR SYSTEMS*

1975 • 123 citations

Novel inhibitors of iron-dependent lipid peroxidation for neurodegenerative disorders

1992 • 117 citations

Ferrous‐Citrate Complex and Nigral Degeneration: Evidence for Free‐radical Formation and Lipid Peroxidation^a

1994 • 115 citations

The pharmacology of selegiline ((−)deprenyl). New aspects

1989 • 110 citations

Deprenyl Protects Dopamine Neurons from the Neurotoxic Effect of 1‐Methyl‐4‐Phenylpyridinium Ion

1985 • 109 citations

In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+

1992 • 106 citations

R-(-)-deprenyl (Selegiline, Movergan) facilitates the activity of the nigrostriatal dopaminergic neuron.

1987 • 103 citations

TYRAMINE ANTAGONISTIC PROPERTIES OF AGN 1135, AN IRREVERSIBLE INHIBITOR OF MONOAMINE OXIDASE TYPE B

1981 • 103 citations

The molecular pharmacology of L-deprenyl

1992 • 95 citations

Role of iron and iron chelation in dopaminergic-induced neurodegeneration: Implication for Parkinson's disease

1992 • 92 citations

Neurotoxic damage to the nigrostriatal system in rats following intranigral administration of MPDP+ and MPP+

1988 • 82 citations

Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a “redox cycling” mechanism in MPTP neurotoxicity

1987 • 74 citations

Enhanced hydroxyl radical generation by 2′‐methyl analog of MPTP: Suppression by clorgyline and deprenyl

1992 • 64 citations

Effects of MPTP, MPP+ and paraquat on mitochondrial potential and oxidative stress

1989 • 58 citations

Intra- and extra-dopamine-synaptosomal localization of monoamine oxidase in striatal homogenates from four species

1987 • 55 citations

Suppression of hydroxyl radical formation by MAO inhibitors: a novel possible neuroprotective mechanism in dopaminergic neurotoxicity

1994 • 48 citations

(-)Deprenyl-Medication: A Strategy To Modulate the Age-Related Decline of the Striatal Dopaminergic System

1992 • 46 citations

(?)-Deprenyl can induce soluble superoxide dismutase in rat striata

1991 • 38 citations

Hydroxyl Free Radical (·OH) Formation Reflected by Salicylate Hydroxylation and Neuromelanin

1993 • 35 citations

Changes in lipid peroxidation induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in mouse brain homogenates

1987 • 35 citations

Induction by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of lipid peroxidation invivo in vitamin E deficient mice

1990 • 32 citations

Clinical Advances in Monoamine Oxidase Inhibitor Therapies

1996 • 30 citations

Protective effect of deprenyl against 1-methyl-4-phenylpyridinium neurotoxicity in rat striatum

1993 • 28 citations

Dopamine in the Extrapyramidal Motor Function A Study Based upon the MPTP‐Induced Primate Model of Parkinsonism”a

1988 • 25 citations

(−)Deprenyl and (−)parafluorodeprenyl-treatment prevents age-related pigment changes in the substantia nigra. A TV-image analysis of neuromelanin

1992 • 23 citations

MPP⁺ Enhances Potassium‐Evoked Striatal Dopamine Release through a ω‐ConOtoxin‐Insensitive, Tetrodotoxin‐ and Nimodipine‐ Sensitive Calcium‐Dependent Mechanism

1991 • 22 citations

Neurotoxins and Monoamine Oxidase B Inhibitors: Possible Mechanisms for the Neuroprotective Effect of (—)-Deprenyl

1993 • 13 citations

An electrochemical study of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its oxidation products

1988 • 10 citations

Effect of 1-deprenyl on lipid peroxidation in rat brain homogenate

1990 • 4 citations

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