Animal Models of Parkinsonism

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,922 citations

Dopamine (3-hydroxytyramine) and brain function.

1966 • 1,401 citations

Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,271 citations

3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists

1957 • 1,233 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1984 • 1,007 citations

Effect of Deprenyl on the Progression of Disability in Early Parkinson's Disease

1989 • 913 citations

Striatal Dopamine Release after Amphetamine or Nerve Degeneration Revealed by Rotational Behaviour

1971 • 912 citations

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

1984 • 772 citations

Animal models in psychiatry and neurology

1978 • 648 citations

The Effect of Deprenyl (Selegiline) on the Natural History of Parkinson's Disease

1989 • 621 citations

Functional Role of the Nigro‐Neostriatal Dopamine Neurons*)

1966 • 394 citations

Mechanisms of action of 6-hydroxydopamine

1975 • 353 citations

Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys

1984 • 323 citations

Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP

1984 • 313 citations

Positron emission tomography after MPTP: observations relating to the cause of Parkinson's disease

1985 • 310 citations

Hemiparkinsonism in monkeys after unilateral internal carotid artery artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1986 • 309 citations

Specificity of 6-hydroxydopamine induced degeneration of central monoamine neurones: An electron and fluorescence microscopic study with special reference to intracerebral injection on the nigro-striatal dopamine system

1973 • 295 citations

Parkinsonism Induced By 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine (MPTP): Implications for Treatment and the Pathogenesis of Parkinson’s Disease

1984 • 277 citations

Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes

1985 • 270 citations

Striatal dopamine deficiency in parkinson's disease: Role of aging

1989 • 266 citations

IV. MPTP, MPP+ and mitochondrial function

1987 • 249 citations

The Clinical Syndrome of Striatal Dopamine Deficiency

1985 • 241 citations

A 6-hydroxydopamine-induced selective parkinsonian rat model

1989 • 241 citations

The striatal dopamine dependency of life span in male rats. Longevity study with (−)deprenyl

1988 • 208 citations

Movement Disorders of Aged Rats: Reversal by Dopamine Receptor Stimulation

1979 • 207 citations

STRIATAL AMINES, EXPERIMENTAL TREMOR AND THE EFFECT OF HARMALINE IN THE MONKEY

1966 • 205 citations

Astrocytes convert the parkinsonism inducing neurotoxin, MPTP, to its active metabolite, MPP+

1987 • 200 citations

Neurochemical and behavioral effects of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) in rat, guinea pig, and monkey.

1984 • 167 citations

Injection of 6-hydroxydopamine into the substantia nigra of the rat. II. Diffusion and specificity

1973 • 159 citations

Non-specific histopathological changes induced by the intracerebral injection of 6-hydroxy-dopamine (6-OH-DA)

1972 • 149 citations

MPTP: A neurotoxin producing a parkinsonian syndrome

1987 • 133 citations

Variability and functional recovery in the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism in monkeys

1986 • 128 citations

Evidence that punctate intracerebral administration of 6-hydroxydopamine fails to produce selective neuronal degeneration

1974 • 111 citations

Striatal dopamine, sexual activity and lifespan. Longevity of rats treated with (-) deprenyl

1989 • 107 citations

The relationship between loss of dopamine nerve terminals, striatal [3H]spiroperidol binding and rotational behavior in unilaterally 6-hydroxydopamine-lesioned rats

1981 • 106 citations

R-(-)-deprenyl (Selegiline, Movergan) facilitates the activity of the nigrostriatal dopaminergic neuron.

1987 • 103 citations

Transplantation into the human brain: present status and future possibilities.

1989 • 92 citations

Cataleptic state and hypothermia in mice, caused by central cholinergic stimulation and antagonized by anticholinergic and antidepressant drugs

1968 • 87 citations

MPTP-Induced Parkinsonism in the Monkey: Neurochemical Pathology, Complications of Treatment and Pathophysiological Mechanisms

1987 • 85 citations

Parkinsonian akinesia, rigidity and tremor in the monkey

1976 • 70 citations

MPTP-induced parkinsonism as a model for Parkinson's disease

1989 • 69 citations

A method for simultaneous recording of eight behavioral parameters related to monoamine neurotransmission

1978 • 67 citations

L-Dopa esters as potential prodrugs: behavioural activity in experimental models of Parkinson's disease

1987 • 54 citations

Extrapyramidal side-effects

1979 • 48 citations

Favorable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson's disease.

1988 • 47 citations

Asymptomatic striatal dopamine depletion: PET scans in unilateral MPTP monkeys

1988 • 42 citations

Drug-induced dyskinesia in primates rendered hemiparkinsonian by intracarotid administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1989 • 42 citations

The Use of the MPTP-Treated Mouse as an Animal Model of Parkinsonism

1987 • 42 citations

Further treatment with MPTP does not produce parkinsonism in marmosets showing behavioural recovery from motor deficits induced by an earlier exposure to the toxin

1989 • 40 citations

Animal models of parkinsonism

1981 • 39 citations

III. Bioactivation of MPTP: Reactive metabolites and possible biochemical sequelae

1987 • 39 citations

Tremors and tremorogenic agents

1972 • 33 citations

RELATIONSHIP BETWEEN ANTI‐ACETYLCHOLINE AND ANTI‐TREMORINE ACTIVITY IN ANTI‐PARKINSONIAN AND RELATED DRUGS

1962 • 30 citations

Tremors and tremorogenic agents

1973 • 30 citations

Animal and Clinical Pharmacologic Techniques in Drug Evaluation.

1965 • 29 citations

Computerized rotometer apparatus for recording circling behavior.

1989 • 25 citations

Protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism by the catecholamine uptake inhibitor nomifensine: Behavioral analysis in monkeys with partial striatal dopamine depletions

1989 • 15 citations

Antiparkinsonian drugs and dopaminergic neostriatal mechanisms: Studies in rats with unilateral 6-hydroxydopamine (=6-OH-DA)-induced degeneration of the nigro-neostriatal da pathway and quantitative recording of rotational behaviour

1976 • 15 citations

Experimental Therapeutics Directed at the Pathogenesis of Parkinson’s Disease

1989 • 14 citations

The modern management of Parkinson's disease.

1990 • 13 citations

Device for quantitating tremor activity in mice: Antitremor activity of atropine versus soman- and oxotremorine-induced tremors

1989 • 12 citations

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