Telomere length of in vivo expanded CD4+CD25+ regulatory T-cells is preserved in cancer patients

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Telomere measurement by quantitative PCR

2002 • 3,209 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Conservation of the human telomere sequence (TTAGGG)n among vertebrates.

1989 • 809 citations

Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation

2002 • 713 citations

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

2004 • 525 citations

Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells

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CD4⁺CD25⁺ regulatory T cells in patients with gastrointestinal malignancies

2003 • 474 citations

Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

1995 • 424 citations

Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells

2002 • 246 citations

Cutting Edge: Telomerase Activation in Human T Lymphocytes Does Not Require Increase in Telomerase Reverse Transcriptase (hTERT) Protein But Is Associated with hTERT Phosphorylation and Nuclear Translocation

2001 • 235 citations

CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis

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Telomerase regulation during entry into the cell cycle in normal human T cells.

1996 • 206 citations

Inhibition of cytolytic T lymphocyte proliferation by autologous CD4+/CD25+ regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-beta.

2002 • 186 citations

Transfer of the human telomerase reverse transcriptase(TERT) gene into T lymphocytes results in extension of replicative potential

2001 • 180 citations

Regulation of Telomere Length and Telomerase in T and B Cells

1998 • 154 citations

Telomerase levels control the lifespan of human T lymphocytes

2003 • 138 citations

The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection

2001 • 113 citations

Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress–induced apoptosis

2003 • 109 citations

Human CD4+CD25+ Regulatory T Cells Share Equally Complex and Comparable Repertoires with CD4+CD25− Counterparts

2004 • 95 citations

Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT

2005 • 58 citations

Early Block in Maturation Is Associated with Thymic Involution in Mammary Tumor-Bearing Mice

2000 • 48 citations

Telomerase Activation and Rejuvenation of Telomere Length in Stimulated T Cells Derived from Serially Transplanted Hematopoietic Stem Cells

2002 • 37 citations

Mechanisms regulating telomerase activity in murine T cells.

1997 • 32 citations

A Phase II Study of Dasatinib in Patients with Chronic Myeloid Leukemia (CML) in Lymphoid Blast Crisis or Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Who Are Resistant or Intolerant to Imatinib: The ‘START-L’ CA180015 Study.

2005 • 27 citations

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