ANGIOTENSIN-CONVERTING ENZYME INHIBITORS: PAST, PRESENT, AND BRIGHT FUTURE

Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive Agents

1977 • 1,851 citations

A new class of angiotensin-converting enzyme inhibitors

1980 • 704 citations

Captopril-Induced Functional Renal Insufficiency in Patients with Bilateral Renal-Artery Stenoses or Renal-Artery Stenosis in a Solitary Kidney

1983 • 658 citations

A placebo-controlled trial of captopril in refractory chronic congestive heart failure

1983 • 562 citations

CAPTOPRIL IN THE TREATMENT OF CLINICAL HYPERTENSION AND CARDIAC FAILURE

1979 • 393 citations

Sustained Effectiveness of Converting-Enzyme Inhibition in Patients with Severe Congestive Heart Failure

1980 • 380 citations

Limitation of experimental infarct size by an angiotensin-converting enzyme inhibitor.

1982 • 321 citations

Captopril

1980 • 315 citations

Antihypertensive therapy with MK 421: angiotensin II--renin relationships to evaluate efficacy of converting enzyme blockade.

1982 • 243 citations

Potent new inhibitors of human renin

1982 • 239 citations

ANTIHYPERTENSIVE EFFECT OF THE NEW ORAL ANGIOTENSIN CONVERTING ENZYME INHIBITOR "MK-421".

1981 • 189 citations

Antihypertensive Therapy with MK 4211

1982 • 188 citations

IMPROVEMENT OF CHRONIC CONGESTIVE HEART-FAILURE BY ORAL CAPTOPRIL

1979 • 180 citations

Role of kinins in the acute antihypertensive effect of the converting enzyme inhibitor, captopril.

1981 • 159 citations

Actions of angiotensin on adrenergic nerve endings.

1978 • 149 citations

Angiotensin-converting enzyme inhibition and prostaglandins

1982 • 149 citations

Splint renal function after captopril in unilateral renal artery stenosis.

1984 • 146 citations

Discrepancy between antihypertensive effect and angiotensin converting enzyme inhibition by captopril.

1980 • 145 citations

Factors related to first dose hypotensive effect of captopril: prediction and treatment.

1983 • 138 citations

Interaction of angiotensin-converting enzyme inhibitors with the function of the sympathetic nervous system

1982 • 133 citations

Relationships between the kallikrein-kinin and prostaglandin systems

1979 • 111 citations

Actions of angiotensin on adrenergic nerve endings.

1978 • 104 citations

LOW-DOSE CAPTOPRIL IN CHRONIC HEART FAILURE: ACUTE HAEMODYNAMIC EFFECTS AND LONG-TERM TREATMENT

1980 • 104 citations

Captopril in primary pulmonary hypertension.

1983 • 101 citations

COMBINED TREATMENT OF SEVERE INTRACTABLE HYPERTENSION WITH CAPTOPRIL AND DIURETIC

1980 • 96 citations

Comparison of captopril and hydrochlorothiazide alone and in combination in mild to moderate essential hypertension.

1982 • 96 citations

Racial differences in response to low-dose captopril are abolished by the addition of hydrochlorothiazide.

1982 • 93 citations

Effects of an angiotensin-converting enzyme inhibitor (captopril) on blood pressure in anephric subjects.

1980 • 92 citations

Increase in plasma aldosterone during prolonged captopril treatment

1982 • 83 citations

Effect of angiotensin-converting enzyme inhibition on circulating and local kinin levels

1982 • 80 citations

Reactive Hyperreninemia in Renovascular Hypertension After Angiotensin Blockade with Saralasin or Converting Enzyme Inhibitor

1979 • 76 citations

Clinical use of an orally acting converting enzyme inhibitor: captopril.

1980 • 74 citations

HAEMODYNAMIC, HORMONAL, AND ELECTROLYTE RESPONSES TO CAPTOPRIL IN RESISTANT HEART FAILURE

1981 • 74 citations

Increased Adrenal Sensitivity to Angiotensin II in Idiopathic Hyperaldosteronism*

1978 • 74 citations

Acute and chronic treatment of severe and malignant hypertension with the oral angiotensin-converting enzyme inhibitor captopril.

1981 • 68 citations

Captopril: Evaluation of Low Doses, Twice-Daily Doses and the Addition of Diuretic for the Treatment of Mild to Moderate Hypertension

1982 • 67 citations

Increased renal plasma flow in long-term enalapril treatment of hypertension

1983 • 57 citations

Captopril as treatment for patients with pulmonary hypertension. Problem of variability in assessing chronic drug treatment.

1982 • 55 citations

Racial differences in response to low‐dose captopril are abolished by the addition of hydrochlorothiazide.

1982 • 55 citations

Effect of Angiotensin II and Converting Enzyme Inhibitor (Captopril) on Blood Pressure, Plasma Renin Activity and Aldosterone in Primary Aldosteronism

1981 • 53 citations

Effects of captopril in acute and chronic heart failure. Correlations with plasma levels of noradrenaline, renin, and aldosterone.

1983 • 51 citations

Long-term antihypertensive therapy with captopril.

1983 • 49 citations

Captopril in the management of hypertension with renal artery stenosis: Its long-term effect as a predictor of surgical outcome

1982 • 48 citations

Enalapril in the treatment of hypertension with renal artery stenosis.

1983 • 48 citations

Hemodynamic and hormonal responses during captopril therapy for heart failure: Acute, chronic and withdrawal studies

1982 • 47 citations

Captopril‐Induced Skin Eruptions

1982 • 47 citations

A Comparative Pilot Study of Enalapril, A New Converting Enzyme Inhibitor, and Hydrochlorothiazide in Essential Hypertension

1982 • 45 citations

Clinical experience with captopril in the treatment of severe drug-resistant hypertension

1982 • 44 citations

Autonomic and baroreflex function after captopril in hypertension

1983 • 42 citations

Determinants of acute and long-term response to converting enzyme inhibitors in congestive heart failure

1982 • 41 citations

Relationship of antihypertensive effect of enalapril to serum MK-422 levels and angiotensin converting enzyme inhibition.

1983 • 37 citations

Role of sympathetic nervous system activity in the blood pressure response to long-term captopril therapy in severely hypertensive patients

1982 • 32 citations

Differences in response to the peptidyldipeptide hydrolase inhibitors SQ 20,881 and SQ 14,225 in normal-renin essential hypertension.

1980 • 31 citations

Long-term converting-enzyme inhibition as a guide to surgical curability of hypertension associated with renovascular disease

1983 • 30 citations

Low-Dose Captopril

1982 • 30 citations

Relief from digital vasospasm by treatment with captopril and its complete inhibition by serine proteinase inhibitors in Raynaud's phenomenon.

1982 • 26 citations

The renin--angiotensin system in refractory heart failure: clinical, hemodynamic and hormonal effects of captopril and enalapril

1983 • 24 citations

The Therapeutic use of a new Potassium-Sparing Diuretic, Amiloride, and a Converting Enzyme Inhibitor, Mk-421, in Preventing Hypokalemia Associated with Primary and Secondary Hyperaldosteronism

1983 • 23 citations

Reversal of Scleroderma Renal Crisis for More Than Two Years in a Patient Treated with Captopril

1983 • 20 citations

Repeated renal failure with use of captopril in a cystinotic renal allograft recipient.

1982 • 20 citations

Vasodilator therapy of severe congestive heart failure: The special importance of angiotensin-converting enzyme inhibition with captopril

1982 • 19 citations

Treatment of hypertension with angiotensin converting enzyme inhibitors.

1982 • 19 citations

Long-term treatment of bartter's syndrome with captopril.

1982 • 15 citations

The use of captopril in the management of cardiac failure.

1984 • 15 citations

Long-term captopril therapy in congestive heart failure: Serial hemodynamic and echocardiographic changes

1982 • 13 citations

CAPTOPRIL AND RESISTANT ASCITES

1983 • 10 citations

Captopril in congestive heart failure.

1982 • 10 citations

DOES CAPTOPRIL CAUSE RENAL DAMAGE IN HYPERTENSIVE PATIENTS?

1982 • 9 citations

Effects of SQ 20881 and captopril on mesenteric, renal, and iliac vasculatures

1983 • 9 citations

Controlled trial of captopril for heart failure: Effects on hemodynamics, scintigraphy and exercise tolerance

1982 • 6 citations

Effects of Captopril in Bartter's Syndrome

1981 • 4 citations

Captopril in Idiopathic Edema

1983 • 3 citations