A CD30 responsive element in the germline ϵ promoter that is distinct from and inhibitory to the CD40 response element

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures.

1987 • 1,703 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production.

1990 • 353 citations

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

1993 • 340 citations

Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen.

1991 • 334 citations

Recombination between immunoglobulin variable region gene segments is enhanced by transcription

1986 • 308 citations

Mitogen- and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching

1988 • 277 citations

Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways.

1991 • 270 citations

Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4

1993 • 256 citations

An HMG-like protein that can switch a transcriptional activator to a repressor

1994 • 220 citations

CD40 stimulation provides an IFN-gamma-independent and IL-4-dependent differentiation signal directly to human B cells for IgE production.

1991 • 219 citations

A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.

1993 • 206 citations

Induction of the transcription factors NF-кB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor

1995 • 192 citations

Immunoregulatory role of CD40 in human B cell differentiation.

1993 • 122 citations

Allergy‐associated Iϵ and Fcϵ receptor II (CD23b) genes activated via binding of an interleukin‐4‐induced transcription factor to a novel responsive element

1993 • 121 citations

Sequences of human immunoglobulin switch regions: implications for recombination and transcription

1990 • 105 citations

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes.

1985 • 99 citations

Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer.

1992 • 98 citations

Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease

1994 • 96 citations

Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells.

1994 • 86 citations

Regulation of murine B cell growth and differentiation by CD30 ligand

1995 • 83 citations

Cross-linking of CD30 induces HIV expression in chronically infected T cells

1995 • 80 citations

Production of sterile transcripts of C_γ genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells

1989 • 74 citations

Regulation of human B cell function by recombinant CD40 ligand and other TNF-related ligands.

1995 • 61 citations

Human interleukin‐13 activates the interleukin‐4‐dependent transcription factor NF‐IL4 sharing a DNA binding motif with an interferon‐γ‐induced nuclear binding factor

1994 • 57 citations

Activation of HIV expression by CD30 triggering in CD4+ T cells from HIV-infected individuals

1995 • 54 citations

Regulation of the expression of human C epsilon germline transcript. Identification of a novel IL-4 responsive element.

1993 • 49 citations

A bifunctional control element in the human IgE germline promoter involved in repression and IL-4 activation

1994 • 44 citations

An antisense oligonucleotide complementary to a sequence in I gamma 2b increases gamma 2b germline transcripts, stimulates B cell DNA synthesis, and inhibits immunoglobulin secretion.

1992 • 43 citations

Effect of downregulation of germline transcripts on immunoglobulin A isotype differentiation.

1993 • 39 citations

The human l_α1 and l_α2 germline promoter elements: proximal positive and distal negative elements may regulate the tissue specific expression of C_α1 and C_α2 germline transcripts

1993 • 39 citations

Evidence for a CD40 response element, distinct from the IL-4 response element, in the germline ε promoter

1995 • 22 citations

Characterization of the enhancer region for germline transcription of the gamma 3 constant region gene of human immunoglobulin

1991 • 17 citations