Evaluation of Selected Chemotypes in Coupled Cellular and Molecular Target-Based Screens Identifies Novel HIV-1 Zinc Finger Inhibitors

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy

1995 • 1,997 citations

Prevention of SIV Infection in Macaques by ( R )-9-(2-Phosphonylmethoxypropyl)adenine

1995 • 560 citations

Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus

1990 • 531 citations

A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain

1987 • 525 citations

Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA

1990 • 380 citations

Point mutants of Moloney murine leukemia virus that fail to package viral RNA: evidence for specific RNA recognition by a "zinc finger-like" protein sequence.

1988 • 312 citations

Amino acid sequence homology in gag region of reverse transcribing elements and the coat protein gene of cauliflower mosaic virus

1986 • 305 citations

Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution‐state structure of the nucleocapsid protein from HIV‐1

1992 • 291 citations

Primary structure of the low molecular weight nucleic acid-binding proteins of murine leukemia viruses.

1981 • 153 citations

Structure of a molecular chaperone from a thermophilic archaebacterium

1993 • 134 citations

Point mutations in the proximal Cys-His box of Rous sarcoma virus nucleocapsid protein

1990 • 123 citations

A preference-based free-energy parameterization of enzyme-inhibitor binding. Applications to HIV-1-protease inhibitor design

1995 • 117 citations

Zinc‐ and sequence‐dependent binding to nucleic acids by the N‐terminal zinc finger of the HIV‐1 nucleocapsid protein: NMR structure of the complex with the Psi‐site analog, dACGCC

1993 • 113 citations

The nucleocapsid protein isolated from HIV-1 particles binds zinc and forms retroviral-type zinc fingers

1990 • 111 citations

Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particles

1996 • 74 citations

Human immunodeficiency virus type-1 (HIV-1) replication is unaffected by human secretory leukocyte protease inhibitor

1996 • 40 citations