Defects in the apoptotic machinery of cancer cells: role in drug resistance

The Hallmarks of Cancer

2000 • 27,569 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Apoptosis

2002 • 2,190 citations

Death and anti-death: tumour resistance to apoptosis

2002 • 1,963 citations

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1999 • 1,540 citations

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

2002 • 1,325 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

2001 • 1,106 citations

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1996 • 1,001 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

An alternative, nonapoptotic form of programmed cell death

2000 • 930 citations

Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

1998 • 894 citations

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

2000 • 799 citations

Heat Shock Proteins: Endogenous Modulators of Apoptotic Cell Death

2001 • 781 citations

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

2002 • 739 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

1999 • 663 citations

Programmed cell death: alive and well in the new millennium

2001 • 663 citations

Escaping Cell Death: Survival Proteins in Cancer

1999 • 629 citations

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

2000 • 617 citations

Apaf-1 is a transcriptional target for E2F and p53

2001 • 590 citations

Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria

2002 • 491 citations

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

2002 • 453 citations

Characterization of XIAP-Deficient Mice

2001 • 425 citations

Caspase-2 Acts Upstream of Mitochondria to Promote Cytochromec Release during Etoposide-induced Apoptosis

2002 • 421 citations

Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

2001 • 409 citations

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 • 372 citations

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs.

2001 • 329 citations

A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma

1997 • 319 citations

Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis.

2001 • 297 citations

The role of the Bcl-2 protein family in cancer

2003 • 245 citations

Apoptosis in the absence of caspase 3

2001 • 231 citations

Cytotoxic drugs and the CD95 pathway

1999 • 212 citations

Drug resistance in melanoma: mechanisms, apoptosis, and new potential therapeutic targets.

2001 • 206 citations

Triggering of apoptosis by cathepsins

2001 • 204 citations

Apaf-1/Cytochrome c-independent and Smac-dependent Induction of Apoptosis in Multiple Myeloma (MM) Cells

2001 • 202 citations

Loss of caspase-1 and caspase-3 protein expression in human prostate cancer.

2001 • 200 citations

The kiss of death: promises and failures of death receptors and ligands in cancer therapy

2001 • 200 citations

A Caspase-9 Variant Missing the Catalytic Site Is an Endogenous Inhibitor of Apoptosis

1999 • 179 citations

Oncogene-dependent apoptosis is mediated by caspase-9

1998 • 174 citations

Generation and Characterization of Smac/DIABLO-Deficient Mice

2002 • 171 citations

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative–(BMS 247550) and Apo-2L/TRAIL–induced apoptosis

2002 • 162 citations

SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)

2002 • 161 citations

CARD games in apoptosis and immunity

2002 • 159 citations

Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis.

1999 • 157 citations

Identification of Inhibitors of TRAIL-induced Death (ITIDs) in the TRAIL-sensitive Colon Carcinoma Cell Line SW480 Using a Genetic Approach

2001 • 157 citations

Intracellular regulation of tumor necrosis factor–related apoptosis-inducing ligand–induced apoptosis in human multiple myeloma cells

2002 • 155 citations

Triggering caspase-independent cell death to combat cancer

2002 • 154 citations

Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas

2002 • 145 citations

Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance.

2002 • 145 citations

Apaf-1 protein deficiency confers resistance to cytochromec–dependent apoptosis in human leukemic cells

2001 • 143 citations

Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients.

2001 • 127 citations

Defective Cytochrome c-dependent Caspase Activation in Ovarian Cancer Cell Lines due to Diminished or Absent Apoptotic Protease Activating Factor-1 Activity

2001 • 124 citations

Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel- or etoposide-treated HL-60 cells.

1998 • 106 citations

The Inhibitor of Apoptosis Protein-Binding Domain of Smac Is Not Essential for Its Proapoptotic Activity

2001 • 105 citations

Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients

2001 • 103 citations

Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment

2002 • 96 citations

Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma

2001 • 91 citations

Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact.

2000 • 83 citations

Differences in Expression of Pro-Caspases in Small Cell and Non-small Cell Lung Carcinoma

1999 • 82 citations

Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia.

1999 • 77 citations

Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D

2001 • 74 citations

Lack of Correlation between Caspase Activation and Caspase Activity Assays in Paclitaxel-treated MCF-7 Breast Cancer Cells

2002 • 72 citations

Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma

2001 • 71 citations

Defective caspase-3 relocalization in non-small cell lung carcinoma

2001 • 71 citations

Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release

2002 • 59 citations

Resistance to CD95-mediated apoptosis through constitutive c-FLIP expression in a non-Hodgkin's lymphoma B cell line

2000 • 55 citations

Defective Apoptotic Signal Transduction Pathway Downstream of Caspase-3 in Human B-Lymphoma Cells: A Novel Mechanism of Nuclear Apoptosis Resistance

1999 • 55 citations

Evaluation of Apaf-1 and procaspases-2, -3, -7, -8, and -9 as potential prognostic markers in acute leukemia

2000 • 54 citations

Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN

2002 • 46 citations

Expression of Inhibitor of Apoptosis Proteins in Small- and Non-Small-Cell Lung Carcinoma Cells

2002 • 46 citations

Paradox of Bcl‐2 (and p53): why may apoptosis‐regulating proteins be irrelevant to cell death?

2001 • 41 citations

A Novel Single Amino Acid Deletion Caspase-8 Mutant in Cancer Cells That Lost Proapoptotic Activity

2002 • 38 citations

Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors

2001 • 35 citations

Raf-induced effects on the differentiation and apoptosis of skeletal myoblasts are determined by the level of Raf signaling: abrogation of apoptosis by Raf is downstream of caspase 3 activation

2002 • 25 citations

Cathepsin Inhibition Induces Apoptotic Death in Human Leukemia and Lymphoma Cells

2000 • 24 citations

Synthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth

1999 • 21 citations

Co‐transduction of Apaf‐1 and Caspase‐9 Augments Etoposide‐induced Apoptosis in U‐373MG Glioma Cells

2001 • 18 citations