Relation of the Antiproliferative Action of Methylglyoxal‐bis(guanylhydrazone) to the Natural Polyamines

Polyamines in rapid growth and cancer

1978 • 1,354 citations

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

1978 • 998 citations

On the Role of S-Adenosyl-L-methionine in the Biosynthesis of Spermidine by Rat Prostate

1969 • 415 citations

Use of the Dansyl Reaction in Biochemical Analysis

1970 • 373 citations

Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases

1972 • 344 citations

Increased cellular levels of spermidine or spermine are required for optimal DNA synthesis in lymphocytes activated by concanavalin A.

1975 • 168 citations

Factors affecting the dye exclusion test for cell viability

1964 • 140 citations

Isolation of mutant mammalian cells altered in polyamine transport

1978 • 123 citations

Effect of methylglyoxal bis(guanylhydrazone) on polyamine metabolism in normal and regenerating rat liver and rat thymus

1973 • 119 citations

Suppression of the formation of polyamines and macromolecules by <scp>dl</scp>-α-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in phytohaemagglutinin-activated human lymphocytes

1979 • 88 citations

Separation of two proteins required for synthesis of spermidine from S-adenosyl-L-methionine and putrescine in rat prostate

1971 • 79 citations

Relationship between inhibition of polyamine biosynthesis and DNA replication in activated lymphocytes.

1979 • 73 citations

Determination of polyamines in urine

1973 • 71 citations

The generality of methylglyoxal bis(guanylhydrazone)-induced mitochondrial damage and the dependence of this effect on cell proliferation.

1979 • 65 citations

S-adenosylmethionine decarboxylase from baker's yeast

1975 • 58 citations

Sensitive Enzymic determination of methylglyoxal bis(guanylhydrazone) in cultured cells and in animal tissues

1980 • 53 citations

Inhibitors of polyamine biosynthesis. 4. Effects of .alpha.-methyl-(.+-.)-ornithine and methylglyoxal bis(guanylhydrazone) on growth and polyamine content of L1210 leukemic cells of mice

1977 • 52 citations

Inhibition of diamine oxidase by 1,1-[(methylethanediylidene)-dinitrilo]-bis-(3-aminoguanidine) and 1,1'-[(methylethanediylidene)-dinitrilo]-diguanidine

1978 • 48 citations

The antimitochondrial action of 2-choloro-4', 4"-bis(2-imidazolin-2-yl)terephthalanilide and methylglyoxal bis(guanylhydrazone).

1966 • 40 citations

Dissociation of the early antiproliferative action of methylglyoxal bis(guanylhydrazone) from polyamine depletion

1979 • 37 citations

Inhibition of polyamine accumulation and cell proliferation by derivatives of diaminopropane in Ehrlich ascites cells grown in culture

1979 • 33 citations

Cellular polyamine depletion reduces DNA synthesis in isolated lymphocyte nuclei

1978 • 30 citations

A selective effect of methylglyoxal-bis(guanylhydrazone) on the synthesis of mitochondrial DNA of cultured L1210 leukemia cells.

1979 • 24 citations

Effects of polyamines and methylglyoxal bis(guanylhydrazone) on hepatic nuclear structure and deoxyribonucleic acid template activity

1975 • 23 citations

Diminished excretion of polyamines from BHK-21/C13 cells exposed to methylglyoxal bis(guanylhydrazone)

1978 • 19 citations

Involvement of polyamines in the progestin-induced stimulation of endometrial glycogen synthesis during organ culture

1977 • 15 citations

Suppression of phytohemagglutinin-induction of thymidine uptake in guinea pig lymphocytes by methylglyoxal bis(guanylhydrazone) treatment

1977 • 11 citations

Polyamine replacement by magnesium ions in BHK-21/C13 cells

1979 • 11 citations

Effects of polyamines and methylglyoxal bis(guanylhydrazone) on Escherichia coli ribonucleic acid polymerase and the template activity of hepatic cell nuclei in vitro

1978 • 8 citations

Bis-Guanylhydrazones

1975 • 7 citations