Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid.

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

1990 • 865 citations

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists.

1993 • 837 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock.

1993 • 552 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.

1990 • 509 citations

Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice.

1990 • 343 citations

IL-8 in septic shock, endotoxemia, and after IL-1 administration.

1991 • 313 citations

Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha.

1992 • 300 citations

Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

1991 • 279 citations

Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice.

1988 • 247 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

Phosphatidate-dependent protein phosphorylation.

1991 • 149 citations

Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C.

1990 • 134 citations

Binding sites for endotoxins (lipopolysaccharides) on human monocytes.

1991 • 113 citations

A randomized controlled trial of pentoxifylline for the prevention of regimen-related toxicities in patients undergoing allogeneic marrow transplantation

1993 • 99 citations

Interleukin-1 rapidly stimulates lysophosphatidate acyltransferase and phosphatidate phosphohydrolase activities in human mesangial cells.

1991 • 85 citations

Pentoxifylline attenuates neutrophil activation in experimental endotoxemia in chimpanzees.

1993 • 64 citations

Dynamics of the Diradylglycerol Responses of Stimulated Phagocytes

1989 • 59 citations

Passive immunization of mice against D factor blocks lethality and cytokine release during endotoxemia.

1993 • 54 citations

Phosphatidic acid and arachidonic acid each interact synergistically with glucagon to stimulate Ca2+ influx in the perfused rat liver

1987 • 26 citations

Lipid A activation of glomerular mesangial cells: mimicry of the bioactive lipid, phosphatidic acid

1992 • 20 citations

Effect of platelet-activating factor antagonist and leukotriene antagonist on endotoxin shock in the rat: role of the leukocyte.

1992 • 20 citations

Platelet‐activating factor stimulates phosphatidic acid formation in cultured rat mesangial cells: Roles of phospholipase D, diglyceride kinase, and de novo phospholipid synthesis

1993 • 19 citations

Evidence that lipopolysaccharide and pertussis toxin bind to different domains on the same p73 receptor on murine splenocytes

1993 • 18 citations

Treatment with pentoxifylline and ciprofloxacin reduces the toxicity of high-dose interleukin-2 and lymphokine-activated killer cells.

1993 • 10 citations

Generation of phosphatidic acid and diacylglycerols following ligation of surface immunoglobulin in human B lymphocytes: Potential role in PKC activation

1992 • 7 citations