Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

1990 • 2,936 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein

1989 • 680 citations

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

1995 • 493 citations

Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease

1994 • 449 citations

Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

1994 • 420 citations

A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism

1995 • 337 citations

Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α₂‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein

1995 • 297 citations

Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease

1996 • 244 citations

Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease

1995 • 171 citations

Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population

1997 • 143 citations

Presenilin-1 polymorphism and Alzheimer's disease

1996 • 58 citations

Polymorphism in AACT gene may lower age of onset of Alzheimerʼs disease

1996 • 53 citations

Molecular genetics of Alzheimer's disease

1996 • 39 citations

Lack of association of trinucleotide repeat polymorphisms in the very‐low‐density lipoprotein receptor gene with Alzhelner's disease

1996 • 27 citations

Structure of the Gene (LRP1) Coding for the Human α2-Macroglobulin Receptor Lipoprotein Receptor-Related Protein

1994 • 27 citations

Tetranucleotide length polymorphism 5' of the 2-macroglobulin receptor (A2MR)/LDL receptor-related protein (LRP) gene

1994 • 26 citations

Short Report on DNA Marker at Candidate Locus

1996 • 8 citations