Complementary roles of mutations at positions 69 and 242 in a class A β-lactamase

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Proteins: Structures and Molecular Properties

1986 • 2,694 citations

Tertiary templates for proteins

1987 • 1,485 citations

Interior and surface of monomeric proteins

1987 • 924 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Prediction of Protein Structure and the Principles of Protein Conformation

1989 • 814 citations

More extended-spectrum beta-lactamases

1991 • 740 citations

Crystal structure of Escherichia coli TEM1 β‐lactamase at 1.8 Å resolution

1993 • 349 citations

The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 <scp>dd</scp>-peptidase family

1988 • 334 citations

Kinetic interactions of tazobactam with beta-lactamases from all major structural classes

1993 • 273 citations

Prediction of protein structure and principles of protein conformation

1990 • 267 citations

Proteins: Structures and Molecular Properties

1985 • 198 citations

β‐Lactamase of Bacillus licheniformis 749/C at 2 Å resolution

1990 • 175 citations

Clavulanic acid, a novel β-lactam isolated from Streptomyces clavuligerus; X-ray crystal structure analysis

1976 • 160 citations

Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli

1993 • 158 citations

Efficient Degradation of Trichloroethylene by a Recombinant Escherichia Coli

1989 • 157 citations

β-Lactamase of Bacillus licheniformis 749/C

1991 • 141 citations

Inactivation of class A .beta.-lactamases by clavulanic acid: the role of arginine-244 in a proposed nonconcerted sequence of events

1993 • 135 citations

Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors

1994 • 123 citations

Clinical isolates of Escherichia coli producing TRI β-lactamases: novel TEM-enzymes conferring resistance to β-lactamase inhibitors

1992 • 119 citations

Efficient site-directed in vitro mutagenesis using phagemid vectors.

1989 • 118 citations

Elucidation of the role of arginine-224 in the turnover processes of class A .beta.-lactamases

1992 • 116 citations

Penicillanic acid sulfone: an unexpected isotope effect in the interaction of 6.alpha.- and 6.beta.-monodeuterio and of 6,6-dideuterio derivatives with RTEM .beta.-lactamase from Escherichia coli. Crystal structure of penicillanic acid sulfone

1981 • 107 citations

Role of Ser-238 and Lys-240 in the hydrolysis of third-generation cephalosporins by SHV-type beta-lactamases probed by site-directed mutagenesis and three-dimensional modeling.

1993 • 106 citations

Site-directed mutagenesis at the active site of Escherichia coli TEM-1 beta-lactamase. Suicide inhibitor-resistant mutants reveal the role of arginine 244 and methionine 69 in catalysis.

1992 • 96 citations

β‐lactamase TEM1 of E. coli Crystal structure determination at 2.5 Å resolution

1992 • 72 citations

TRC-1: Emergence of a clavulanic acid-resistant TEM β-lactamase in a clinical strain

1992 • 58 citations

Site-saturation mutagenesis and three-dimensional modelling of ROB-1 define a substrate binding role of Ser 130 in class A β-lactamases

1992 • 47 citations

OHIO-1 β-lactamase resistant to mechanism-based inactivators

1992 • 37 citations

In vitro antibacterial activities of PD 131628, a new 1,8-naphthyridine anti-infective agent

1991 • 32 citations

OHIO-1 beta-lactamase is part of the SHV-1 family

1990 • 29 citations

Mutations altering substrate specificity in OHIO-1, and SHV-1 family β-lactamase

1992 • 14 citations

Crystal structure of 2 ‐ (2‐Amino‐4‐thiazolyl) 2 Z ‐ methoxyimino methylacetamide hydrochloride monohydrate an analog to the C₇ side chain of cefotaxime

1988 • 4 citations